Fluoroquinolones directly drive mitochondrial hyperpolarization and modulate iNOS expression in monocyte-derived macrophage populations [0.03%]
氟喹诺酮类药物可直接驱动单核细胞衍生的巨噬细胞群中的线粒体膜电位过度升高并调节iNOS表达
Alexander W Hardgrave,Megan Dooley,Ivy Maminimini et al.
Alexander W Hardgrave et al.
Introduction: The fluoroquinolone levofloxacin is often selected for use prophylactically as well as during respiratory infections. However, studies on how these antibiotics may alter innate immunity, as opposed to their ...
Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells [0.03%]
αβ T 细胞中关于CASPASE-8独立于RIPK1的存活机制的确证
Farjana Islam,Scott Layzell,Ines Boal-Carvalho et al.
Farjana Islam et al.
Introduction: CASPASE8 promotes both cell death and survival by acting as a trigger of apoptosis and a repressor of necroptosis. In T cells, the function and mechanisms of CASPASE8 are incompletely understood. ...
Cytokine-induced transcriptional changes in human neutrophils reveal immune regulatory plasticity [0.03%]
细胞因子诱导的人中性粒细胞转录变化揭示免疫调节可塑性
Huw B Thomas,Steven W Edwards,Helen L Wright
Huw B Thomas
Introduction: Neutrophils are innate immune cells that play a central role in the inflammatory response. They produce an array of destructive molecules and anti-microbial proteases that characterize the cells as front-lin...
Vaccination of calves with Bacille Calmette Guerin increased the frequency but did not affect aggregation or clustering of natural killer cells in draining lymph nodes [0.03%]
卡介苗免疫小牛增加自然杀伤细胞频率但不会影响引流淋巴结中自然杀伤细胞的聚集或聚类现象
Jayne C Hope,Sarah Ho,Clara Zifko et al.
Jayne C Hope et al.
Introduction: Natural killer (NK) cells are central to innate immune responses but they also influence adaptive immunity. Evidence suggests that NK cells are involved in protective immune responses induced by the Bacille ...
PROS1 released by lung basal cells limits inflammation in epithelial and monocytes during SARS-CoV-2 infection [0.03%]
肺泡基底细胞释放的PROS1在SARS-CoV-2感染中限制上皮细胞和单核细胞炎症反应
Theodoros Simakou,Agnieszka M Szemiel,Lucy MacDonald et al.
Theodoros Simakou et al.
Introduction: Factors regulating the severity of pneumonitis during viral infections remain unresolved. We previously found higher expression of protein S (PROS1) in lung epithelium of mild compared to severe coronavirus ...
Differentially expressed growth factors and cytokines drive phenotypic changes in transmissible cancers [0.03%]
差异表达的生长因子和细胞因子驱动传染性肿瘤的表型变化
Kathryn G Maskell,Anna Schönbichler,Andrew S Flies et al.
Kathryn G Maskell et al.
Introduction: The Tasmanian devil is threatened by two deadly transmissible Schwann cell cancers. A vaccine to protect Tasmanian devils from both devil facial tumour 1 (DFT1) and devil facial tumour 2 (DFT2), and improved...
Inflammation's impact on the interaction between oligodendrocytes and axons [0.03%]
炎症对少突胶质细胞和轴突相互作用的影响
Tabitha R F Green,Marieke Pingen,Julia M Edgar
Tabitha R F Green
Oligodendrocytes are responsible for the myelination of axons and providing trophic and metabolic support to the myelinated axon. They also interact with immune effector cells, including microglia and T cells, hence, are involved in central...
Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation [0.03%]
spermidine通过eIF5A的hypusination和代谢适应抑制DC活化
Gavin R Meehan,Utku Gunes,Larissa Camargo da Rosa et al.
Gavin R Meehan et al.
Introduction: Cell metabolism plays an important role in immune effector responses and through responding to metabolic signals, immune cells can adapt and regulate their function. Arginine metabolism in dendritic cells (D...
CD28 and TCR differentially impact naïve and memory T cell responses [0.03%]
共刺激分子和T细胞受体对 naive及memory T细胞活化的影响不同
Cayman Williams,Dalisay Giovacchini,Alan Kennedy et al.
Cayman Williams et al.
Manipulating CD28 co-stimulation is a key element of anti-tumour immune responses and treating autoimmune diseases. CD28 can reduce the T cell activation threshold but has a complex relationship with T cell receptor (TCR) signalling and an ...
Correction to: Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis [0.03%]
Correction：PD-1敲除小鼠肝内粒细胞肉芽肿型炎症反应由从头基因组突变诱发
[This corrects the article DOI: 10.1093/discim/kyae018.]. © The Author(s) 2025. Published by Oxford University Press on behalf of the British Society fo...
Published Erratum
Discovery immunology. 2025 Jun 5;4(1):kyaf010. DOI:10.1093/discim/kyaf010 2025