Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, Hp-TGM [0.03%]
利用线虫来源的转化生长因子-β免疫调节模拟物Hp-TGM防治T细胞依赖性结肠炎
Danielle J Smyth,Madeleine P J White,Chris J C Johnston et al.
Danielle J Smyth et al.
In animal models of inflammatory colitis, pathology can be ameliorated by several intestinal helminth parasites, including the mouse nematode Heligmosomoides polygyrus. To identify parasite products that may exert anti-inflammatory effects ...
Thomas A E Elliot,Emma K Jennings,David A J Lecky et al.
Thomas A E Elliot et al.
In lymphocytes, Nr4a gene expression is specifically regulated by antigen receptor signalling, making them ideal targets for use as distal T cell receptor (TCR) reporters. Nr4a3-Timer of cell kinetics and activity (Tocky) mice are a ground-...
NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression [0.03%]
NKG2D信号通过调控小鼠中的IL-17A产生型γδT细胞来促进肿瘤进展
Sophie Curio,Sarah C Edwards,Toshiyasu Suzuki et al.
Sophie Curio et al.
γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance, homeostasis, and cancer. γδT cells recognize stressed cells or cancer cells through the NKG2D receptor to ...