Impact of SIRPα genotype combinations in recipients and donors on alloimmune response in liver transplantation [0.03%]
受者和供者的SIRPα基因型组合对肝脏移植后allo免疫反应的影响
Akhmet Seidakhmetov,Naoki Tanimine,Yuka Tanaka et al.
Akhmet Seidakhmetov et al.
The signal regulatory protein alpha (SIRPα)-CD47 axis regulates self-tolerance by delivering inhibitory signals to phagocytic cells and influencing immune responses in transplantation. This study examined the impact of SIRPα polymorphisms...
Raphael Fortulan,Noushin Raeisi Kheirabadi,Alessandro Chiolerio et al.
Raphael Fortulan et al.
In this work, we introduce encapsulated wine beads as a novel, edible material for unconventional and neuromorphic computing. When encapsulated in alginate beads, wine, a complex mixture of proteins, organic acids, sugars, metal ions, and v...
Single-fibril Förster resonance energy transfer imaging and deep learning reveal concentration dependence of amyloid β 42 aggregation pathways [0.03%]
单 fibril 荧光能量共振转移成像和深度学习揭示了淀粉样蛋白 β 42 纤丝聚合途径的浓度依赖性规律
Sara H Sohail,Janghyun Yoo,Hoi Sung Chung
Sara H Sohail
Amyloid fibril formation is a highly heterogeneous process as evidenced by polymorphism in fibril structure. It has been suggested that different polymorphs are associated with different diseases or disease subtypes. Detailed characterizati...
Arnald Puy,Seth N Linga,Nanxin Wei et al.
Arnald Puy et al.
A prevailing notion in sustainability science is that irrigated agriculture underpins global food and water security because it accounts for 40% of crop production and 70% of freshwater withdrawals. Through a network citation analysis of 3,...
Tiled material systems: Exploring biodiversity and multifunctionality of a universal and structural motif [0.03%]
平铺材料系统：探索一种通用和结构母题的生物多样性和多功能性
Jana Ciecierska-Holmes,Nikolai Rosenthal,Jan Wölfer et al.
Jana Ciecierska-Holmes et al.
Humans are drawn to patterns and hierarchies in nature, mimicking them particularly in decoration and architecture. Natural patterns, however, are never purely esthetic and, since evolution works on a variety of factors simultaneously, natu...
PNAS Nexus: Multidisciplinary convergence in the pursuit of useful purposes [0.03%]
PNAS Nexus：以求同为目的的多学科汇聚
Yannis C Yortsos
Yannis C Yortsos
HIV-1-specific CD8+ T cells with different abilities to recognize HIV-1-infected cells in HIV-1-exposed seronegative individuals [0.03%]
识别人类免疫缺陷病毒(HIV)感染细胞能力不同的HIV特异性CD8+T细胞对 HIV阴性的HIV感染者的影响
Hung The Nguyen,Takayuki Chikata,Nozomi Kuse et al.
Hung The Nguyen et al.
The presence of HIV-1-specific CD8+ T-cell responses in HIV-1-exposed seronegative (HESN) individuals has been reported, but the details of these T cells have yet to be analyzed. We investigated HIV-1-specific CD8+ T-cell responses to 281 1...
Increase of Inhibitory Siglec receptors on T cells mitigates severe immune reactions during acute viral infections [0.03%]
急性病毒感染期间T细胞上抑制性Siglec受体的增加可缓解严重免疫反应
Natalia Rodrigues Mantuano,Anne Bärenwaldt,Mirza Sarcevic et al.
Natalia Rodrigues Mantuano et al.
Expression of inhibitory Siglec receptors has been described on T cells of patients with viral infection and cancer. However, the exact function and their role in T-cell activation and control of infections have not been well investigated. ...
The local inactivation of glucocorticoid as regulator for the development of glucocorticoid-induced osteoporosis [0.03%]
糖皮质激素局部失活作为糖皮质激素诱导的骨质疏松症发展的调节因子
Martina Blaschke,Ina Dressel,Regine Köpp et al.
Martina Blaschke et al.
Exogenous glucocorticoids (GCs) like prednisone are used to treat inflammatory diseases in nearly 10% of older patients. This increases osteoporosis and the risk of fractures. Until now, the negative effect on bone is thought to be a direct...
Conservation of glial density and cell-type ratios within a brain region across mammals [0.03%]
哺乳动物大脑区域中胶质细胞密度及各类细胞比值的守恒性
Antonio Pinto-Duarte,Katharine Bogue,Terrence J Sejnowski et al.
Antonio Pinto-Duarte et al.
Glial cells in the brain are as numerous as neurons, but their organization is less understood. One view suggests that glial organization is similar across brain regions. To better understand glial organization, we examined functionally and...