Investigation and computational prediction of gating pore currents in NaV1.2 mutations across clinical phenotypes [0.03%]
针对临床表型的NaV1.2突变的闸孔电流的调查和计算预测
Ahmed Eltokhi,Eslam Elhanafy,Jing Li et al.
Ahmed Eltokhi et al.
Voltage sensor domains (VSDs) are integral and common regions within voltage-gated ion channels that play a crucial role in cellular signaling and excitability. Each VSD comprises four transmembrane segments (S1-S4) per domain. The transmem...
Sequence-encoded conformational biases correlate with self-assembly modes of intrinsically disordered proteins [0.03%]
序列编码的构象偏向与内在无序蛋白的自组装模式相关
Ryoga Kobayashi,Norio Yoshida,Yohei Miyanoiri et al.
Ryoga Kobayashi et al.
Self-assembly of intrinsically disordered proteins (IDPs) underlies cellular functions and disease pathogenesis. This process is mediated by two intermolecular interaction modes: point-to-point contacts described by the sticker-and-spacer f...
David S Jin,Oumayma Agdali,Taruna Yadav et al.
David S Jin et al.
Awareness of action (AoA), or conscious awareness of an action just performed, is an important part of daily experience with major practical and ethical relevance, yet the neural mechanisms of AoA remain largely unknown. The main barrier to...
Jean-Baptiste Camps,Julien Randon-Furling,Ulysse Godreau
Jean-Baptiste Camps
Knowledge of past cultures relies heavily on surviving written material. Over the centuries, texts were copied, altered, and often lost, leaving scholars to reconstruct partial genealogies-stemmata-from shared innovations between surviving ...
Effects of genotypic diversity on growth and survival of an ecologically important coral [0.03%]
基因型多样性对一种生态重要珊瑚的生长和存活的影响
Cody S Clements,Zoe A Pratte,Frank J Stewart et al.
Cody S Clements et al.
Biodiversity loss threatens ecosystems worldwide, but we lack a thorough understanding of how genotypic diversity-as opposed to species diversity-impacts threatened foundation species, such as corals on tropical reefs. Corals of the genus P...
An expanding human footprint drives escalating human-elephant conflict across a transboundary African landscape through 2085 [0.03%]
不断扩张的人类活动足迹加剧了跨境非洲景观中的人象冲突（至2085年）
Evan Patrick,Maxwell Pepperdine,Christy Yu et al.
Evan Patrick et al.
Rapid land-use change is compressing the space between people and wildlife at an unprecedented pace, elevating concerns of conflict between people and keystone megafauna such as the African savanna elephant (Loxodonta africana). However, th...
A train-and-assist device that upskills novices to strengthen the workforce and expand diagnostic access [0.03%]
一种培训设备可使新手快速上手提升劳动力队伍水平并扩大诊疗范围
Minkyo Lee,Xinyue Penny Pei,Si Hyung Jin et al.
Minkyo Lee et al.
AI and automation technologies are displacing millions of workers across industries in developed countries, while many developing nations continue to grapple with chronically high unemployment. Meanwhile, healthcare laboratories-particularl...
Nematomorph parasites potentially drive nutritional flow from terrestrial to aquatic ecosystems [0.03%]
毛纤毛虫可能潜在地推动了陆地到水域生态系统的营养流动
Ayano Medo,Takuya Sato
Ayano Medo
Long-chain polyunsaturated fatty acids (LC-PUFA), particularly eicosapentaenoic acid (EPA; 20:5n-3) are synthesized primarily by algae, such as diatoms and cryptophytes, in aquatic ecosystems. Although LC-PUFA flux has commonly been conside...
Moral perspective-taking can reduce polarization around climate policy in the United States [0.03%]
道德视角的转变可以减少美国气候政策上的分歧
Kristin F Hurst,Zachary M Hurst
Kristin F Hurst
Polarization is a barrier to the large-scale collective action urgently needed to address the climate crisis. Moral perspective-taking (MPT) combines counter-attitudinal argument generation with moral framing as a strategy for reducing pola...
Sylvia C L Durian,Kyle Bojanek,Olivier Marre et al.
Sylvia C L Durian et al.
Retinal ganglion cells show high convergence onto their downstream projections, which poses a problem for information transfer: how can information be preserved through a synaptic layer that has significantly more inputs than outputs? Lossy...