Transient YAP activation uncovers the neurogenic potential of proliferative mammalian Müller glia [0.03%]
瞬时YAP激活揭示了增殖性哺乳动物Müller胶质细胞的神经发生潜能
English J Laserna,Irina V Saltykova,Benjamin M Hall et al.
English J Laserna et al.
The Hippo pathway effector YAP promotes spontaneous proliferation of Müller glia (MG), suggesting that bypassing Hippo signaling and activating YAP could enhance retinal regeneration. However, whether proliferative adult MGs retain meaning...
Physics-informed differentiable solvers for learning parametric solution manifolds in heterogeneous physical systems [0.03%]
基于物理的可微求解器在异构物理系统中学习参数解流形
Milad Panahi,Giovanni Michele Porta,Monica Riva et al.
Milad Panahi et al.
Quantifying parametric uncertainty in partial differential equations is a central challenge to our ability to model the behavior of heterogeneous systems. This challenge is relevant to a variety of fundamental and application-oriented impli...
Tom Bertalan,George A Kevrekidis,Eleni D Koronaki et al.
Tom Bertalan et al.
Classically, to solve differential equation problems, it is necessary to specify sufficient initial condition and/or boundary condition (BC) so as to allow the existence of a unique solution. Well-posedness of differential equation problems...
Vincent Hakim,Alain Karma
Vincent Hakim
Echo state networks are well-known for their ability to learn temporal patterns through simple feedback to a large recurrent network with random connections. However, the learning process itself remains poorly understood. We develop a quant...
Methicillin treatment reveals that FtsZ phosphorylation influences the cell division of Streptococcus pneumoniae [0.03%]
甲氧西林治疗发现FtsZ磷酸化影响肺炎链球菌的细胞分裂
Sathya Narayanan Nagarajan,Sylvie Manuse,Dimitri Juillot et al.
Sathya Narayanan Nagarajan et al.
Protein phosphorylation plays a crucial role in regulating cell division and morphogenesis in many bacteria. In Streptococcus pneumoniae, the serine/threonine kinase StkP orchestrates cell wall assembly and cell morphogenesis by phosphoryla...
Unified climate factors predict influenza outbreak seasonality across tropical and temperate regions [0.03%]
统一的气候因素可以预测跨越热带和温带地区的流感季节性爆发
Aleksandra R Stamper,Wenchang Yang,Caroline E Wagner et al.
Aleksandra R Stamper et al.
Influenza represents a source of considerable morbidity and mortality worldwide, exhibiting seasonal outbreak patterns that vary by location. Temperate regions typically experience sharp wintertime peaks, while tropical regions tend to exhi...
Functional anisotropy of the elephant trunk skin: A biological blueprint for grasping, protection, and tactile sensing [0.03%]
大象颈部皮肤的功能各向异性：抓握、保护和触觉感知的生物蓝图
Matteo Lo Preti,Paule Dagenais,Behnam Kamare et al.
Matteo Lo Preti et al.
Muscular hydrostats, like the elephant trunk, face a fundamental biomechanical conflict between robust protection and delicate manipulation. How the skin, a critical structural and sensory component, resolves this paradox is largely unknown...
A J Venkatakrishnan,Karthik Murugadoss,Venky Soundararajan
A J Venkatakrishnan
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for obesity and type 2 diabetes, yet substantial variability in weight-loss response remains poorly understood. We conducted a retrospective cohort study using de-identifi...
Robustness is important: Limitations of LLMs for predictions on tabular data [0.03%]
稳健性很重要：LLM在表格数据预测中的局限性
Hejia Liu,Mochen Yang,Gediminas Adomavicius
Hejia Liu
Large language models (LLMs) are being applied in a wide array of settings, well beyond typical language-oriented use cases. In particular, LLMs are increasingly used as a plug-and-play method for generating predictions on tabular data. Pri...
Francesca Mignacco,Francesco Mori
Francesca Mignacco
Learning is a complex dynamical process shaped by a range of interconnected decisions. Careful design of hyperparameter schedules for artificial neural networks or efficient allocation of cognitive resources by biological learners can drama...