Structural insights into endogenous agonist selectivity of aminergic receptors from the octopamine β2 receptor [0.03%]
来自八胺β2受体的肾上腺素能受体内源性激动剂选择性的结构见解
Tetsuya Hori,Kazushige Katsura,Sayako Miyamoto-Kohno et al.
Tetsuya Hori et al.
Tyrosine-derived amines (TDAs), such as octopamine, noradrenaline, dopamine, and tyramine, are essential neurotransmitters that play diverse roles in various physiological processes. The distinct receptor selectivity of these structurally s...
Visual quorum sensing in chiral suspensions: Hyperuniformity and edge currents [0.03%]
手性悬浮液中的视觉表决感应： 超均匀性和边缘电流
Yuxin Zhou,Qingqing Yin,Shubhadip Nayak et al.
Yuxin Zhou et al.
A well-established phenomenon in active matter is motility-induced phase separation. However, biological systems exhibit a much broader range of collective behaviors and functions due to the exchange of information among their components. I...
Sequence-encoded tubular architectures in disordered spider silk proteins revealed by multiscale simulations and NMR [0.03%]
多尺度模拟和NMR揭示无序的蜘蛛丝蛋白中的序列编码管状结构
Christopher J Forman,David Onofrei,Dillan Stengel et al.
Christopher J Forman et al.
Spider silk proteins (spidroins) are large, block-copolymer-like proteins that must remain soluble at high concentration in the spinning dope while being primed for rapid fiber formation. Understanding how these intrinsically disordered pro...
Charles Sims,Gasser G Ali,J Scott Holladay et al.
Charles Sims et al.
The adoption of rooftop photovoltaic (PV) systems can create upward pressure on retail electricity rates as utilities are forced to spread their fixed costs of generation and transmission across a smaller customer base. Since high-income ho...
Unsupervised detection of building destruction during war from publicly available radar satellite imagery [0.03%]
基于开源雷达卫星图像的无监督建筑战争损毁监测方法研究
Daniel Racek,Qi Zhang,Paul Wilhelm Thurner et al.
Daniel Racek et al.
Automated detection of building destruction in conflict zones is crucial for human rights monitoring, humanitarian response, and academic research. However, existing approaches (i) rely on proprietary satellite imagery, both expensive and o...
Reversible formation of von-Willebrand-factor-platelet aggregates in microvascular blood flow [0.03%]
微血管血液流中vWF-血小板聚集体的可逆形成
Alper Topuz,Masoud Hoore,Gerhard Gompper et al.
Alper Topuz et al.
Von Willebrand factor (VWF) and blood platelets play a key role in blood clotting by forming VWF-platelet aggregates. Using mesoscale hydrodynamic simulations, we study the behavior of these aggregates in microvascular blood flow. In microv...
Beyond the click: Pixel tracking technologies and patient data security in hospitals [0.03%]
点击之外：像素追踪技术与医院患者数据安全
Hilal Atasoy,Ryan McDonough,Guangyue Maria Zhang
Hilal Atasoy
Digital tracking technologies have transformed and enhanced online data collection across industries. Their integration into healthcare systems, however, raises urgent concerns about patient privacy and security. This study provides the fir...
Correction to: Understanding reaction to corporate activism: The moderating role of polarization [0.03%]
Correction to: 认识企业积极行为的作用：极化作用的调节因素
[This corrects the article DOI: 10.1093/pnasnexus/pgae313.]. © The Author(s) 2025. Published by Oxford University Press on behalf of National Academy of...
Published Erratum
PNAS nexus. 2025 Dec 9;4(12):pgaf380. DOI:10.1093/pnasnexus/pgaf380 2025
Challenges in understanding and communicating the risk of zoonotic disease spillover from wild animal meat [0.03%]
了解和传达野生动物肉类导致人畜共患病传播的风险的挑战
Natalie Yoh,Gebbiena M Bron,Amy Ickowitz et al.
Natalie Yoh et al.
Discussions around managing hunting and the consumption of wild animal meat increasingly emphasizes public health concerns and the risk of zoonotic spillover. In this article, we explore factors that may lead to under- or overestimating hea...
Hugh Sparks,Leo Rowe-Brown,Yuriy Alexandrov et al.
Hugh Sparks et al.
Oblique plane microscopy (OPM) is a form of light-sheet fluorescence microscopy (LSFM) employing a single microscope objective at the sample for both fluorescence excitation and detection. Dual-view OPM (dOPM) is an optically folded form of...