Naoki Masuda
Naoki Masuda
Anticipating tipping points in complex systems is a fundamental challenge across domains. Traditional early warning signals (EWSs) based on critical slowing down, such as increasing sample variance, are widely used, but their ability to rel...
Animal-origin-free culture improves mitotic response for chromosome aberration analysis of human peripheral blood [0.03%]
无动物来源培养基提高人外周血染色体畸变分析的有丝分裂效应
Yohei Fujishima,Donovan Anderson,Shara Kamakura et al.
Yohei Fujishima et al.
The lymphocyte culture method for chromosomal aberration analysis was established in the 1960s, and culture media supplemented with fetal bovine serum (FBS) have been routinely used. However, issues such as lot-to-lot variability, potential...
Molecular basis for alternative charge separation pathways in type-II photosynthetic reaction centers [0.03%]
II型光合反应中心中替代电荷分离途径的分子机制
Tomoyasu Noji,Keisuke Saito,Hiroyuki Tamura et al.
Tomoyasu Noji et al.
In photosynthetic reaction centers from purple bacteria, bacteriochlorophyll a (the special pair PAPB and accessory bacteriochlorophyll BA) and bacteriopheophytin a (HA) form the active electron-transfer branch and uniquely contain a polar ...
Correction to: Spatiotemporal predictions of toxic urban plumes using deep learning [0.03%]
关于使用深度学习预测有毒城市烟羽的时空变化的更正通知
[This corrects the article DOI: 10.1093/pnasnexus/pgaf198.]. © The Author(s) 2026. Published by Oxford University Press on behalf of National Academy of...
Published Erratum
PNAS nexus. 2026 Apr 24;5(4):pgag064. DOI:10.1093/pnasnexus/pgag064 2026
Orbiting, colliding, and merging liquid lenses on a soap film: Toward gravitational analogs [0.03%]
轨道碰撞和合并的液态透镜：肥皂膜中的类比模型与引力表征
Jean-Paul Martischang,Benjamin Reichert,Ilies Haouche et al.
Jean-Paul Martischang et al.
Gravity governs the large-scale structure of the Universe, driving the formation and interactions of galaxies. These interactions generate distinctive features-such as complex orbits, tidal spiral arms, and bridges-that are commonplace at a...
Astrocytic frataxin deficiency drives neurocognitive impairment in sickle cell mice [0.03%]
缺铁小鼠星形胶质细胞中frataxin缺乏导致神经认知障碍
Enrico M Novelli,Shane C Lenhart,Lesley M Foley et al.
Enrico M Novelli et al.
Individuals with sickle cell disease (SCD) suffer from a high burden of neurocognitive impairment. Cerebrovascular lesions, characterized by diffusion tensor imaging identified neuroaxonal damage, are associated with learning and memory def...
Discovery tools: How powerful new scientific methods and instruments emerge and catalyze innovation [0.03%]
发现工具：强大的新科研手段和仪器是如何涌现并催化创新的
Alexander Krauss
Alexander Krauss
Powerful new methods and tools drive scientific progress-but how do we actually make such innovations? No theory yet explains how we invent major tools across fields. To address this gap, we examine all nobel-prize-winning method discoverie...
Abhishek Yadav,Francesco Caravelli,David Wolpert
Abhishek Yadav
Mismatch cost (MMC) is a universally applicable lower bound on the entropy production (EP) of any fixed physical process across a given time interval. In the first part of the article, we establish results concerning MMC to prove that it sc...
Reversible and causal epigenetic information loss in liver aging and disease [0.03%]
可逆且因果的表观遗传信息在肝脏衰老和疾病中的丧失
Roni B Shtark,Naor Sagy,Noga Korenfeld et al.
Roni B Shtark et al.
The loss of epigenetic information has been proposed as a driver of aging and diseases, but the reversibility and causality of this process remain underexplored. Here, we analyze liver-unique methylation sites-genomic loci that show distinc...
Yangshin Park,Chunxiang Wu,Kayla Tennessen et al.
Yangshin Park et al.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease, yet the molecular mechanism governing LRRK2 activation remains incompletely understood. LRRK2 is a large multidomain enzyme whose k...