Functional MRI detection of blood-oxygenation-level-dependent responses in both white and gray matter of the spinal cord after optogenetic cortical stimulation [0.03%]
光学皮层刺激后脊髓灰质和白质血氧水平依赖性功能磁共振成像检测
John C Gore,Pai-Feng Yang,Arabinda Mishra et al.
John C Gore et al.
We report the first demonstrations of neural activity detected using functional MRI within both the gray and white matters of the cervical spinal cord of nonhuman primates in response to stimulation by optogenetic excitation of brain cortex...
Triangle weaver spiders construct spring-loaded webs using a novel set of genes for exceptionally proline-rich silk [0.03%]
利用新型脯氨酸丰富蚕丝基因构建弹力网的三角园蛛
Steven Casey,Sandra M Correa-Garhwal,Richard H Baker et al.
Steven Casey et al.
Spiders amplify their physical capabilities by synthesizing multiple high performing silks. Renowned for its toughness, major ampullate (MA) silk composes the spiderweb frame, providing support and absorbing high-energy impacts. In ecribell...
Brain activity explains message effectiveness: A mega-analysis of 16 neuroimaging studies [0.03%]
大脑活动解释了信息的有效性：来自16个神经影像研究的大型分析结果
Christin Scholz,Hang-Yee Chan,Jeesung Ahn et al.
Christin Scholz et al.
Persuasive communication in marketing, political, and health domains influences sales, elections, and public health. We present a mega-analysis (a pooled analysis of raw data) of 16 functional MRI datasets (572 participants, 739 messages, a...
Dynamic claw of dengue protease unveils druggability potential with high affinity allosteric inhibitors [0.03%]
登革热蛋白酶动态钳形结构域利用高亲和力别构抑制剂揭示可成药性潜力
Mrinmay Bhunia,Rajdip Misra,Anupam Maity et al.
Mrinmay Bhunia et al.
Several enzymes receive functional signals from allosteric site to the active site through conformational dynamics while domain dynamics can also play a significant role. Current investigation identifies a claw-like regulatory region near t...
Gary Tom,Edwin Yu,Naruki Yoshikawa et al.
Gary Tom et al.
This study investigates the impact of incorporating stereochemical information, a crucial aspect of computational drug discovery and materials design, in molecular generative modeling. We present a detailed comparison of stereochemistry-awa...
The heterogeneous impact of public security cameras on safety perceptions in cities: Evidence from China [0.03%]
中国城市公共安全摄像头对安全感影响的异质性证据
Pinghan Liang,Yadi Liu,Yuchen Guo et al.
Pinghan Liang et al.
Digital public security systems in cities, such as surveillance cameras, can record illegal behavior and deter crime, thereby enhancing residents' perceptions of safety. However, the impact of public surveillance cameras on residents' safet...
Estimating the effect size of moral contagion in online networks: A pre-registered replication and meta-analysis [0.03%]
一种预注册重复检验和元分析估算在线社交网络中的道德感染效应大小
William J Brady,Steve Rathje,Laura K Globig et al.
William J Brady et al.
Over 5 billion people now use social media platforms. As our social lives become increasingly entangled with online social networks, it is important to understand the dynamics of online information diffusion. This is particularly true for t...
Activation of orexin neurons changes reward-based decision-making strategies [0.03%]
催醒肽神经元的激活可改变基于奖励的选择策略
Hiroyuki Mizoguchi,Kentaro Katahira,Ayumu Inutsuka et al.
Hiroyuki Mizoguchi et al.
Orexin neurons regulate physiological functions, including not only energy homeostasis and wakefulness but also motivated behaviors. These neurons play important roles in linking metabolic requirements to such behaviors. However, it is unkn...
Dialogues with large language models reduce conspiracy beliefs even when the AI is perceived as human [0.03%]
与大型语言模型对话可以减少阴谋论信念，即使AI被视为人类也是如此
Esther Boissin,Thomas H Costello,Daniel Spinoza-Martín et al.
Esther Boissin et al.
Although conspiracy beliefs are often viewed as resistant to correction, recent evidence shows that personalized, fact-based dialogues with a large language model (LLM) can reduce them. Is this effect driven by the debunking facts and evide...
Tissue tension of planar, free standing cell monolayers measured by central deformation [0.03%]
利用中心变形测量二维单层细胞张力
Amaury Perez-Tirado,Ulla Unkelbach,Andreas Janshoff
Amaury Perez-Tirado
Polar epithelial cells form thin but resilient sheets that resist mechanical in-plane stress by relying on strong conformal contacts mediated by dedicated cell-cell connections linked to the viscoelastic cortex. In this study, we investigat...