A genome-wide RNAi screen for novel CIN genes using human artificial chromosome [0.03%]
基于人工染色体的全基因组RNAi筛选癌症合子基因
Mikhail Liskovykh,Natalia Y Kochanova,Chih-Yuan Chiang et al.
Mikhail Liskovykh et al.
Chromosome instability (CIN) remains among the most important problems in modern cancer research. In this study, we conducted a genome-wide RNAi screen to identify genes that contribute to CIN. To achieve this, we used a human artificial ch...
Correction to: AI-based satellite survey offers independent assessment of migratory wildebeest numbers in the Serengeti [0.03%]
谨防人工智能驱动的卫星调查在独立估算塞伦盖蒂迁徙角马数量中的误差
[This corrects the article DOI: 10.1093/pnasnexus/pgaf264.]. © The Author(s) 2025. Published by Oxford University Press on behalf of National Academy of...
Published Erratum
PNAS nexus. 2025 Dec 17;4(12):pgaf382. DOI:10.1093/pnasnexus/pgaf382 2025
Mutation-specific roles of sustained sodium current (INa) in guiding precision medicine for long QT syndrome type 3 [0.03%]
长QT间期综合征3型中持续性钠电流在突变特异性精准医疗中的指导作用
Vichaya Auvichayapat,Sarin Lekchuensakul,Pharawee Wandee et al.
Vichaya Auvichayapat et al.
Long QT syndrome type 3 (LQTS3), caused by gain-of-function mutations in the SCN5A gene, encompasses a spectrum of clinical presentations, ranging from asymptomatic carriers to severe arrhythmic phenotypes, representing the "silent killer" ...
Simon Grosse-Holz,Leonid A Mirny,Antoine Coulon
Simon Grosse-Holz
The nucleus of a cell contains its genetic information in the form of chromatin: polymers of DNA and associated proteins. The physical nature of this polymer system is yet to be understood. Orthogonal experimental approaches probing chromos...
Self-organization of common good usage and an application to Internet services [0.03%]
公共资源使用的自发组织及在互联网服务业中的应用研究
Diogo L Pires,Vincenzo Mancuso,Paolo Castagno et al.
Diogo L Pires et al.
Natural and human-made common goods present key challenges due to their susceptibility to degradation, overuse, and congestion. We explore the self-organization of their usage when individuals have access to several available commons but li...
Flexoelectricity and the fluctuations of (active) living cells: Implications for energy harvesting, ion transport, and neuronal activity [0.03%]
压电效应与(活性)生命细胞的涨落：能量采集、离子运输和神经元活动的启示
Pratik Khandagale,Liping Liu,Pradeep Sharma
Pratik Khandagale
Biological membranes universally exhibit flexoelectricity, a form of electromechanical coupling in which membrane curvature induces electric polarization. This phenomenon enables the conversion of mechanical deformations into electrical sig...
Americans overestimate how many social media users post harmful content [0.03%]
美国人高估了发布有害内容的社交媒体用户的比例
Angela Y Lee,Eric Neumann,Jamil Zaki et al.
Angela Y Lee et al.
Americans can become more cynical about the state of society when they see harmful behavior online. Three studies of the American public (n = 1,090) revealed that they consistently and substantially overestimated how many social media users...
Structural insights into endogenous agonist selectivity of aminergic receptors from the octopamine β2 receptor [0.03%]
来自八胺β2受体的肾上腺素能受体内源性激动剂选择性的结构见解
Tetsuya Hori,Kazushige Katsura,Sayako Miyamoto-Kohno et al.
Tetsuya Hori et al.
Tyrosine-derived amines (TDAs), such as octopamine, noradrenaline, dopamine, and tyramine, are essential neurotransmitters that play diverse roles in various physiological processes. The distinct receptor selectivity of these structurally s...
Visual quorum sensing in chiral suspensions: Hyperuniformity and edge currents [0.03%]
手性悬浮液中的视觉表决感应： 超均匀性和边缘电流
Yuxin Zhou,Qingqing Yin,Shubhadip Nayak et al.
Yuxin Zhou et al.
A well-established phenomenon in active matter is motility-induced phase separation. However, biological systems exhibit a much broader range of collective behaviors and functions due to the exchange of information among their components. I...
Sequence-encoded tubular architectures in disordered spider silk proteins revealed by multiscale simulations and NMR [0.03%]
多尺度模拟和NMR揭示无序的蜘蛛丝蛋白中的序列编码管状结构
Christopher J Forman,David Onofrei,Dillan Stengel et al.
Christopher J Forman et al.
Spider silk proteins (spidroins) are large, block-copolymer-like proteins that must remain soluble at high concentration in the spinning dope while being primed for rapid fiber formation. Understanding how these intrinsically disordered pro...