Kenji Fujita,Nashwa Masnoon,John Mach et al.
Kenji Fujita et al.
Precision medicine is an approach to maximise the effectiveness of disease treatment and prevention and minimise harm from medications by considering relevant demographic, clinical, genomic and environmental factors in making treatment deci...
Abdelbaset Elzagallaai,Charlotte Barker,Tamorah Lewis et al.
Abdelbaset Elzagallaai et al.
Precision Medicine is an approach to disease treatment and prevention taking into account individual genetic, environmental, therapeutic and lifestyle variability for each person. This holistic approach to therapeutics is intended to enhanc...
Building a precision medicine infrastructure at a national level: The Swedish experience [0.03%]
国家级精准医学基础设施建设：瑞典的经验
Anders Edsjö,Anna Lindstrand,David Gisselsson et al.
Anders Edsjö et al.
Precision medicine has the potential to transform healthcare by moving from one-size-fits-all to personalised treatment and care. This transition has been greatly facilitated through new high-throughput sequencing technologies that can prov...
Editorial on polygenic risk scores: Colloquium held at the Centre for Personalised Medicine, Oxford [0.03%]
关于多基因风险评分的观点：在牛津个性化医学中心举行的座谈会
Padraig Dixon,Sarah Briggs,Anneke Lucassen
Padraig Dixon
Bartłomiej Tomasik,Filip Garbicz,Marcin Braun et al.
Bartłomiej Tomasik et al.
Precision oncology is a rapidly evolving concept that holds great promise in cancer treatment. However, a cancer complexity attributed to genomic and acquired tumour heterogeneity limits treatment effectiveness and increases toxicity. These...
The ethical challenges of diversifying genomic data: A qualitative evidence synthesis [0.03%]
扩展基因组数据的伦理挑战：定性证据合成
Faranak Hardcastle,Kate Lyle,Rachel Horton et al.
Faranak Hardcastle et al.
This article aims to explore the ethical issues arising from attempts to diversify genomic data and include individuals from underserved groups in studies exploring the relationship between genomics and health. We employed a qualitative syn...
Cross-population applications of genomics to understand the risk of multifactorial traits involving inflammation and immunity [0.03%]
跨人群应用基因组学理解涉及炎症和免疫的多因素性状风险
Bana Alamad,Kate Elliott,Julian C Knight
Bana Alamad
The interplay between genetic and environmental factors plays a significant role in interindividual variation in immune and inflammatory responses. The availability of high-throughput low-cost genotyping and next-generation sequencing has r...
Delaney A Smith,Marie C Sadler,Russ B Altman
Delaney A Smith
Pharmacogenetics, the study of how interindividual genetic differences affect drug response, does not explain all observed heritable variance in drug response. Epigenetic mechanisms, such as DNA methylation, and histone acetylation may acco...
N J Schork,B Beaulieu-Jones,W S Liang et al.
N J Schork et al.
Studies on humans that exploit contemporary data-intensive, high-throughput 'omic' assay technologies, such as genomics, transcriptomics, proteomics and metabolomics, have unequivocally revealed that humans differ greatly at the molecular l...