Precision oncology: Computational methods for multi-omics data integration to improve drug response prediction [0.03%]
精确肿瘤学：计算方法整合多组学数据以改善药物反应预测
Guna Gouru
Guna Gouru
Cancer heterogeneity presents a major obstacle to effective drug treatment, emphasizing the need for personalized approaches that can accurately predict drug responses. Advances in high-throughput technologies have driven precision medicine...
Biomarker understanding first lessons from drug development for IgA-driven autoimmune and fibrotic diseases [0.03%]
IgA相关自身免疫和纤维化性疾病药物研发的初步经验对生物标志物认知的意义
Myrthe Alexandra Maria van Delft,Aleksandra Cegiel,Marjolein van Egmond et al.
Myrthe Alexandra Maria van Delft et al.
The concept of personalized medicine and its significant benefits for patients and society was introduced over three decades ago. The Human Genome Project (initiated in 1990 and completed in 2003) greatly accelerated the development of prec...
Artificial intelligence in breast cancer diagnosis: A systematic literature review [0.03%]
乳腺癌诊断中人工智能的应用：系统文献综述
Arslaan Javaeed,Anna Schuh
Arslaan Javaeed
Breast cancer is the second leading cause of cancer-related deaths among women globally and the most prevalent cancer in women. Artificial intelligence (AI)-based frameworks have shown great promise in correctly classifying breast carcinoma...
Accelerating eSource scale-up in oncology clinical trials: The i~HD Task Force initiative [0.03%]
加速肿瘤临床试验中的eSource推广应用:i~HD任务组倡议
Christophe Maes,Dipak Kalra,Tracy Acito et al.
Christophe Maes et al.
eSource - particularly EHR-to-EDC - is an emerging paradigm in clinical research that enables automated transfer of electronic health record (EHR) data into electronic data capture (EDC) systems, with the potential to reduce site burden, im...
Clinically actionable pharmacogenomic landscape of antidepressants and antipsychotics in Qatar: a population-based cohort study [0.03%]
卡塔尔抗抑郁和抗精神病药物的临床可操作药物基因组特征：基于人群队列的研究
Dinesh Velayutham,Kholoud Bastaki,Areeba Irfan et al.
Dinesh Velayutham et al.
Consortia like the Clinical Pharmacogenetic Implementation Consortium (CPIC) and the Dutch Pharmacogenetic Working Group (DPWG) provide clinical guidelines but pharmacogenomics implementation depends on population prevalence of actionable g...
The challenges and opportunities of applying tumour mutational burden analysis to precision cancer medicine [0.03%]
肿瘤突变负荷分析在精准癌症医学中的挑战与机遇
Attia M Elbehi
Attia M Elbehi
The discovery and development of immune checkpoint inhibitors (ICIs) has revolutionised the management of human cancers. However, only a subset of patients responds to ICI therapy, even though immune evasion is a hallmark of cancer. Initial...
Harnessing the power of genomics in hypertension: tip of the iceberg? [0.03%]
利用基因组学的力量治疗高血压：仅仅是冰山一角？
Hafiz Naderi,Helen R Warren,Patricia B Munroe
Hafiz Naderi
Despite the blaze of advancing knowledge on its complex genetic architecture, hypertension remains an elusive condition. Genetic studies of blood pressure have yielded bitter-sweet results thus far with the identification of more than 2,000...
Charles Craddock,Philip Earwaker,Matthew Fittall et al.
Charles Craddock et al.
Vaccines have revolutionised the field of medicine, eradicating and controlling many diseases. Recent pandemic vaccine successes have highlighted the accelerated pace of vaccine development and deployment. Leveraging this momentum, attentio...
Aaron Wenteler,Claudia P Cabrera,Wei Wei et al.
Aaron Wenteler et al.
Artificial intelligence (AI) holds immense promise for accelerating and improving all aspects of drug discovery, not least target discovery and validation. By integrating a diverse range of biological data modalities, AI enables the accurat...
Ethical frameworks of informed consent in the age of pediatric precision medicine [0.03%]
精准医学时代的知情同意伦理框架——以儿童为研究对象的考量
David Chen
David Chen
Precision medicine is an emergent medical paradigm that uses information technology to inform the use of targeted therapies and treatments. One of the first steps of precision medicine involves acquiring the patient's informed consent to pr...