ENDONUCLEASE V: FROM TRANSCRIPTOME REGULATOR TO CHEMICAL BIOLOGY TOOL [0.03%]
从转录组调控到化学生物学工具——端内酶V的功能变迁
Prasanth Thota,Tyson Todd,Devanshi Purohit et al.
Prasanth Thota et al.
Posttranscriptional modifications play a pivotal role in regulating the health and physiology of human cells and adenosine-to-inosine (A-to-I) editing is one of the most abundant of these modifications. Inosine is read as guanosine by the c...
Evolution of a Strategy for the Total Synthesis of the Ganoderma Meroterpenoid Ganoapplanin [0.03%]
马勃Meroterpenoid Ganoapplanin的全合成策略的发展演变
Nicolas Müller,Ondřej Kováč,Alexander Rode et al.
Nicolas Müller et al.
Herein, a detailed account of the efforts leading to the recently published synthesis of the Ganoderma meroterpenoid ganoapplanin, a natural product identified as an inhibitor of T-type voltage-gated calcium channels, is provided. Ganoappla...
Isothiourea-Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6- and 1,4-Additions [0.03%]
异硫脲催化甘氨酸舒夫碱芳基酯的对映选择性化功能化反应(1,6-和1,4-加成)
Lotte Stockhammer,Rebecca Craik,Uwe Monkowius et al.
Lotte Stockhammer et al.
The enantioselective α-functionalisation of glycine Schiff base aryl esters through isothiourea catalysis is successfully demonstrated for 1,6-additions to para-quinone methides (21 examples, up to 95:5 dr and 96:4 er) and 1,4-additions to...