Functional biomaterials for osteoarthritis treatment: From research to application [0.03%]
骨关节炎治疗的功能生物材料：从研究到应用
Yang Lei,Qingfei Zhang,Gaizheng Kuang et al.
Yang Lei et al.
Osteoarthritis (OA) is a common disease that endangers millions of middle-aged and elderly people worldwide. Researchers from different fields have made great efforts and achieved remarkable progress in the pathogenesis and treatment of OA....
Noninvasive platelet membrane-coated Fe3O4 nanoparticles identify vulnerable atherosclerotic plaques [0.03%]
非侵入性血小板膜包被的Fe3O4纳米颗粒识别易损动脉粥样硬化斑块
Yuyu Li,Yujie Wang,Zequn Xia et al.
Yuyu Li et al.
Vulnerable atherosclerotic plaques serve as the primary pathological basis for fatal cardiovascular and cerebrovascular diseases. The precise identification and treatment of these vulnerable plaques hold paramount clinical importance in mit...
Lingyu Sun,Hanxu Chen,Dongyu Xu et al.
Lingyu Sun et al.
In recent years, organs-on-chips have been arousing great interest for their bionic and stable construction of crucial human organs in vitro. Compared with traditional animal models and two-dimensional cell models, organs-on-chips could not...
Roles of Akirin1 in early prediction and treatment of graft kidney ischemia‒reperfusion injury [0.03%]
Akirin1在预测和治疗移植物肾脏缺血再灌注损伤中的作用
Xinyuan Li,Guo Chen,Xiang Zhou et al.
Xinyuan Li et al.
Ferroptosis is a predominant contributor to graft kidney ischemia‒reperfusion injury (IRI), resulting in delayed graft function (DGF). However, much less is known about the early predicting biomarkers and therapeutic targets of DGF, especi...
Stevioside protects against acute kidney injury by inhibiting gasdermin D pathway [0.03%]
stevioside通过抑制gasdermin d通路保护急性肾脏损伤
Ruochen Qiao,Hui Wang,Dasheng Li et al.
Ruochen Qiao et al.
Recent studies indicate a significant upregulation of gasdermin D (GSDMD) in acute kidney injury (AKI), a severe medical condition characterized by high morbidity and mortality globally. In this study, we identified and validated the therap...
Iron-doped nanozymes with spontaneous peroxidase-mimic activity as a promising antibacterial therapy for bacterial keratitis [0.03%]
具有自发类过氧化物酶活性的铁掺杂纳米酶作为细菌性角膜炎的潜在抗菌疗法
Xiwen Geng,Nan Zhang,Zhanrong Li et al.
Xiwen Geng et al.
The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is of great significance for the treatment of bacterial keratitis. In this study, we have developed antibacterial iron-doped nanozym...
Jingbo Li,Lingyu Sun,Feika Bian et al.
Jingbo Li et al.
The islet of Langerhans, functioning as a "mini organ", plays a vital role in regulating endocrine activities due to its intricate structure. Dysfunction in these islets is closely associated with the development of diabetes mellitus (DM). ...
Pathogen-binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites [0.03%]
用于抑制依赖肝素硫酸盐和唾液酸的病毒及原生动物寄生虫感染宿主细胞的病原体结合型纳米颗粒
Adrian Najer
Adrian Najer
Global health faces an immense burden from infectious diseases caused by viruses and intracellular protozoan parasites such as the coronavirus disease (COVID-19) and malaria, respectively. These pathogens propagate through the infection of ...
Digital droplet RT-LAMP increases speed of SARS-CoV-2 viral RNA detection [0.03%]
数字微滴RT-LAMP可提高SARS-CoV-2病毒RNA检测速度
Yuan Yuan,Perry Ellis,Ye Tao et al.
Yuan Yuan et al.
Nucleic acid amplification testing (NAAT) remains one of the most reliable methods for pathogen identification. However, conventional bulk NAATs may not be sufficiently fast or sensitive enough for the detection of clinically-relevant patho...
Reconstruction of the alveolar-capillary barrier in vitro based on a photo-responsive stretchable Janus membrane [0.03%]
基于光响应可拉伸Janus膜的体外肺泡-毛细血管屏障重建研究
Changmin Shao,Ting Cao,Xiaochen Wang et al.
Changmin Shao et al.
The lung is the respiratory organ of the human body, and the alveoli are the most basic functional units of the lung. Herein, a photo-responsive stretchable Janus membrane was proposed for the reconstruction of the alveolar-capillary barrie...