Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1-STING Inflammatory Axis [0.03%]
磁重编程巨噬细胞通过TRPC1-STING炎性轴刺激乳腺癌细胞的吞噬作用
Viresh Krishnan Sukumar,Yee Kit Tai,Jan Nikolas Iversen et al.
Viresh Krishnan Sukumar et al.
The reprogramming of tumor-associated macrophages (TAMs) from a pro-tumoral M2 to an anti-tumoral M1 phenotype is an attractive therapeutic strategy whose clinical translation is undermined by the systemic toxicity of currently available ph...
MacAma: Multi-AI Agent as a Co-Scientist for Automated Meta-Analysis [0.03%]
MacAma：作为共科学家的多AI代理自动化-meta-分析系统
Yilin Yuan,Pingping Li,Yang Wang et al.
Yilin Yuan et al.
Meta-analysis is fundamental to evidence-based medicine, yet traditional workflows remain labor-intensive and susceptible to bias. Although LLM-based research agents offer opportunities for workflow automation, they often lack the data fide...
Ting Cao,Chen Yang,Zhengyang Wang et al.
Ting Cao et al.
As a crucial biological material, the extracellular matrix (ECM) constitutes a major part of the extracellular microenvironment, offering both structural support and essential biological signals to surrounding cells. Research into ECM prope...
Metabolic Profiling Reveals Organ-Specific Molecular Pathologies and Aging-Associated Biomarkers in Progeroid Laminopathy [0.03%]
代谢轮廓分析揭示了早衰型胶原病的器官特异性分子病理和衰老相关生物标志物
Lidan Hu,Xiaoyang Zhao,Yingxian Zhang et al.
Lidan Hu et al.
The molecular mechanisms linking premature and physiological aging remain incompletely understood. Here, we present a cross-species, multi-organ metabolic atlas of progeroid laminopathy (PL) generated through integrated lipidomic and metabo...
Yixiang Zhang,Yawei Du,Shifeng Ling et al.
Yixiang Zhang et al.
Adipose-derived stem cells (ADSCs) are central regulators of adipose tissue homeostasis and regenerative capacity. Accumulating evidence indicates that aging and obesity profoundly impair ADSC function, through progressive mitochondrial dys...
Microfluidic Electrospray Microcapsules With Spatiotemporal Release of Asiatic Acid and Baicalein Nanocarriers for Wound Healing [0.03%]
用于伤口愈合的时空释放 Asiatic 酸和 baicalin 纳米载体的微流体电喷雾微胶囊
Zhiqiang Luo,Lingbao Zeng,Xinyu Zhu et al.
Zhiqiang Luo et al.
Synergy therapy of Chinese herbs is an effective strategy for wound repair and its further development focuses on the chronological release of specific herbs with healing proceeding. Herein, we report a novel asiatic acid/baicalein nanocarr...
Flexible Porous Pomelo Pith Derived Janus Liquid Metal and Adhesive Hydrogel Hybrid Electronic Skins [0.03%]
一种基于液态金属和黏附性水凝胶的janus型电子皮肤（灵感来源于可拉伸多孔柚子囊）
Jinbo Li,Wenzhao Li,Hongbo Zhang et al.
Jinbo Li et al.
Liquid metal (LM)-derived electronic skin (e-skin) exhibits significant potential in the domains of human-machine interfaces, health monitoring and energy management. Herein, we introduce a cost-effective paradigm of LMs-derived e-skin feat...
Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications [0.03%]
用于组织工程应用的冷冻制微孔生物材料
Shuangshuang Miao,Xingkui Guo,Chenhui Bai et al.
Shuangshuang Miao et al.
Tissue engineering holds immense promise to revolutionize regenerative medicine by enabling the fabrication of functional, patient-specific tissues and organs for clinical translation, yet it continues to face persistent challenges in desig...
Ruixing Shui,Fan Ding,Dapeng Li et al.
Ruixing Shui et al.
Spinal cord injury (SCI), which is a severe complication of spinal fractures, often causes the dysfunction of the spinal cord and results in sensory and motor abnormalities. Current clinical treatments-including medication, decompression su...
Miaomiao Wang,Qianwei Su,Yuezhou Wu et al.
Miaomiao Wang et al.
Bone injuries, particularly those associated with an aging global population, pose a persistent and complex clinical challenge. Current gold-standard treatments such as autografts, allografts, and metal implants, are often limited by immune...