Integrating Single-Cell and Spatial Transcriptomics Reveals NK Cell Subpopulations Associated With Immunotherapy for Melanoma [0.03%]
单细胞和空间转录组学整合分析揭示了与黑色素瘤免疫治疗相关的NK细胞亚群
Zhicheng Hu,Yongfei Chen,Hao Yang et al.
Zhicheng Hu et al.
Immune checkpoint inhibitors (ICI) have demonstrated prolonged efficacy in certain melanoma patients, yet a significant portion of patients do not experience clinical improvement, with the mechanisms underlying this resistance still not ful...
Polydopamine-Integrated Porcine Small Intestine Decellularized Extracellular Matrix Hydrogel Microparticles for Wound Healing [0.03%]
聚多巴胺整合的脱细胞小肠基质微颗粒促进伤口愈合
Shangrui Rao,Hongzheng Li,Letian Meng et al.
Shangrui Rao et al.
Decellularized materials show good prospects in wound healing. Current research focuses on developing advanced decellularized scaffolds and designing multifunctional structures to enhance tissue repair. In this study, a kind of polydopamine...
Ultrasound-Responsive Microcapsules Delivering Oxygen and Traditional Chinese Medicine for Wound Healing [0.03%]
一种用于伤口愈合的超声波响应型微胶囊氧气和传统中药递送系统
Baojie Wen,Danqing Huang,Chuanhui Song et al.
Baojie Wen et al.
Hydrogel microparticles with different actives encapsulation have reliable efficacy in wound repair, and the challenge is to improve the active substance to improve the efficacy. Here, a novel ultrasonic responsive core-shell microcapsule d...
Cuicui Wang,Meng Shi,Tiandao Li et al.
Cuicui Wang et al.
Human osteoarthritis (OA) displays sex-specific patterns in its clinical presentation. Key features of the disease-such as prevalence, age of onset, progression, and response to treatment-vary between males and females. These differences ha...
Antibacterial and Proangiogenic Hydrogel Microneedle Patches for Wound Healing [0.03%]
具有抗菌和促血管生成的水凝胶微针贴片促进伤口愈合
Junyi Zhang,Yunjie Shi,Yixin Zhang et al.
Junyi Zhang et al.
Wounds represent a global and challenging healthcare issue, resulting in a cascade of consequences. Despite the widespread application of existing wound dressings, their performance and efficacy are significantly limited in terms of biocomp...
Advancements and Future Perspectives of Microfluidic Technology in Pediatric Healthcare [0.03%]
微流体技术在儿科医疗中的进展与未来展望
Xuting Zhang,Andong Liu,Yanke Wang et al.
Xuting Zhang et al.
Due to the ability to precisely control and manipulate fluids at the microscale, microfluidics provides unmatched advantages such as reduced sample size, rapid analysis, and enhanced sensitivity. Microfluidic technology has emerged as a rev...
Pollen Integrated Hydrogel Patches With Hierarchical Structures and Spatio-Temporal Actives Release for Wound Healing [0.03%]
具有层次结构和时空活性释放的集成花粉水凝胶贴片用于伤口愈合
Xinyu Zhu,Lijun Cai,Yu Wang et al.
Xinyu Zhu et al.
Hydrogel patches have been serving as powerful tools for wound healing. Scientific attention in this field is focused on imparting the patches with novel structures, functions, and actives for promoting wound healing. In this paper, we have...
Mussel-Inspired Adhesive and Tough Hydrogel Based on Silk-Triggered Dopamine Polymerization for Wound Healing [0.03%]
一种受 Mussel(淡水贻贝)启发的丝素蛋白触发多巴聚合的伤口粘合水凝胶及其应用
Yu-Ge Wang,Ting-Ting Zeng,Hao Wu et al.
Yu-Ge Wang et al.
Tissue engineering is a great alternative to repair and regenerate damaged tissues and organs. Hydrogels are promising materials for tissue repair, but optimizing their various functions-such as adhesion, mechanical properties, and vascular...
Mechanistic Insights Into Overloading-Induced Terminal Differentiation of TMJ Condylar Cartilage at the Single Cell Level [0.03%]
单细胞水平下颞下颌关节髁突软骨过载诱导终末分化的机制研究
Dian Zhou,Yiling Jiang,Yingcui Li et al.
Dian Zhou et al.
The incidence of temporomandibular joint (TMJ) degeneration has been steadily increasing, with overloading identified as a major risk factor. This condition often leads to condylar cartilage degeneration, significantly affecting patients' q...
Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non-Targeted and Targeted Metabolomics Approach [0.03%]
基于非靶标和靶向代谢组学方法的慢性化脓性中耳炎差异代谢标志物筛选
Lidan Hu,Yifan Zhu,Chengpeng Wu et al.
Lidan Hu et al.
Chronic suppurative otitis media (CSOM) is a leading cause of hearing loss and otorrhea, and when associated with cholesteatoma, it can pose a serious threat to patients' lives. This study aims to identify differences in tissue metabolites ...