Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non-Targeted and Targeted Metabolomics Approach [0.03%]
基于非靶标和靶向代谢组学方法的慢性化脓性中耳炎差异代谢标志物筛选
Lidan Hu,Yifan Zhu,Chengpeng Wu et al.
Lidan Hu et al.
Chronic suppurative otitis media (CSOM) is a leading cause of hearing loss and otorrhea, and when associated with cholesteatoma, it can pose a serious threat to patients' lives. This study aims to identify differences in tissue metabolites ...
Permeable Hydrogel Encapsulated Osteosarcoma-on-a-Chip for High-Throughput Multi-Drugs Screening [0.03%]
用于高通量多药筛查的可渗透水凝胶包封的骨肉瘤芯片
Haiwen Su,Yuanhai Chen,Zhiyan Xuan et al.
Haiwen Su et al.
Pharmacological chemotherapy remains a cornerstone in treating osteosarcoma (OS), where the application of drug combinations not only enhances therapeutic efficacy but also mitigates adverse side effects. However, the absence of an efficien...
Conductive Nerve Conduits With Orientated Topological Structures From Ice-Templating Technology [0.03%]
冰模板技术制造具有有序拓扑结构的导电神经导管
Hui Zhang,Kaichen Wang,Dongyu Xu et al.
Hui Zhang et al.
Artificial nerve conduits hold significant promise for treating nerve injuries, with researchers focusing on simplifying techniques to harness microstructures and functions to improve their therapeutic outcomes. Here, a type of conductive n...
Nimet Temur,Esma Eryilmaz- Eren,Ilhami Celik et al.
Nimet Temur et al.
Mycobacterium tuberculosis (MTB) remains a global health issue and continues to rank among the leading causes of death from infectious diseases worldwide. Its persistence is primarily attributed to the microorganism's challenging and time-c...
Research Progress of Osteoarthritis Treatment by Low Intensity Pulsed Ultrasound [0.03%]
低强度脉冲超声治疗骨关节炎研究进展
Mengtong Guan,Xinyu Zhang,Xinhe Li et al.
Mengtong Guan et al.
With the intensification of global population aging, osteoarthritis (OA) has emerged as a major socioeconomic burden requiring urgent therapeutic interventions. Low-intensity pulsed ultrasound (LIPUS), a non-invasive physical therapy modali...
The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives [0.03%]
微流控芯片在泌尿系统肿瘤中的应用：最新进展与未来展望
Jiafu Liu,Xiao Zhi,Xiaolan Fang et al.
Jiafu Liu et al.
The research of primary urological cancers, including bladder cancer (BCa), prostate cancer (PCa), and renal cancer (RCa), has developed rapidly. Microfluidic technology provides a good variety of benefits compared to the heterogeneity of a...
Polyamine Metabolism Promotes the Progression of Thyroid Carcinoma by Regulating the Immune Phenotype of Tumor Associated Macrophages [0.03%]
多胺代谢通过调节肿瘤相关巨噬细胞的免疫表型促进甲状腺癌进展
Haoran Ding,Lingling Xue,Shaoshi Zhu et al.
Haoran Ding et al.
Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis. Macrophages also greatly influence tumor progression by regulating the immune m...
Targeting KRAS Sensitizes Ferroptosis by Coordinately Regulating the TCA Cycle and Nrf2-SLC7A11-GPX4 Signaling in Hepatocellular Carcinoma [0.03%]
靶向KRAS通过协调调节TCA循环和Nrf2-SLC7A11-GPX4信号促进肝细胞癌铁死亡敏感性
Jiaxin Zhang,Zuojia Liu,Wenjing Zhao et al.
Jiaxin Zhang et al.
Oncogenic KRAS, a notorious driver of cancer progression, remains a therapeutic challenge. In hepatocellular carcinoma (HCC), KRAS overexpression correlates with tumor aggressiveness. Here, we demonstrate that NSC48160 induces HCC cell deat...
MXene-Based Photothermal-Responsive Injectable Hydrogel Microsphere Modulates Physicochemical Microenvironment to Alleviate Osteoarthritis [0.03%]
MXene基光热响应注射型水凝胶微球调控物理化学微环境以缓解骨关节炎
Zehua Gong,Linjie Chen,Xiaolei Zhou et al.
Zehua Gong et al.
Osteoarthritis (OA) is a physical lubrication microenvironment-inadequate disease accompanied by a sustained chronic chemical inflammation microenvironment and the progression of articular cartilage destruction. Despite the promising OA tre...
Self-Assembled Hydroxypropyl Celluloses With Structural Colors for Biomedical Applications [0.03%]
具有结构色的羟丙基纤维素自装体系及其生物医学应用
Zhuohao Zhang,Luoran Shang
Zhuohao Zhang
Hydroxypropyl cellulose (HPC), a cellulose derivative with biocompatibility, edibility, and exceptional solubility in many polar solvents, holds significant potential for biomedical applications. Within a specific concentration range, HPC u...