Xiang Lin,Lijun Cai,Xinyue Cao et al.
Xiang Lin et al.
Stimuli-responsive "smart" hydrogel biomaterials have attracted great attention in the biomedical field, especially in designing novel on-demand drug delivery systems. As a handful natural biomaterial approved by US Food and Drug Administra...
Multidimensional landscape of non-alcoholic fatty liver disease-related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives [0.03%]
大规模组学数据绘制非酒精性脂肪肝相关疾病谱的多维度图谱： profiling证据与新视野
Zhengyi Zhu,Yuyan Chen,Xueqian Qin et al.
Zhengyi Zhu et al.
Characterized by hepatic lipid accumulation, non-alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that could promote the progression of non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinom...
Dongyu Xu,Hui Zhang,Yu Wang et al.
Dongyu Xu et al.
Nerve injury caused by trauma or iatrogenic trauma can lead to loss of sensory and motor function, resulting in paralysis of patients. Inspired by endogenous bioelectricity and extracellular matrix, various external physical and chemical st...
TP53 mutation-related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles [0.03%]
基于组学特征的TP53突变相关衰老是肝细胞癌患者预后的标志
Yu-Yan Chen,Zheng-Yi Zhu,Tao Ma et al.
Yu-Yan Chen et al.
TP53 mutation frequently occurs in hepatocellular carcinoma (HCC). Senescence also plays a vital role in the ongoing process of HCC. P53 is believed to regulate the advancement of senescence in HCC. However, the exact mechanism of TP53 muta...
Single therapeutic dose of an antiviral UL29 siRNA swarm diminishes symptoms and viral load of mice infected intranasally with HSV-1 [0.03%]
单一治疗剂量的抗病毒UL29 siRNA群可减轻鼻内感染HSV-1的小鼠的症状和病毒载量
Tuomas Lasanen,Fanny Frejborg,Liisa M Lund et al.
Tuomas Lasanen et al.
Herpes simplex virus type 1 (HSV-1) is a human pathogen that causes recurrent infections. Acyclovir-resistant strains exist and can cause severe complications, which are potentially untreatable with current therapies. We have developed siRN...
Danqing Huang,Lijun Cai,Ning Li et al.
Danqing Huang et al.
Micro- and nanorobots (MNRs) propelled by external actuations have broad potential in biomedical applications. Among the numerous external excitations, ultrasound (US) features outstanding practical significance with merits of its noninvasi...
Xiaocheng Wang,Yazhi Sun,Daniel Wangpraseurt
Xiaocheng Wang
Engineered biohybrids have recently emerged as innovative biomimetic platforms for cancer therapeutic applications. Particularly, engineered photoresponsive biohybrids hold tremendous potential against tumors due to their intriguing biomime...
Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature [0.03%]
基于血管的器官芯片技术在生物医学研究与药物开发中的应用
Diosangeles Soto Veliz,Kai-Lan Lin,Cecilia Sahlgren
Diosangeles Soto Veliz
Current biomedical models fail to replicate the complexity of human biology. Consequently, almost 90% of drug candidates fail during clinical trials after decades of research and billions of investments in drug development. Despite their ph...
Phospholipid-based liposomes are among the most successful nanodrug delivery systems in clinical use. However, these conventional liposomes present significant challenges including low drug-loading capacity and issues with drug leakage. Dru...