Proactive personalized early warning systems: the next frontier in climate-health preparedness [0.03%]
主动个性化早期预警系统：气候与健康准备工作的下一个前沿领域
Tao Liu,Hejie Wang,Cunrui Huang et al.
Tao Liu et al.
Severe trauma care: advances and future directions in diagnostic and therapeutic techniques and information technology support [0.03%]
严重创伤治疗：诊断和治疗方法及信息技术支持的进展与未来方向
Feifei Jin,Shu Li,Xuemin Zhang et al.
Feifei Jin et al.
Severe trauma continues to rank among the leading causes of mortality and permanent disability globally, posing an intractable public health challenge that mandates prompt sophisticated and multidisciplinary intervention. Notably, the "Chin...
Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases [0.03%]
母婴间微生物垂直传播：时间、决定因素及其对后代胃肠道疾病易感性的影响
Ruqiao Duan,Kun Wang,Liping Duan
Ruqiao Duan
The establishment of the early-life microbiota is profoundly shaped by microbial vertical transmission from mother to offspring. This review synthesized the current understanding of the timing, determinants, and health implications of mothe...
Zhuoran Xu,Wenjie Zhang
Zhuoran Xu
Jaw bone defects impair oral function and facial aesthetics, reducing patients' quality of life. While significant progress has been achieved in systemic skeletal repair, jaw bone regeneration remains challenging due to its distinct biologi...
Current status, development and challenges in the treatment of chronic graft-versus-host disease [0.03%]
慢性移植物抗宿主病的治疗现状、进展和挑战
Hongru Chen,Xiaodong Mo
Hongru Chen
Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays [0.03%]
通过高通量测序技术解读DNA代谢及其临床意义
Jingzhi Luo,Fanyu Zhao,Shuyan Lin et al.
Jingzhi Luo et al.
Eukaryotic DNA metabolism, involving DNA replication and damage repair, ensures the faithful transmission of genetic information and is essential for maintaining genome integrity. Consequently, its dysregulation contributes to a broad spect...
The nitrate-Sialin axis: a new target for regulation of macrophage metabolic reprogramming and metabolic homeostasis [0.03%]
硝酸盐-Sialin轴：调控巨噬细胞代谢重编程和代谢稳态的新靶点
Yao Feng,Yijia Shi,Wudi Zhai et al.
Yao Feng et al.
Shuren Zhang,Siyong Shen,Jiangsheng Li et al.
Shuren Zhang et al.
Combined radiotherapy and chemotherapy remain central to cancer treatment, with metallodrugs - most notably platinum agents - playing indispensable roles in clinical regimens. However, systemic toxicity and limited tumor selectivity continu...
Advances in the pathogenesis and clinical management of pulmonary hypertension [0.03%]
肺动脉高压发病机制及临床治疗的新进展
Yi Yan,Zhuoyuan Xu,Yanghanyue Zhou et al.
Yi Yan et al.
Pulmonary hypertension (PH) is a severe cardiopulmonary disorder characterized by pulmonary vascular remodeling, which leads to increased pulmonary vascular resistance (PVR), right ventricular (RV) hypertrophy, and ultimately heart failure ...
How to efficiently establish animal models of cholangiocarcinoma: challenges and inspiration [0.03%]
如何高效建立胆管癌动物模型：挑战与启发
Ruiqiang Gou,Ping Yue,Peng Liu et al.
Ruiqiang Gou et al.
Cholangiocarcinoma (CCA) consists of a class of malignant tumors of the biliary system, with a rising incidence and carries a poor prognosis. Developing reliable animal models of CCA is crucial to elucidate the pathogenesis, identify novel ...