A systems approach evaluating the impact of SARS-CoV-2 variant of concern mutations on CD8+ T cell responses [0.03%]
系统评估SARS-CoV-2变异株的关切突变对CD8+t细胞反应的影响
Paul R Buckley,Chloe H Lee,Agne Antanaviciute et al.
Paul R Buckley et al.
T cell recognition of SARS-CoV-2 antigens after vaccination and/or natural infection has played a central role in resolving SARS-CoV-2 infections and generating adaptive immune memory. However, the clinical impact of SARS-CoV-2-specific T c...
Correction to: Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor [0.03%]
Correction to: TIM-3受体靶向的新型免疫疗法savapritumab(SAB007)的作用机制及活性特征
[This corrects the article DOI: 10.1093/immadv/ltac019.]. © The Author(s) 2023. Published by Oxford University Press on behalf of the British Society fo...
Published Erratum
Immunotherapy advances. 2023 Feb 18;3(1):ltad002. DOI:10.1093/immadv/ltad002 2023
Correction to: Peripheral blood persistence and expansion of transferred non-genetically modified Natural Killer cells might not be necessary for clinical activity [0.03%]
Correction to: 嵌合抗原受体修饰的自然杀伤细胞治疗实体瘤的安全性研究：I 期临床试验结果
[This corrects the article DOI: 10.1093/immadv/ltac024.]. © The Author(s) 2023. Published by Oxford University Press on behalf of the British Society fo...
Published Erratum
Immunotherapy advances. 2023 Feb 18;3(1):ltad003. DOI:10.1093/immadv/ltad003 2023
Stratification of PD-1 blockade response in melanoma using pre- and post-treatment immunophenotyping of peripheral blood [0.03%]
基于外周血免疫分型的黑色素瘤PD-1阻断反应分类研究
Natalie M Edner,Elisavet Ntavli,Lina Petersone et al.
Natalie M Edner et al.
Efficacy of checkpoint inhibitor therapies in cancer varies greatly, with some patients showing complete responses while others do not respond and experience progressive disease. We aimed to identify correlates of response and progression f...
A recombinant Der p 1-specific allergen-toxin demonstrates superior killing of allergen-reactive IgG+ hybridomas in comparison to its recombinant allergen-drug conjugate [0.03%]
一种Der p 1特异性过敏原毒素的重组形式比其过敏原-药物偶联物更有效地杀灭过敏原反应性IgG+杂交瘤细胞
A K Daramola,O A Akinrinmade,E A Fajemisin et al.
A K Daramola et al.
Introduction: Current treatments for asthma help to alleviate clinical symptoms but do not cure the disease. In this study, we explored a novel therapeutic approach for the treatment of house dust mite allergen Der p 1ind...
Cornelis J M Melief
Cornelis J M Melief
During the last two decades, two main schools of modern immunotherapy have come to the forefront. The chimeric anti-CD20 antibody rituximab that was introduced for the treatment of refractory follicular lymphoma in 1998 was one of the first...
Peripheral blood persistence and expansion of transferred non-genetically modified Natural Killer cells might not be necessary for clinical activity [0.03%]
外周血输注的非基因改造的自然杀伤细胞的持久性和扩增可能不是临床起效的前提条件
Lucia Silla
Lucia Silla
Natural killer (NK) cells are innate lymphocytes that react without previous exposition to virus infected or malignant cells and stimulate adaptive immune response to build a long-lasting immunity against it. To that end, tissue resident NK...
Rifat S Rahman,Duane R Wesemann
Rifat S Rahman
Allergen immunotherapy (AIT) is the only disease-modifying therapy for allergic disease. Through repeated inoculations of low doses of allergen-either as whole proteins or peptides-patients can achieve a homeostatic balance between inflamma...
Stefan Barth,Krupa Naran
Stefan Barth
Immune checkpoint inhibitors are one of the most remarkable immunomodulatory therapies of current times. Sabatolimab is a high-affinity, humanized anti-TIM-3 monoclonal antibody currently in development for patients with myeloproliferative ...
Vitamin D3 replacement enhances antigen-specific immunity in older adults [0.03%]
维生素D3替代增强老年人的特异性抗原免疫反应
Emma S Chambers,Milica Vukmanovic-Stejic,Carolin T Turner et al.
Emma S Chambers et al.
Introduction: Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varic...