A recombinant Der p 1-specific allergen-toxin demonstrates superior killing of allergen-reactive IgG+ hybridomas in comparison to its recombinant allergen-drug conjugate [0.03%]
一种Der p 1特异性过敏原毒素的重组形式比其过敏原-药物偶联物更有效地杀灭过敏原反应性IgG+杂交瘤细胞
A K Daramola,O A Akinrinmade,E A Fajemisin et al.
A K Daramola et al.
Introduction: Current treatments for asthma help to alleviate clinical symptoms but do not cure the disease. In this study, we explored a novel therapeutic approach for the treatment of house dust mite allergen Der p 1ind...
Cornelis J M Melief
Cornelis J M Melief
During the last two decades, two main schools of modern immunotherapy have come to the forefront. The chimeric anti-CD20 antibody rituximab that was introduced for the treatment of refractory follicular lymphoma in 1998 was one of the first...
Peripheral blood persistence and expansion of transferred non-genetically modified Natural Killer cells might not be necessary for clinical activity [0.03%]
外周血输注的非基因改造的自然杀伤细胞的持久性和扩增可能不是临床起效的前提条件
Lucia Silla
Lucia Silla
Natural killer (NK) cells are innate lymphocytes that react without previous exposition to virus infected or malignant cells and stimulate adaptive immune response to build a long-lasting immunity against it. To that end, tissue resident NK...
Rifat S Rahman,Duane R Wesemann
Rifat S Rahman
Allergen immunotherapy (AIT) is the only disease-modifying therapy for allergic disease. Through repeated inoculations of low doses of allergen-either as whole proteins or peptides-patients can achieve a homeostatic balance between inflamma...
Stefan Barth,Krupa Naran
Stefan Barth
Immune checkpoint inhibitors are one of the most remarkable immunomodulatory therapies of current times. Sabatolimab is a high-affinity, humanized anti-TIM-3 monoclonal antibody currently in development for patients with myeloproliferative ...
Vitamin D3 replacement enhances antigen-specific immunity in older adults [0.03%]
维生素D3替代增强老年人的特异性抗原免疫反应
Emma S Chambers,Milica Vukmanovic-Stejic,Carolin T Turner et al.
Emma S Chambers et al.
Introduction: Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varic...
DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease [0.03%]
DNAM1和TIGIT平衡T细胞反应，特应性皮炎患者T细胞中低TIGIT表达对应炎症反应
Marleen E Jacobs,Juliëtte N Pouw,Michel A Olde Nordkamp et al.
Marleen E Jacobs et al.
Objectives: Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can interact with the stimulatory receptor DNAM1 or inhibitory receptor T...
The MARVEL trial: a phase 2b randomised placebo-controlled trial of oral MitoQ in moderate ulcerative colitis [0.03%]
MARVEL试验：MitoQ口服治疗中度溃疡性结肠炎的2b期随机双盲安慰剂对照试验
Emily Gwyer Findlay,Greg Sutton,Gwo-Tzer Ho
Emily Gwyer Findlay
Ulcerative colitis (UC) is an inflammatory disease of the large bowel which is characterised by dysregulated immunity and death to epithelial cells in the bowel, leading to prolonged inflammation. This can ultimately lead to surgery to remo...
Beyond Ipilimumab: a review of immunotherapeutic approaches in clinical trials in melanoma [0.03%]
伊匹单抗之外：黑色素瘤临床试验中的免疫治疗综述
Gary Middleton
Gary Middleton
In this first in a series of 'Trials Watch' articles, we briefly review a highly selected set of clinical trials that are currently recruiting or about to open to recruitment in melanoma, the disease first transformed by the introduction of...
Tim Elliott
Tim Elliott