Establishment of humanised xenograft models as in vivo study for lung metastasis of osteosarcoma [0.03%]
人源化异种移植模型的建立作为骨肉瘤肺转移的体内研究
Farhana Khamarudin,Mudiana Muhamad,Mohamad Johari Ibahim et al.
Farhana Khamarudin et al.
Humanised xenograft models and cancer cell lines are widely used for preclinical drug evaluation, biological studies, and targeted therapy strategies in cancer research. A humanised mouse model is a laboratory mouse that has been geneticall...
Tumour-reactive plasma cells in antitumour immunity: current insights and future prospects [0.03%]
肿瘤反应性浆细胞在抗肿瘤免疫中的作用：当前见解与未来前景
Peng Chen,Yiwei Chu,Ronghua Liu
Peng Chen
Tumour-reactive plasma cells (TRPCs) have been reported to be positively associated with the long-term survival of patients with various cancers. However, unlike tumour-specific antigen (TSA)-induced T cells which have precise effects again...
Dharanidharan Ramamurthy,Trishana Nundalall,Sanele Cingo et al.
Dharanidharan Ramamurthy et al.
Immunotherapies are disease management strategies that target or manipulate components of the immune system. Infectious diseases pose a significant threat to human health as evidenced by countries continuing to grapple with several emerging...
Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function [0.03%]
Janus激酶抑制剂改善STAT3功能增强型患者的临床症状
Shuya Kaneko,Fumiaki Sakura,Kay Tanita et al.
Shuya Kaneko et al.
Germline gain-of-function (GOF) variants in the signal transducer and activator of transcription 3 (STAT3) gene is an inborn error of immunity presenting with autoimmunity and lymphoproliferation. Symptoms can vary widely, and no effective ...
Pharmacokinetics, safety, and efficacy of 20% subcutaneous immunoglobulin (Ig20Gly) administered weekly or every 2 weeks in Japanese patients with primary immunodeficiency diseases: a phase 3, open-label study [0.03%]
日本原发性免疫缺陷病患者中20%皮下注射人免疫球蛋白(Ig20Gly)每周或每2周给药的药代动力学、安全性和有效性：一项III期开放标签研究
Hirokazu Kanegane,Akifumi Endo,Satoshi Okada et al.
Hirokazu Kanegane et al.
This phase 3, open-label, multidose study (NCT04346108) evaluated the pharmacokinetics, safety, tolerability, and efficacy of immunoglobulin subcutaneous (human) 20% solution (Ig20Gly) administered weekly and every 2 weeks in Japanese patie...
Ex vivo comparative immunogenicity assessment (EVCIA) to determine relative immunogenicity in chronic plaque psoriasis in participants receiving Humira® or undergoing repeated switches between Humira® and AVT02 [0.03%]
用于评估使用Humira®或在Humira®和AVT02之间进行重复转换的受试者慢性斑块状牛皮癣的相对免疫原性的离体比较免疫原性评估（EVCIA）
Kathleen Richter,Halimu N Haliduola,Jana Schockaert et al.
Kathleen Richter et al.
Immunogenicity against biologic medicines is ubiquitous, and it is traditionally measured by the final humoral response. However, the onset of a sustained immunogenic response begins at the cellular level with activation of T cells and matu...
Matthew D Blunt,Salim I Khakoo
Matthew D Blunt
Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and anti-viral immune responses. Their ability to rapidly destroy abnormal cells and to enhance the anti-cancer function of dendritic cells, CD8+ ...
Shania Makker,Charlotte Galley,Clare L Bennett
Shania Makker
The concept of a therapeutic cancer vaccine to activate anti-tumour immunity pre-dates innovations in checkpoint blockade immunotherapies. However, vaccination strategies have yet to show the hoped-for successes in patients, and unanswered ...
Strategies to overcome low MHC-I expression in paediatric and adult tumours [0.03%]
克服儿童和成人肿瘤中低MHC-I表达的策略
J Guillaume,A Perzolli,M Boes
J Guillaume
Immunotherapy has made significant advancements in cancer treatments, improving patients' survival rates and quality of life. Several challenges still need to be addressed, which include the considerable fraction of incomplete curative resp...
NLRP3 inflammasome activation in sensory neurons promotes chronic inflammatory and osteoarthritis pain [0.03%]
感觉神经元中NLRP3炎症小体的活化促进慢性炎性关节痛和骨关节炎疼痛
Patrícia Silva Santos Ribeiro,Hanneke L D M Willemen,Sabine Versteeg et al.
Patrícia Silva Santos Ribeiro et al.
Pain is one of the most debilitating symptoms in rheumatic diseases. Pain often persists after total knee replacement in osteoarthritis, or when inflammation is minimal/absent in rheumatoid arthritis. This suggests that pain transitions to ...