Pharmacokinetics, safety, and efficacy of 20% subcutaneous immunoglobulin (Ig20Gly) administered weekly or every 2 weeks in Japanese patients with primary immunodeficiency diseases: a phase 3, open-label study [0.03%]
日本原发性免疫缺陷病患者中20%皮下注射人免疫球蛋白(Ig20Gly)每周或每2周给药的药代动力学、安全性和有效性：一项III期开放标签研究
Hirokazu Kanegane,Akifumi Endo,Satoshi Okada et al.
Hirokazu Kanegane et al.
This phase 3, open-label, multidose study (NCT04346108) evaluated the pharmacokinetics, safety, tolerability, and efficacy of immunoglobulin subcutaneous (human) 20% solution (Ig20Gly) administered weekly and every 2 weeks in Japanese patie...
Ex vivo comparative immunogenicity assessment (EVCIA) to determine relative immunogenicity in chronic plaque psoriasis in participants receiving Humira® or undergoing repeated switches between Humira® and AVT02 [0.03%]
用于评估使用Humira®或在Humira®和AVT02之间进行重复转换的受试者慢性斑块状牛皮癣的相对免疫原性的离体比较免疫原性评估（EVCIA）
Kathleen Richter,Halimu N Haliduola,Jana Schockaert et al.
Kathleen Richter et al.
Immunogenicity against biologic medicines is ubiquitous, and it is traditionally measured by the final humoral response. However, the onset of a sustained immunogenic response begins at the cellular level with activation of T cells and matu...
Matthew D Blunt,Salim I Khakoo
Matthew D Blunt
Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and anti-viral immune responses. Their ability to rapidly destroy abnormal cells and to enhance the anti-cancer function of dendritic cells, CD8+ ...
Shania Makker,Charlotte Galley,Clare L Bennett
Shania Makker
The concept of a therapeutic cancer vaccine to activate anti-tumour immunity pre-dates innovations in checkpoint blockade immunotherapies. However, vaccination strategies have yet to show the hoped-for successes in patients, and unanswered ...
Strategies to overcome low MHC-I expression in paediatric and adult tumours [0.03%]
克服儿童和成人肿瘤中低MHC-I表达的策略
J Guillaume,A Perzolli,M Boes
J Guillaume
Immunotherapy has made significant advancements in cancer treatments, improving patients' survival rates and quality of life. Several challenges still need to be addressed, which include the considerable fraction of incomplete curative resp...
NLRP3 inflammasome activation in sensory neurons promotes chronic inflammatory and osteoarthritis pain [0.03%]
感觉神经元中NLRP3炎症小体的活化促进慢性炎性关节痛和骨关节炎疼痛
Patrícia Silva Santos Ribeiro,Hanneke L D M Willemen,Sabine Versteeg et al.
Patrícia Silva Santos Ribeiro et al.
Pain is one of the most debilitating symptoms in rheumatic diseases. Pain often persists after total knee replacement in osteoarthritis, or when inflammation is minimal/absent in rheumatoid arthritis. This suggests that pain transitions to ...
Impact of Fc receptors and host characteristics on myeloid phagocytic response to rituximab-treated 3D-cultured B-cell lymphoma [0.03%]
Fc受体和宿主特性对利妥昔单抗治疗的三维培养B细胞淋巴瘤的髓系吞噬反应的影响
Sandra Kleinau
Sandra Kleinau
Antibody-based immunotherapy is successful in treating cancer, but its effectiveness varies among patients. Therefore, understanding myeloid phagocytic responses to therapeutic antibodies is critical. Immunoglobulin Fc receptors and host ch...
Human infection challenge in the pandemic era and beyond, HIC-Vac annual meeting report, 2022 [0.03%]
大流行时代的人感染攻击性试验国际研讨会（HIC-VAC年度会议报告）2022年版
Megan V C Barnes,Anika Mandla,Emma Smith et al.
Megan V C Barnes et al.
HIC-Vac is an international network of researchers dedicated to developing human infection challenge studies to accelerate vaccine development against pathogens of high global impact. The HIC-Vac Annual Meeting (3rd and 4th November 2022) b...
Ester Gea-Mallorquí,Sarah Rowland-Jones
Ester Gea-Mallorquí
Lentivectors (LVs) induce sustained transgene expression and are attractive vaccine platforms for complex immune scenarios like cancer and persistent infections. This review summarises the literature on lentivectors with potential uses for ...
Efficacy of PD-1 checkpoint inhibitor therapy in melanoma and beyond: are peripheral T cell phenotypes the key? [0.03%]
PD-1检查点抑制剂治疗黑色素瘤及其他疾病的有效性：周边T细胞表型是关键因素吗？
Katie R Flaherty,Stephanie Kucykowicz,Johannes Schroth et al.
Katie R Flaherty et al.
Immunotherapy treatment strategies have proven effective in a limited portion of patients, where identifying responders from non-responders to treatment remains a challenge. While some indications can be drawn from invasive biopsies, we nee...