Systematic review and meta-analysis of COVID-19 mRNA vaccine effectiveness against hospitalizations in adults [0.03%]
关于新冠mRNA疫苗对成人住院保护效果的系统综述和荟萃分析
Bill Kang-Fai Wong,Neil A Mabbott
Bill Kang-Fai Wong
Background: During the coronavirus disease 2019 (COVID-19) pandemic, Pfizer/BioNTech BNT162b2, and Moderna mRNA-1273 vaccines were central to the global pandemic control measures. ...
Hyperactivation of the PI3K pathway in inborn errors of immunity: current understanding and therapeutic perspectives [0.03%]
遗传性免疫缺陷中PI3K途径的过度活化：当前认识及治疗前景
Hanna IJspeert,Virgil A S H Dalm,Menno C van Zelm et al.
Hanna IJspeert et al.
The phosphoinositide-3-kinase (PI3K) pathway function is crucial to the normal development, differentiation, and function of immune cells including B, T, and NK cells. Following the description of two cohorts of patients with an inboirn err...
High-affinity T cell receptor ImmTAC® bispecific efficiently redirects T cells to kill tumor cells expressing the cancer-testis antigen PRAME [0.03%]
一种高效的T细胞受体双特异性抗体ImmTAC可以将T细胞重定向以杀伤高表达癌睾抗原PRAME的肿瘤细胞
Ana R Ribeiro,Camille Britton-Rivet,Laura Collins et al.
Ana R Ribeiro et al.
Background: PRAME (Preferentially expressed Antigen in Melanoma) is a cancer-testis antigen expressed in several tumor indications, representing an attractive anticancer target. However, its intracellular location limits ...
A rapid method to assess the in vivo multi-functionality of adoptively transferred engineered TCR T cells [0.03%]
一种快速评估转基因TCR-T细胞体内多功能性的方法
Anthony T Tan,Shou Kit Hang,Nicole Tan et al.
Anthony T Tan et al.
Introduction: The clinical efficacy of chimeric antigen and T cell receptor (TCR) T cell immunotherapies is attributed to their ability to proliferate and persist in vivo. Since the interaction of the engineered T cells w...
Advancements in nuclear imaging using radiolabeled nanobody tracers to support cancer immunotherapy [0.03%]
放射性标记纳米抗体示踪剂在核医学影像中的进展以支持癌症免疫治疗
Katty Zeven,Yoline Lauwers,Lynn De Mey et al.
Katty Zeven et al.
The evolving landscape of cancer immunotherapy has revolutionized cancer treatment. However, the dynamic tumor microenvironment has led to variable clinical outcomes, indicating a need for predictive biomarkers. Noninvasive nuclear imaging,...
Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells [0.03%]
CAR-T细胞中由TCR-T细胞中的共刺激受体调节的时空细胞因子产生机制丧失
Ashna Patel,Mikhail A Kutuzov,Michael L Dustin et al.
Ashna Patel et al.
CD8+ T cells contribute to immune responses by producing cytokines when their T-cell receptors (TCRs) recognise peptide antigens on major-histocompability-complex class I. However, excessive cytokine production can be harmful. For example, ...
Establishment of humanised xenograft models as in vivo study for lung metastasis of osteosarcoma [0.03%]
人源化异种移植模型的建立作为骨肉瘤肺转移的体内研究
Farhana Khamarudin,Mudiana Muhamad,Mohamad Johari Ibahim et al.
Farhana Khamarudin et al.
Humanised xenograft models and cancer cell lines are widely used for preclinical drug evaluation, biological studies, and targeted therapy strategies in cancer research. A humanised mouse model is a laboratory mouse that has been geneticall...
Tumour-reactive plasma cells in antitumour immunity: current insights and future prospects [0.03%]
肿瘤反应性浆细胞在抗肿瘤免疫中的作用：当前见解与未来前景
Peng Chen,Yiwei Chu,Ronghua Liu
Peng Chen
Tumour-reactive plasma cells (TRPCs) have been reported to be positively associated with the long-term survival of patients with various cancers. However, unlike tumour-specific antigen (TSA)-induced T cells which have precise effects again...
Dharanidharan Ramamurthy,Trishana Nundalall,Sanele Cingo et al.
Dharanidharan Ramamurthy et al.
Immunotherapies are disease management strategies that target or manipulate components of the immune system. Infectious diseases pose a significant threat to human health as evidenced by countries continuing to grapple with several emerging...
Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function [0.03%]
Janus激酶抑制剂改善STAT3功能增强型患者的临床症状
Shuya Kaneko,Fumiaki Sakura,Kay Tanita et al.
Shuya Kaneko et al.
Germline gain-of-function (GOF) variants in the signal transducer and activator of transcription 3 (STAT3) gene is an inborn error of immunity presenting with autoimmunity and lymphoproliferation. Symptoms can vary widely, and no effective ...