Doreen Lau,Tim Elliott
Doreen Lau
Introduction: Antigen processing and presentation are vital processes of the adaptive immunity. These processes involve a series of intracellular and extracellular events, including the enzymology within cells during anti...
Lung immune challenge study protocol: controlled exposure to inhaled resiquimod (R848) to study mechanisms of inflammation [0.03%]
肺免疫挑战研究方案：吸入给药供体来源的雷西莫德（R848）以研究炎症机制
Akhilesh Jha,Marie Fisk,Jamie Forrester et al.
Akhilesh Jha et al.
This study aims to develop a human lung immune challenge model using inhaled Resiquimod (R848), a Toll-like receptor 7/8 agonist, to investigate inflammatory mechanisms involved in the human respiratory mucosa in health and disease. This ap...
Bispecific T-cell engagers for the recruitment of T cells in solid tumors: a literature review [0.03%]
用于在实体肿瘤中募集T细胞的双特异性T细胞连接剂：文献回顾
Laura Dewaele,Ricardo A Fernandes
Laura Dewaele
In the past decade, T-cell-based immunotherapies have grown to become some of the most promising treatments for cancer. Following the success of immune checkpoint inhibitors, other T-cell-based therapies emerged including CAR-T cells and bi...
Delivery of IL-12 by neoantigen-reactive T cells promotes antitumor immunity in murine osteosarcoma mode [0.03%]
载有IL-12的neoantigen反应性T细胞促进小鼠骨肉瘤模型中的抗肿瘤免疫反应
Cong Tian,Xingxing Sun,Hongling Zhu et al.
Cong Tian et al.
Purpose: Despite the proven clinical benefits of cytokine therapy in cancer treatment, systemic administration of cytokines such as IL-12 is constrained by dose-limiting toxicities and short half-lives. To address these c...
Systematic review and meta-analysis of COVID-19 mRNA vaccine effectiveness against hospitalizations in adults [0.03%]
关于新冠mRNA疫苗对成人住院保护效果的系统综述和荟萃分析
Bill Kang-Fai Wong,Neil A Mabbott
Bill Kang-Fai Wong
Background: During the coronavirus disease 2019 (COVID-19) pandemic, Pfizer/BioNTech BNT162b2, and Moderna mRNA-1273 vaccines were central to the global pandemic control measures. ...
Hyperactivation of the PI3K pathway in inborn errors of immunity: current understanding and therapeutic perspectives [0.03%]
遗传性免疫缺陷中PI3K途径的过度活化：当前认识及治疗前景
Hanna IJspeert,Virgil A S H Dalm,Menno C van Zelm et al.
Hanna IJspeert et al.
The phosphoinositide-3-kinase (PI3K) pathway function is crucial to the normal development, differentiation, and function of immune cells including B, T, and NK cells. Following the description of two cohorts of patients with an inboirn err...
High-affinity T cell receptor ImmTAC® bispecific efficiently redirects T cells to kill tumor cells expressing the cancer-testis antigen PRAME [0.03%]
一种高效的T细胞受体双特异性抗体ImmTAC可以将T细胞重定向以杀伤高表达癌睾抗原PRAME的肿瘤细胞
Ana R Ribeiro,Camille Britton-Rivet,Laura Collins et al.
Ana R Ribeiro et al.
Background: PRAME (Preferentially expressed Antigen in Melanoma) is a cancer-testis antigen expressed in several tumor indications, representing an attractive anticancer target. However, its intracellular location limits ...
A rapid method to assess the in vivo multi-functionality of adoptively transferred engineered TCR T cells [0.03%]
一种快速评估转基因TCR-T细胞体内多功能性的方法
Anthony T Tan,Shou Kit Hang,Nicole Tan et al.
Anthony T Tan et al.
Introduction: The clinical efficacy of chimeric antigen and T cell receptor (TCR) T cell immunotherapies is attributed to their ability to proliferate and persist in vivo. Since the interaction of the engineered T cells w...
Advancements in nuclear imaging using radiolabeled nanobody tracers to support cancer immunotherapy [0.03%]
放射性标记纳米抗体示踪剂在核医学影像中的进展以支持癌症免疫治疗
Katty Zeven,Yoline Lauwers,Lynn De Mey et al.
Katty Zeven et al.
The evolving landscape of cancer immunotherapy has revolutionized cancer treatment. However, the dynamic tumor microenvironment has led to variable clinical outcomes, indicating a need for predictive biomarkers. Noninvasive nuclear imaging,...
Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells [0.03%]
CAR-T细胞中由TCR-T细胞中的共刺激受体调节的时空细胞因子产生机制丧失
Ashna Patel,Mikhail A Kutuzov,Michael L Dustin et al.
Ashna Patel et al.
CD8+ T cells contribute to immune responses by producing cytokines when their T-cell receptors (TCRs) recognise peptide antigens on major-histocompability-complex class I. However, excessive cytokine production can be harmful. For example, ...