Cytokine-induced memory-like NK cells combined with Tafasitamab demonstrate efficacy against B-cell acute lymphoblastic leukemia [0.03%]
细胞因子诱导的记忆样NK细胞联合Tafasitamab治疗B淋巴急淋白血病有效
Dimitrios Filioglou,Geovana S F Leite,Helena Batatinha et al.
Dimitrios Filioglou et al.
Cytokine-induced memory-like natural killer cells (CIMLNK) represent a novel form of adoptive cellular therapy that is easy to manufacture and readily available. These cells are generated after overnight stimulation of purified natural kill...
Knowledge-based immune-therapeutic advances for transplantation and cancer [0.03%]
基于知识的免疫治疗在移植和癌症中的进展
Elizabeth Simpson
Elizabeth Simpson
Increased knowledge about immune responses to what is perceived as 'foreign' or 'non-self' has revealed extraordinary levels of complexity. Research uncovering these has the potential to optimise immunotherapy. Remarkable progress has been ...
Tumor cell spheroid-induced suppression of primary human cytotoxic T cells as a scalable in vitro model of exhaustion [0.03%]
肿瘤细胞球体诱导初始人效应CTL耗竭的体内模型
Amal Alsubaiti,Hanin Alamir,Lan Huynh et al.
Amal Alsubaiti et al.
Background: Cytotoxic T lymphocytes (CTL) are key effectors in the antitumor immune response. However, their function is commonly suppressed in tumors in the form of exhausted CTL. Understanding mechanisms of suppression ...
Casper J Pachocki,Marianne Boes,Alsya J Affandi
Casper J Pachocki
Dendritic cells (DCs) are critical sentinels of the immune system, serving as indispensable bridges between innate and adaptive immune responses. DCs are a heterogeneous population, with subsets playing specialized roles in immune defense, ...
Regulatory B cells promote the immunosuppressive microenvironment and progression of clear cell renal cell carcinoma [0.03%]
调节性B细胞促进透明细胞肾细胞癌免疫抑制微环境和肿瘤进展
Qintao Ge,Siqi Zhou,Jiahe Lu et al.
Qintao Ge et al.
Background: Regulatory B cells (Bregs) are critical mediators of immune modulation and tumor progression. However, their prognostic relevance and mechanistic roles in clear cell renal cell carcinoma (ccRCC) remain insuffi...
GLUT5 armouring enhances adoptive T-cell therapy anti-tumour activity under glucose-limiting conditions [0.03%]
GLUT5包被增强适应性T细胞疗法在血糖限制条件下的抗肿瘤活性
Robert Page,Olivier Martinez,Daniel Larcombe-Young et al.
Robert Page et al.
Background: Cancer immunotherapy with engineered T cells has become a standard treatment for certain haematological cancers. However, clinical trial outcomes for solid tumours are significantly lagging. A primary challeng...
High level of anti-drug antibodies is associated with shorter survival in advanced solid cancer patients treated with Immune checkpoint inhibitors [0.03%]
高水平的抗药抗体与接受免疫检查点抑制剂治疗的晚期实体瘤患者的生存期缩短有关
Rui Zhao,Weihao Wang,Jingliang Wang et al.
Rui Zhao et al.
Background: Camrelizumab has become the first-line treatment for most patients with advanced tumors. Among advanced tumor patients undergoing camrelizumab, the majority develop immunogenicity, resulting in the production ...
Heterogeneity of regulatory B cells in autoimmune diseases: implications for immune equilibrium and therapeutic strategies [0.03%]
自身免疫性疾病中调控性B细胞的异质性：对免疫平衡及治疗策略的意义
Haozhen Yan,Jing He,Xiang Lin
Haozhen Yan
Regulatory B cells (Bregs) play a crucial role in maintaining immune tolerance and preventing autoimmune diseases. However, in autoimmune conditions, the quantity and function of Bregs are often impaired, leading to pro-inflammatory microen...
Cancer vaccine trial evaluations: immunobridging and potential immunological endpoints [0.03%]
癌症疫苗试验评估：免疫衔接和潜在的免疫学终点指标研究
Ahmed Hussain,Benjamin Moxley-Wyles,Michael Bryan et al.
Ahmed Hussain et al.
Therapeutic cancer vaccines are an emerging class of immunotherapy, but challenges remain in effectively adapting approved vaccines to a growing number of adjuvants, combination therapies, and antigen-selection methods. Phase III clinical t...
Insights from the bottom-up development of LGR5-targeting immunotherapeutics [0.03%]
基于自下而上策略开发LGR5靶向免疫治疗的见解
Nico Mueller,Marc Andrew de la Roche,Maike de la Roche
Nico Mueller
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a transcriptional target gene of the Wnt signalling pathway, is overexpressed in multiple cancers, including colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre...