CD40L and IL-4 suppress NK cell-mediated antibody-dependent cellular cytotoxicity through the HLA-E:NKG2A axis [0.03%]
CD40L和IL-4通过HLA-E:NKG2A轴抑制抗体依赖的自然杀伤细胞毒性作用
Lara V Graham,Ludmila Horehajova,Marco V Haselager et al.
Lara V Graham et al.
Background: Anti-CD20 antibodies are first-line treatments for B cell malignancies. Natural killer (NK) cells are important mediators of anti-CD20 antibody efficacy in humans through antibody-dependent cellular cytotoxici...
Correction to: Applying population mechanistic modelling to find determinants of chimeric antigen receptor T-cells dynamics in month-one lymphoma patients [0.03%]
Correction to：应用人群机理模型寻找一个月内淋巴瘤患者嵌合抗原受体T细胞动力学的决定因素
[This corrects the article DOI: 10.1093/immadv/ltaf001.]. © The Author(s) 2025. Published by Oxford University Press on behalf of the British Society fo...
Published Erratum
Immunotherapy advances. 2025 Sep 10;5(1):ltaf028. DOI:10.1093/immadv/ltaf028 2025
Applying population mechanistic modelling to find determinants of chimeric antigen receptor T-cells dynamics in month-one lymphoma patients [0.03%]
应用人群机制模型寻找月内淋巴瘤患者嵌合抗原受体T细胞动力学的决定因素
Liam V Brown,Mark McConnell,Robert Rosler et al.
Liam V Brown et al.
Background: Chimeric antigen receptor (CAR) T-cells have been utilized for the treatment of several malignancies, including Non-Hodgkin lymphomas. A myriad of product- and patient-specific factors determines the extent of...
SMAC mimetics induce human macrophages to phagocytose live cancer cells [0.03%]
SMAC模拟物诱导人类巨噬细胞吞噬活癌细胞
Samantha Y Liu,Max P M Hulsman,Philipp Leyendecker et al.
Samantha Y Liu et al.
Macrophages engulf apoptotic bodies and cellular debris as part of homeostasis, but they can also phagocytose live cells, such as aged red blood cells. Pharmacologic reprogramming with the SMAC mimetic LCL161 in combination with T-cell-deri...
Targeting of acute myeloid leukemia by five-gene engineered T cells expressing transgenic T-cell receptor specific to WT1, chimeric antigenic receptor specific to GM-CSF receptor, bispecific T-cell engager specific to CD33, and tEGFR suicide gene system [0.03%]
靶向急性髓系白血病的五基因工程T细胞：表达WT1特异性转基因T细胞受体、GM-CSF受体特异性嵌合抗原受体及CD33特异性双特异性T细胞衔接器和tEGFR自杀基因系统
Kristýna Šmilauerová,Martin Štach,Martin Mucha et al.
Kristýna Šmilauerová et al.
Background: Cancer immunotherapy with transgenic T-cell receptor-engineered T cells (TCR-T) enables the targeting of intracellular tumor-specific antigens; in contrast, chimeric antigen receptor-modified T cells (CAR-T) m...
Katie Coates,Robert J Nibbs,Alasdair R Fraser
Katie Coates
Glioblastoma (GBM) is a devastating malignant disease with a remarkably low 5-year survival rate and invariably poor prognosis. Current conventional treatment options (surgery, targeted radiotherapy, and a limited number of chemotherapies) ...
Cytokine-induced memory-like NK cells combined with Tafasitamab demonstrate efficacy against B-cell acute lymphoblastic leukemia [0.03%]
细胞因子诱导的记忆样NK细胞联合Tafasitamab治疗B淋巴急淋白血病有效
Dimitrios Filioglou,Geovana S F Leite,Helena Batatinha et al.
Dimitrios Filioglou et al.
Cytokine-induced memory-like natural killer cells (CIMLNK) represent a novel form of adoptive cellular therapy that is easy to manufacture and readily available. These cells are generated after overnight stimulation of purified natural kill...
Knowledge-based immune-therapeutic advances for transplantation and cancer [0.03%]
基于知识的免疫治疗在移植和癌症中的进展
Elizabeth Simpson
Elizabeth Simpson
Increased knowledge about immune responses to what is perceived as 'foreign' or 'non-self' has revealed extraordinary levels of complexity. Research uncovering these has the potential to optimise immunotherapy. Remarkable progress has been ...
Tumor cell spheroid-induced suppression of primary human cytotoxic T cells as a scalable in vitro model of exhaustion [0.03%]
肿瘤细胞球体诱导初始人效应CTL耗竭的体内模型
Amal Alsubaiti,Hanin Alamir,Lan Huynh et al.
Amal Alsubaiti et al.
Background: Cytotoxic T lymphocytes (CTL) are key effectors in the antitumor immune response. However, their function is commonly suppressed in tumors in the form of exhausted CTL. Understanding mechanisms of suppression ...
Casper J Pachocki,Marianne Boes,Alsya J Affandi
Casper J Pachocki
Dendritic cells (DCs) are critical sentinels of the immune system, serving as indispensable bridges between innate and adaptive immune responses. DCs are a heterogeneous population, with subsets playing specialized roles in immune defense, ...