Plasma exchange for severe immune-related adverse events from checkpoint inhibitors: an early window of opportunity? [0.03%]
重症免疫检查点抑制剂相关毒性反应的血浆置换治疗：一个早期的时间窗口吗？
Tamiko R Katsumoto,Kalin L Wilson,Vinay K Giri et al.
Tamiko R Katsumoto et al.
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of several advanced malignancies leading to durable remission in a subset of patients. Their rapidly expanding use has led to an increased frequency of immune-related adv...
Corrigendum to: 100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes [0.03%]
胰岛素发现一百年后：免疫疗法将成为1型糖尿病的下一个研究前沿（勘误）
[This corrects the article DOI: 10.1093/immadv/ltab024.]. © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society fo...
Published Erratum
Immunotherapy advances. 2022 Jun 22;2(1):ltac013. DOI:10.1093/immadv/ltac013 2022
New and emerging concepts and therapies for the treatment of food allergy [0.03%]
新型和新兴的食品过敏治疗方法概念及疗法
David W Hwang,Cathryn R Nagler,Christina E Ciaccio
David W Hwang
Food allergy is an increasingly common disease that often starts in early childhood and lasts throughout life. Self-reported food allergy has risen at a rate of 1.2% per decade since 1988, and by 2018, the prevalence of food allergy in the ...
Seven mysteries of LAG-3: a multi-faceted immune receptor of increasing complexity [0.03%]
LAG-3的七大谜团：一个复杂性不断增加的多功能免疫受体
Stephanie E A Burnell,Lorenzo Capitani,Bruce J MacLachlan et al.
Stephanie E A Burnell et al.
Despite three decades of research to its name and increasing interest in immunotherapies that target it, LAG-3 remains an elusive co-inhibitory receptor in comparison to the well-established PD-1 and CTLA-4. As such, LAG-3 targeting therapi...
100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes [0.03%]
胰岛素问世百年后的今天：免疫治疗将成为1型糖尿病的下一个制高点吗？
James A Pearson,Eoin F McKinney,Lucy S K Walker
James A Pearson
Type 1 diabetes (T1D) is an autoimmune disease characterised by T cell-mediated destruction of the insulin-producing β cells in the pancreas. Similar to other autoimmune diseases, the incidence of T1D is increasing globally. The discovery ...
A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes [0.03%]
乌司奴单抗治疗1型糖尿病的2期临床试验
Ashish K Marwaha,Samuel Chow,Anne M Pesenacker et al.
Ashish K Marwaha et al.
Objectives: We assessed the safety of ustekinumab (a monoclonal antibody used in psoriasis to target the IL-12 and IL-23 pathways) in a small cohort of recent-onset (
Sophie Curio,Gustav Jonsson,Sonja Marinović
Sophie Curio
Cancer immunotherapies have significantly improved patient survival and treatment options in recent years. Nonetheless, the success of immunotherapy is limited to certain cancer types and specific subgroups of patients, making the developme...
The clinical correlates of vaccine-induced immune thrombotic thrombocytopenia after immunisation with adenovirus vector-based SARS-CoV-2 vaccines [0.03%]
腺病毒载体新冠疫苗接种后出现的疫苗诱发免疫性血小板减少症的临床特点
Eleanor R Gaunt,Neil A Mabbott
Eleanor R Gaunt
We are at a critical stage in the COVID-19 pandemic where vaccinations are being rolled out globally, in a race against time to get ahead of the SARS-CoV-2 coronavirus and the emergence of more highly transmissible variants. A range of vacc...
Association between incidental statin use and skeletal myopathies in patients treated with immune checkpoint inhibitors [0.03%]
接受免疫检查点抑制剂治疗的患者中他汀类药物非预期使用与骨骼肌病之间的关联
Zsofia D Drobni,Sean P Murphy,Raza M Alvi et al.
Zsofia D Drobni et al.
Objectives: Skeletal myopathies are highly morbid, and in rare cases even fatal, immune-related adverse events (irAE) associated with immune checkpoint inhibitors (ICI). Skeletal myopathies are also a recognized statin-as...
A glutamine 'tug-of-war': targets to manipulate glutamine metabolism for cancer immunotherapy [0.03%]
谷氨酰胺“拉锯战”：操控谷氨酰胺代谢以用于癌症免疫治疗的目标
Laura J Pallett,Sarah Dimeloe,Linda V Sinclair et al.
Laura J Pallett et al.
Within the tumour microenvironment (TME), there is a cellular 'tug-of-war' for glutamine, the most abundant amino acid in the body. This competition is most evident when considering the balance between a successful anti-tumour immune respon...