DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease [0.03%]
DNAM1和TIGIT平衡T细胞反应，特应性皮炎患者T细胞中低TIGIT表达对应炎症反应
Marleen E Jacobs,Juliëtte N Pouw,Michel A Olde Nordkamp et al.
Marleen E Jacobs et al.
Objectives: Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can interact with the stimulatory receptor DNAM1 or inhibitory receptor T...
The MARVEL trial: a phase 2b randomised placebo-controlled trial of oral MitoQ in moderate ulcerative colitis [0.03%]
MARVEL试验：MitoQ口服治疗中度溃疡性结肠炎的2b期随机双盲安慰剂对照试验
Emily Gwyer Findlay,Greg Sutton,Gwo-Tzer Ho
Emily Gwyer Findlay
Ulcerative colitis (UC) is an inflammatory disease of the large bowel which is characterised by dysregulated immunity and death to epithelial cells in the bowel, leading to prolonged inflammation. This can ultimately lead to surgery to remo...
Beyond Ipilimumab: a review of immunotherapeutic approaches in clinical trials in melanoma [0.03%]
伊匹单抗之外：黑色素瘤临床试验中的免疫治疗综述
Gary Middleton
Gary Middleton
In this first in a series of 'Trials Watch' articles, we briefly review a highly selected set of clinical trials that are currently recruiting or about to open to recruitment in melanoma, the disease first transformed by the introduction of...
Tim Elliott
Tim Elliott
CAR-T cells leave the comfort zone: current and future applications beyond cancer [0.03%]
CAR-T细胞走出舒适区：当前及未来抗癌以外的前景与挑战
Mariana Torres Mazzi,Karina Lôbo Hajdu,Priscila Rafaela Ribeiro et al.
Mariana Torres Mazzi et al.
Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough in the immunotherapy field and has achieved great success following its approval in 2017 for the treatment of B cell malignancies. While CAR-T cells are mostly applied...
Adrenergic signaling regulation of macrophage function: do we understand it yet? [0.03%]
肾上腺素信号调节巨噬细胞功能：我们了解清楚了吗？
Beatriz Marton Freire,Filipe Menegatti de Melo,Alexandre S Basso
Beatriz Marton Freire
Macrophages are immune cells that are widespread throughout the body and critical for maintaining tissue homeostasis. Their remarkable plasticity allows them to acquire different phenotypes, becoming able either to fight infection (M1-like,...
Current and future perspectives of chimeric antigen receptors against glioblastoma [0.03%]
嵌合抗原受体治疗胶质母细胞瘤的现状与未来展望
Josephine Zhang,Jesús A Siller-Farfán
Josephine Zhang
Glioblastoma multiforme (GBM) is the most malignant form of cancer in the central nervous system; even with treatment, it has a 5-year survival rate of 7.2%. The adoptive cell transfer (ACT) of T cells expressing chimeric antigen receptors ...
Targeting the high affinity receptor, FcγRI, in autoimmune disease, neuropathy, and cancer [0.03%]
靶向自身免疫病、神经病变和癌症中的高亲和力受体FcγRI
Tosca Holtrop,Kevin Budding,Arianne M Brandsma et al.
Tosca Holtrop et al.
The Fc gamma receptor I (FcγRI or CD64) is the only human Fc receptor with a high affinity for monomeric IgG. It plays a crucial role in immunity, as it mediates cellular effector functions of antibodies including phagocytosis, antigen pre...
Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration [0.03%]
口服抗原可通过给药时间的不同来减少或加剧炎性关节病动物模型的病理变化
Gavin R Meehan,Hannah E Scales,Iain B McInnes et al.
Gavin R Meehan et al.
Currently, treatments for rheumatoid arthritis (RA) are focussed on management of disease symptoms rather than addressing the cause of disease, which could lead to remission and cure. Central to disease development is the induction of autoi...
Prevalence of inverse psoriasis subtype with immune checkpoint inhibitors [0.03%]
免疫检查点抑制剂诱导的逆向银屑病亚型的流行率
Abdulhadi Jfri,Bonnie Leung,Jordan T Said et al.
Abdulhadi Jfri et al.
Background: Cutaneous immune-related adverse events (irAEs) are the most common irAEs caused by immune-checkpoint inhibitors (ICI). Psoriasiform eruptions, both de novo and flares, may occur. Evidence is lacking on invers...