Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium [0.03%]
Klebsiella肺炎克雷伯菌流行病学和生物学的全球视角：KLEBS 2024研讨会报告
Chiara Crestani,Kelly L Wyres,Jabir Abdulahi et al.
Chiara Crestani et al.
The inaugural Klebsiella Epidemiology and Biology Symposium (KLEBS) took place in November 20-22, 2024, at the Institut Pasteur in Paris. It covered a broad multidisciplinary range of topics from fundamental biology to public health aspects...
Biofilm removal in hospital sink drains drives unintended surges in antibiotic resistance [0.03%]
医院水槽排水管中的生物膜去除会导致意外的抗生素耐药性增强
Shireen M Kotay,Hardik I Parikh,Hyun S Gweon et al.
Shireen M Kotay et al.
The prevalence and proliferation of antimicrobial-resistant bacteria is considered one of the critical issues of our time. Wastewater is a habitat for complex microbial communities where bacteria share antimicrobial-resistance genes through...
Enhancing infection diagnostics in advanced chronic liver disease: harnessing clinical metagenomics for rapid pathogen and antimicrobial resistance detection [0.03%]
利用临床元基因组学加速病原体和抗菌药物耐药性检测以提高慢性肝病感染诊断的精准度
Merianne Mohamad,Chrysi Sergaki,Vishal C Patel
Merianne Mohamad
Patients with advanced chronic liver disease who have underlying cirrhosis are highly susceptible to bacterial infections, which significantly increase the risk of complications and mortality, compounded by escalating antimicrobial resistan...
Antimicrobial resistance databases: opportunities and challenges for public health [0.03%]
抗菌药物耐药数据库：公共卫生中的机遇与挑战
Chad M Centner,Sabrina Di Gregorio,Silvia Argimón et al.
Chad M Centner et al.
Antimicrobial resistance (AMR) databases enable the identification of AMR determinants from pathogen sequence data and the prediction of resistance profiles, enhancing AMR surveillance and informing a range of public health interventions. T...
Consequences of benzalkonium chloride tolerance for selection dynamics and de novo resistance evolution driven by antibiotics [0.03%]
苯扎氯铵耐药性对抗生素驱动的选择动力学和全新耐药性进化的影响
Orestis Kanaris,Lydia-Yasmin Sobisch,Annett Gödt et al.
Orestis Kanaris et al.
Biocides are used in large amounts in industrial, medical, and domestic settings. Benzalkonium chloride (BAC) is a commonly used biocide, for which previous research revealed that Escherichia coli can rapidly adapt to tolerate BAC-disinfect...
Microbiotoxicity: an under-recognised player in drug efficacy, toxicity, and health outcomes [0.03%]
药物疗效、毒性和健康结果中的微生物毒性：一个被忽视的因素
Shirley Do Nascimento,Anastasia A Theodosiou,Chrysi Sergaki
Shirley Do Nascimento
The gut microbiome regulates immunity, inflammation, and metabolism. Disruption by antibiotic and non-antibiotic drugs, termed microbiotoxicity, may impair efficacy of treatments, including cancer immunotherapy and vaccination, and contribu...
Metabolomics-driven prediction of antibiotic resistance: a perspective on pre-genetic intervention [0.03%]
基于代谢组学的抗生素耐药性预测研究——遗传干预前的视角分析
Maytham Hussein,Darren J Creek,Mark Baker et al.
Maytham Hussein et al.
Antibiotic resistance is surging, demanding approaches that detect resistance before genetic fixation, since MIC, sequencing, and culture assays detect resistance late. We present Metabolomics-Driven Intervention Antibiotic Design (MDAD), w...
Emerging antifungal resistance in Candida parapsilosis: the end of the innocence [0.03%]
新型抗真菌药物耐药性的产生标志着对产白念珠菌的治疗已经进入了一个新时代
Jesús Guinea,Pilar Escribano,Manon Cadeau et al.
Jesús Guinea et al.
Candida parapsilosis is an opportunistic yeast that was recently deemed a high- importance fungal pathogen by the World Health Organization. In fact, C. parapsilosis poses an escalating threat in healthcare settings due to its ability to ad...
Gene-specific reversal of carbapenem-resistant pseudomonas aeruginosa via phage-delivered CRISPR-Cas13a [0.03%]
利用噬菌体递送CRISPR-Cas13a逆转泛耐药绿脓杆菌的耐药基因
Tomofumi Kawaguchi,Shinya Watanabe,Yi Liu et al.
Tomofumi Kawaguchi et al.
Metallo-β-lactamases (MBLs), such as those encoded by blaIMP-1, confer resistance to carbapenem antibiotics and represent a critical challenge in treating infections caused by multidrug-resistant Pseudomonas aeruginosa. Here, we report a p...
Gene copy-number features generalize better than SNPs for antimicrobial resistance prediction in Staphylococcus aureus [0.03%]
金黄色葡萄球菌耐药基因拷贝数特征比SNP具有更好的泛化能力用于抗菌药物的耐药性预测
Bruna F Fistarol,Joao D Gervasio,Gergely J Szöllősi
Bruna F Fistarol
Rapid prediction of antimicrobial resistance (AMR) from genome sequences is essential for timely therapy, yet models based on curated marker panels or core-genome Single Nucleotide Polymorphisms (SNPs) often fail to generalize to novel bact...