Emerging antifungal resistance in Candida parapsilosis: the end of the innocence [0.03%]
新型抗真菌药物耐药性的产生标志着对产白念珠菌的治疗已经进入了一个新时代
Jesús Guinea,Pilar Escribano,Manon Cadeau et al.
Jesús Guinea et al.
Candida parapsilosis is an opportunistic yeast that was recently deemed a high- importance fungal pathogen by the World Health Organization. In fact, C. parapsilosis poses an escalating threat in healthcare settings due to its ability to ad...
Gene-specific reversal of carbapenem-resistant pseudomonas aeruginosa via phage-delivered CRISPR-Cas13a [0.03%]
利用噬菌体递送CRISPR-Cas13a逆转泛耐药绿脓杆菌的耐药基因
Tomofumi Kawaguchi,Shinya Watanabe,Yi Liu et al.
Tomofumi Kawaguchi et al.
Metallo-β-lactamases (MBLs), such as those encoded by blaIMP-1, confer resistance to carbapenem antibiotics and represent a critical challenge in treating infections caused by multidrug-resistant Pseudomonas aeruginosa. Here, we report a p...
Gene copy-number features generalize better than SNPs for antimicrobial resistance prediction in Staphylococcus aureus [0.03%]
金黄色葡萄球菌耐药基因拷贝数特征比SNP具有更好的泛化能力用于抗菌药物的耐药性预测
Bruna F Fistarol,Joao D Gervasio,Gergely J Szöllősi
Bruna F Fistarol
Rapid prediction of antimicrobial resistance (AMR) from genome sequences is essential for timely therapy, yet models based on curated marker panels or core-genome Single Nucleotide Polymorphisms (SNPs) often fail to generalize to novel bact...
Evolution of proteolysis-targeting chimeras (PROTAC) technology to overcome challenges of antimicrobial resistance [0.03%]
PROTAC技术的演变及其在克服抗菌素耐药性挑战方面的应用
Dhanashree N Sarwan,Pramod B Khedekar,Ritesh P Bhole et al.
Dhanashree N Sarwan et al.
Targeted protein degradation (TPD) is an innovative therapeutic approach that bypasses traditional drug inhibition methods. Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that harness degradation machinery to remove tar...
Longitudinal replicated metagenomic analysis of biosolids-amended soils reveals enrichment of ARGs, virulence factors, and ESKAPE pathogens [0.03%]
纵向重复元基因组分析：污泥改良土壤中ARGs、毒力因子和ESKAPE致病菌的富集
John Ste Marie,Catherine Mays,Bing Guo et al.
John Ste Marie et al.
Biosolids land application introduces antibiotic resistance genes (ARGs) and clinically relevant pathogens into agricultural soils, raising concerns about long-term environmental and public health impacts. Despite growing interest in biosol...
Host genetics regulate bacterial plasmid conjugation differentially in avian ceca explant co-culture through secretory miRNA [0.03%]
宿主基因通过分泌型miRNA在禽盲肠外植体共培养中调节细菌质粒的接合转移作用不同
Caleb Skow,Logan C Ott,Susan J Lamont et al.
Caleb Skow et al.
The rapid emergence of multidrug-resistant virulent bacteria poses a global health concern. It is enabled through the lateral transfer of plasmid-carrying antibiotic resistance and virulence genes between bacteria. The guts of animals, part...
Microbial interactions as the key to understanding and controlling environmental spread of antibiotic resistance genes [0.03%]
微生物互作是理解及控制环境中的抗性基因传播的关键因素
Haining Huang,Litao Wei,Ling Li et al.
Haining Huang et al.
Beyond abiotic factors, microbial interactions are critical yet understudied regulators of environmental antibiotic resistance gene (ARG) spread, whose neglect hinders control efforts. We synthesize their dual roles in ARG dissemination and...
Aula Abbara,Alaa Almansour,Reem Hasan Obaydo et al.
Aula Abbara et al.
Protracted conflict has exacerbated existing drivers of antimicrobial resistance in Syria and introduced new ones; these drivers intersect, leading to a rising threat across Syria’s health system, where untreatable infections are rife. To ...
Molecular insights into silver nanoparticle resistance in Acinetobacter baumannii and unique adaptations to ionic silver [0.03%]
分子层面的鲍曼不动杆菌对抗银纳米粒子及独特的一类银离子适应性反应的新见解
Oliver McNeilly,Daniel G Mediati,Matthew J Pittorino et al.
Oliver McNeilly et al.
This research provides molecular insights into the evolutionarily adapted defense mechanisms of a bacterial pathogen against the complex antimicrobial activity of silver nanoparticles at the transcriptional level. The Gram-negative, biofilm...
Next generation ESKAPE-E superbugs: identifying transmissible locus of stress tolerance and antibiotic resistance in pandemic bacterial lineages [0.03%]
下一代ESKAPE-E超级细菌：在大流行菌株中识别压力耐受性和抗生素抗性的可传播位点
Dmitriy Li,Veronica M Jarocki,Ethan R Wyrsch et al.
Dmitriy Li et al.
The transmissible locus of stress tolerance (tLST) confers enhanced resilience to stressors, including chlorine-based disinfectants and heat. A systematic examination of 48,183 complete bacterial genomes representing 7,190 unique species id...