Survival of ampicillin-treated uropathogenic Escherichia coli is independent of single-cell growth rates [0.03%]
氨苄青霉素处理的尿路致病性大肠杆菌的存活与单个细胞生长速率无关
Yoshiko Miyahara,François Signorino-Gelo,Nicolas Elian Michel Lonchampt et al.
Yoshiko Miyahara et al.
The refractoriness of persistent infections to antibiotics necessitates lengthy treatment regimens to prevent therapeutic failures and relapses. Persistence has been attributed to entry of a small fraction of bacterial cells into a slowly g...
A conjugal gene drive-like system efficiently suppresses antibiotic resistance in a bacterial population [0.03%]
一种类似嫁接基因驱动的系统可有效抑制细菌种群的抗生素抗性
Saluja Kaduwal,Elizabeth C Stuart,Ankush Auradkar et al.
Saluja Kaduwal et al.
Antibiotic resistance (AR) is an escalating public health threat, necessitating innovative strategies to control resistant bacterial populations. One promising approach involves engineering genetic elements that can spread within microbial ...
Food safety culture and the control of microbial communities in food production environments [0.03%]
食品安全文化及食品生产环境中微生物群的控制
Oleksii Omelchenko,Maria Diaz,Ana Victoria Gutiérrez et al.
Oleksii Omelchenko et al.
Food safety risks are controlled in agrifood settings by reducing the microbial burden in food ingredients and food production environments. Hygiene programmes involve an incremental implementation of chemical treatments (e.g., disinfectant...
Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium [0.03%]
Klebsiella肺炎克雷伯菌流行病学和生物学的全球视角：KLEBS 2024研讨会报告
Chiara Crestani,Kelly L Wyres,Jabir Abdulahi et al.
Chiara Crestani et al.
The inaugural Klebsiella Epidemiology and Biology Symposium (KLEBS) took place in November 20-22, 2024, at the Institut Pasteur in Paris. It covered a broad multidisciplinary range of topics from fundamental biology to public health aspects...
Biofilm removal in hospital sink drains drives unintended surges in antibiotic resistance [0.03%]
医院水槽排水管中的生物膜去除会导致意外的抗生素耐药性增强
Shireen M Kotay,Hardik I Parikh,Hyun S Gweon et al.
Shireen M Kotay et al.
The prevalence and proliferation of antimicrobial-resistant bacteria is considered one of the critical issues of our time. Wastewater is a habitat for complex microbial communities where bacteria share antimicrobial-resistance genes through...
Enhancing infection diagnostics in advanced chronic liver disease: harnessing clinical metagenomics for rapid pathogen and antimicrobial resistance detection [0.03%]
利用临床元基因组学加速病原体和抗菌药物耐药性检测以提高慢性肝病感染诊断的精准度
Merianne Mohamad,Chrysi Sergaki,Vishal C Patel
Merianne Mohamad
Patients with advanced chronic liver disease who have underlying cirrhosis are highly susceptible to bacterial infections, which significantly increase the risk of complications and mortality, compounded by escalating antimicrobial resistan...
Antimicrobial resistance databases: opportunities and challenges for public health [0.03%]
抗菌药物耐药数据库：公共卫生中的机遇与挑战
Chad M Centner,Sabrina Di Gregorio,Silvia Argimón et al.
Chad M Centner et al.
Antimicrobial resistance (AMR) databases enable the identification of AMR determinants from pathogen sequence data and the prediction of resistance profiles, enhancing AMR surveillance and informing a range of public health interventions. T...
Consequences of benzalkonium chloride tolerance for selection dynamics and de novo resistance evolution driven by antibiotics [0.03%]
苯扎氯铵耐药性对抗生素驱动的选择动力学和全新耐药性进化的影响
Orestis Kanaris,Lydia-Yasmin Sobisch,Annett Gödt et al.
Orestis Kanaris et al.
Biocides are used in large amounts in industrial, medical, and domestic settings. Benzalkonium chloride (BAC) is a commonly used biocide, for which previous research revealed that Escherichia coli can rapidly adapt to tolerate BAC-disinfect...
Microbiotoxicity: an under-recognised player in drug efficacy, toxicity, and health outcomes [0.03%]
药物疗效、毒性和健康结果中的微生物毒性：一个被忽视的因素
Shirley Do Nascimento,Anastasia A Theodosiou,Chrysi Sergaki
Shirley Do Nascimento
The gut microbiome regulates immunity, inflammation, and metabolism. Disruption by antibiotic and non-antibiotic drugs, termed microbiotoxicity, may impair efficacy of treatments, including cancer immunotherapy and vaccination, and contribu...
Metabolomics-driven prediction of antibiotic resistance: a perspective on pre-genetic intervention [0.03%]
基于代谢组学的抗生素耐药性预测研究——遗传干预前的视角分析
Maytham Hussein,Darren J Creek,Mark Baker et al.
Maytham Hussein et al.
Antibiotic resistance is surging, demanding approaches that detect resistance before genetic fixation, since MIC, sequencing, and culture assays detect resistance late. We present Metabolomics-Driven Intervention Antibiotic Design (MDAD), w...