Changes in antimicrobial resistance profiles of Escherichia coli and the metagenome on Dutch pig farms after antimicrobial usage interventions [0.03%]
减少抗菌药物使用对荷兰养猪场大肠杆菌耐药性及微生物群落的影响分析
R E C Luiken,H Prinsen,S N Dasari et al.
R E C Luiken et al.
The use of antimicrobials in livestock farming drives selection and dissemination of antimicrobial resistance (AMR), prompting implementation of veterinary stewardship programs to reduce antimicrobial usage (AMU). We evaluated changes in AM...
Distinct infant resistome trajectories shaped by country income and geography revealed through global metagenomics reanalysis [0.03%]
基于全球元基因组重测序的收入水平和地理因素塑造的独特婴儿抗菌素耐药基因群动态轨迹
Charlie C Luchen,Gonçalo J Piedade,Mwelwa Chibuye et al.
Charlie C Luchen et al.
Antimicrobial resistance (AMR) costs lives, diminishes antimicrobial effectiveness and increases health care costs. We conducted a re-analysis of pooled fecal metagenomes from individual participants to characterise AMR gene (ARG) distribut...
Mechanistic insights into plasmid transfer inhibition in Enterobacterales by nucleoside analogues [0.03%]
核苷类似物抑制肠杆菌目质粒转移的机制研究
Ilyas Alav,Ayesha Ashraf,Parisa Pordelkhaki et al.
Ilyas Alav et al.
Antimicrobial resistance (AMR) poses a major global health threat, with carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales causing widespread infections and deaths. Much of this resistance spreads thro...
Selection of porin and LPS mutants during infection by phage T4 facilitates the emergence of β-lactam resistance in Escherichia coli [0.03%]
侵袭性噬菌体T4选择的大肠杆菌porin和LPS突变体促进β-内酰胺耐药的产生
Justine Le-Boulch,Erika Charneau,Anne Chevallereau et al.
Justine Le-Boulch et al.
Understanding all sources of selective pressure that contribute to the emergence of antibiotic resistance is essential for developing sustainable antimicrobial strategies. Here, we investigated the interaction between phage T4 and Escherich...
Bacterial cell fate under stress: lipid remodeling and antimicrobial peptide attack [0.03%]
压力下细菌细胞的命运：脂质重塑和抗菌肽攻击
Djenana Vejzovic,Theresa Schwaiger,Altea Topciu et al.
Djenana Vejzovic et al.
Dynamic changes in lipid membrane composition are a common response to stress, often involving shifts in key lipid molecules. Phosphatidic acid (PA), a central precursor in lipid biosynthesis, accumulates when anionic phospholipid synthesis...
Artificial intelligence for early detection and risk prediction of antimicrobial resistance in aquatic ecosystems [0.03%]
人工智能在水生生态系统中抗菌药物耐药的早期检测和风险预测中的作用
William Calero-Cáceres,Ronan Adler Tavella,Fábio Parra Sellera et al.
William Calero-Cáceres et al.
Aquatic environments are key reservoirs and dissemination pathways of antimicrobial resistance (AMR). However, current water-based surveillance remains fragmented and inefficient for the timely detection of emerging threats. Integrating art...
Fate of the resistance profile of drinking water biofilm exposed to a sub-minimum inhibitory concentration of ciprofloxacin [0.03%]
暴露于环丙沙星亚抑菌浓度下的饮用水生物膜耐药性命运研究
Victoria Rilstone,Yves Filion,Pascale Champagne
Victoria Rilstone
Early research has found that biofilms adhered to treatment filtration beds and the inside of drinking water pipes help promote antimicrobial resistance (AMR) in drinking water systems. This study investigates the impact of a sub-minimum in...
Genomic survey uncovers the emergence of a multidrug-resistant dominant lineage in Proteus mirabilis populations [0.03%]
基因组测序揭示多药耐药优势谱系在阴沟肠杆菌种群中的出现
Tiejun Zhang,Hongcheng Wei,Zijing Ju et al.
Tiejun Zhang et al.
Proteus mirabilis, a Gram-negative bacterium renowned for its distinctive swarming motility, is a major causative agent of catheter-associated urinary tract infections (CAUTIs) and nosocomial complications. While advances in sequencing tech...
Development of the antimicrobial resistance burden score through a modified eDelphi [0.03%]
改良eDelphi法制定抗菌药物耐药负担评分
William J Waldock,Mark Gilchrist,Frances Davies et al.
William J Waldock et al.
Current antimicrobial resistance (AMR) surveillance relies on fragmented indicators that fail to capture institutional AMR burden complexity. To develop the AMR Burden Score, a three-round modified eDelphi study engaged interdisciplinary ex...
Enhancing quality of antimicrobial prescribing through 'Ask Eolas' (language model): a user-testing and simulation evaluation [0.03%]
通过"Aisk Eolas"(语言模型)提高抗菌药物处方质量：用户测试和模拟评估
William J Waldock,Mark Gilchrist,Hutan Ashrafian et al.
William J Waldock et al.
We aimed to assess prescribing accuracy, error reduction, usability, and clinician confidence of Ask Eolas (a retrieval-augmented generation-enhanced AI-CDSS) compared to existing antimicrobial guidance tools. We conducted a structured simu...