Genomic survey uncovers the emergence of a multidrug-resistant dominant lineage in Proteus mirabilis populations [0.03%]
基因组测序揭示多药耐药优势谱系在阴沟肠杆菌种群中的出现
Tiejun Zhang,Hongcheng Wei,Zijing Ju et al.
Tiejun Zhang et al.
Proteus mirabilis, a Gram-negative bacterium renowned for its distinctive swarming motility, is a major causative agent of catheter-associated urinary tract infections (CAUTIs) and nosocomial complications. While advances in sequencing tech...
Development of the antimicrobial resistance burden score through a modified eDelphi [0.03%]
改良eDelphi法制定抗菌药物耐药负担评分
William J Waldock,Mark Gilchrist,Frances Davies et al.
William J Waldock et al.
Current antimicrobial resistance (AMR) surveillance relies on fragmented indicators that fail to capture institutional AMR burden complexity. To develop the AMR Burden Score, a three-round modified eDelphi study engaged interdisciplinary ex...
Enhancing quality of antimicrobial prescribing through 'Ask Eolas' (language model): a user-testing and simulation evaluation [0.03%]
通过"Aisk Eolas"(语言模型)提高抗菌药物处方质量：用户测试和模拟评估
William J Waldock,Mark Gilchrist,Hutan Ashrafian et al.
William J Waldock et al.
We aimed to assess prescribing accuracy, error reduction, usability, and clinician confidence of Ask Eolas (a retrieval-augmented generation-enhanced AI-CDSS) compared to existing antimicrobial guidance tools. We conducted a structured simu...
Novel continuous experimental evolution methodology uncovers rapid resistance development and cross-resistance [0.03%]
新颖的连续实验进化方法发现快速抗性发展和交叉抗性
Thaddäus Echelmeyer,Markus Ellmann,Stefan E Heiden et al.
Thaddäus Echelmeyer et al.
Antimicrobial resistance poses a significant global health threat. Experimental evolution studies are crucial in understanding resistance mechanisms and thereby informing strategies to preserve antibiotic efficacy. We developed a novel cont...
Five-decade global expansion of Staphylococcus argenteus ST2250 shapes antimicrobial resistance dynamics [0.03%]
半个世纪以来的金黄色葡萄球菌ST2250全球扩张及其对抗微生物药物动态的影响
Letícia Roberta Martins Costa,Maitiú Marmion,Ana Beatriz Garcez Buiatte et al.
Letícia Roberta Martins Costa et al.
Staphylococcus argenteus is implicated in various superficial and invasive diseases in humans, and multidrug resistance has been increasingly reported. Here, we aim to elucidate the bacterial features shaping the global spread of antimicrob...
Phage-meropenem synergy against OXA-48-producing Klebsiella pneumoniae clinical isolates [0.03%]
噬菌体-美罗培南联合疗法对抗产OXA-48型肺炎克雷伯菌临床分离株
Irene Cantallops,Celia Ferriol-González,Tamara Barcos-Rodríguez et al.
Irene Cantallops et al.
Antimicrobial resistance is a growing global healthcare crisis, driven by the rapid spread of resistant pathogens that compromise existing treatments. Carbapenem-resistant Klebsiella pneumoniae is a major public health threat, requiring nov...
Functional characterization of macrolide esterase from cyanobacteria and their potential dissemination risk [0.03%]
来自蓝藻的巨抗生素酯酶的功能表征及其潜在传播风险
Hongkun Tao,Liwei Zhou,Yang Zhou et al.
Hongkun Tao et al.
The global dissemination of antibiotic resistance genes (ARGs) across diverse environments has emerged as a critical challenge to public health. As essential primary producers, Cyanobacteria colonize extreme and heterogeneous habitats, coex...
Genomic landscape of antimicrobial resistance in India: findings from a multi-species surveillance study [0.03%]
印度抗菌药物抵抗基因组特征：一项多物种监测研究的结果
Nazneen Gheewalla,Vasundhara Karthikeyan,Yuvraj Jadhav et al.
Nazneen Gheewalla et al.
Antimicrobial resistance (AMR) is a major public health threat, especially in low- and middle-income countries (LMICs), where large datasets linking antimicrobial susceptibility testing (AST) with genomic data remain limited. We analyzed AS...
Global response to antibiotic exposure reveals a critical role for nucleotide metabolism in high-level β-lactam tolerance [0.03%]
全球抗生素暴露反应揭示了核苷酸代谢在高水平β-内酰胺耐受性中的关键作用
Megan Renee Keller,Misha Iqbal Kazi,Anas Saleh et al.
Megan Renee Keller et al.
Antibiotic tolerance, the ability to survive lethal antibiotics for a prolonged period of time is a rising threat due to its role as a steppingstone towards antibiotic resistance. While tolerance has been recognized as a severe clinical thr...
Prevalence and patterns of antimicrobial resistance among wildlife populations in Africa: a systematic review [0.03%]
非洲野生动物种群中抗菌素耐药性的流行率和特征的系统评价
Jemimmah W Mwangi,Anne Kimeu,Arshnee Moodley et al.
Jemimmah W Mwangi et al.
Antimicrobial resistance (AMR) is increasingly reported in wildlife, yet evidence from Africa remains fragmented. We conducted a systematic review of AMR in African wildlife, screening 4,802 records and including 61 studies from 21 countrie...