Global emergence, evolution and international dissemination of the ST145 Klebsiella oxytoca lineage [0.03%]
全球范围内的克雷伯氏肺炎杆菌ST145系的出现、进化及国际传播
Shangshang Qin,Zhiyang Yu,Yanlei Shen et al.
Shangshang Qin et al.
Klebsiella oxytoca is an under-recognised opportunistic pathogen increasingly associated with severe antimicrobial-resistant infections. Here, we report the first carbapenemase-producing K. oxytoca (CPKO) isolate co-harbouring blaKPC-2 and ...
Environmental dissemination of multidrug-resistant Escherichia coli across one health interfaces in Mymensingh, Bangladesh [0.03%]
孟加拉国Mymensingh地区多药耐药大肠杆菌在人类、动物和环境之间的传播状况调查研究
Aninda Rahman,Sangjukta Roy,Nawroz Afreen et al.
Aninda Rahman et al.
Environmental dissemination of antimicrobial-resistant Escherichia coli is a major One Health challenge in Bangladesh. This study assessed the occurrence of third-generation cephalosporin and carbapenem-resistant E. coli across key environm...
Candidozyma auris-infected Galleria mellonella larvae: the effect of the humanized monoclonal antibody Dia-T51 and its synergy with amphotericin B [0.03%]
人源化单克隆抗体Dia-T51和其与两性霉素B联合应用于Candidozyma auris感染的家蚕幼虫的效果研究
Tania Vanzolini,Valentina Fiori,Mauro Magnani
Tania Vanzolini
Fungal infections pose a major worldwide health risk, as newly emerging pathogens and the increasing spread of drug resistance are now severely challenging current therapeutic and diagnostic tools. Candidozyma auris embodies both of these a...
Changes in antimicrobial resistance profiles of Escherichia coli and the metagenome on Dutch pig farms after antimicrobial usage interventions [0.03%]
减少抗菌药物使用对荷兰养猪场大肠杆菌耐药性及微生物群落的影响分析
R E C Luiken,H Prinsen,S N Dasari et al.
R E C Luiken et al.
The use of antimicrobials in livestock farming drives selection and dissemination of antimicrobial resistance (AMR), prompting implementation of veterinary stewardship programs to reduce antimicrobial usage (AMU). We evaluated changes in AM...
Distinct infant resistome trajectories shaped by country income and geography revealed through global metagenomics reanalysis [0.03%]
基于全球元基因组重测序的收入水平和地理因素塑造的独特婴儿抗菌素耐药基因群动态轨迹
Charlie C Luchen,Gonçalo J Piedade,Mwelwa Chibuye et al.
Charlie C Luchen et al.
Antimicrobial resistance (AMR) costs lives, diminishes antimicrobial effectiveness and increases health care costs. We conducted a re-analysis of pooled fecal metagenomes from individual participants to characterise AMR gene (ARG) distribut...
Mechanistic insights into plasmid transfer inhibition in Enterobacterales by nucleoside analogues [0.03%]
核苷类似物抑制肠杆菌目质粒转移的机制研究
Ilyas Alav,Ayesha Ashraf,Parisa Pordelkhaki et al.
Ilyas Alav et al.
Antimicrobial resistance (AMR) poses a major global health threat, with carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales causing widespread infections and deaths. Much of this resistance spreads thro...
Selection of porin and LPS mutants during infection by phage T4 facilitates the emergence of β-lactam resistance in Escherichia coli [0.03%]
侵袭性噬菌体T4选择的大肠杆菌porin和LPS突变体促进β-内酰胺耐药的产生
Justine Le-Boulch,Erika Charneau,Anne Chevallereau et al.
Justine Le-Boulch et al.
Understanding all sources of selective pressure that contribute to the emergence of antibiotic resistance is essential for developing sustainable antimicrobial strategies. Here, we investigated the interaction between phage T4 and Escherich...
Bacterial cell fate under stress: lipid remodeling and antimicrobial peptide attack [0.03%]
压力下细菌细胞的命运：脂质重塑和抗菌肽攻击
Djenana Vejzovic,Theresa Schwaiger,Altea Topciu et al.
Djenana Vejzovic et al.
Dynamic changes in lipid membrane composition are a common response to stress, often involving shifts in key lipid molecules. Phosphatidic acid (PA), a central precursor in lipid biosynthesis, accumulates when anionic phospholipid synthesis...
Artificial intelligence for early detection and risk prediction of antimicrobial resistance in aquatic ecosystems [0.03%]
人工智能在水生生态系统中抗菌药物耐药的早期检测和风险预测中的作用
William Calero-Cáceres,Ronan Adler Tavella,Fábio Parra Sellera et al.
William Calero-Cáceres et al.
Aquatic environments are key reservoirs and dissemination pathways of antimicrobial resistance (AMR). However, current water-based surveillance remains fragmented and inefficient for the timely detection of emerging threats. Integrating art...
Fate of the resistance profile of drinking water biofilm exposed to a sub-minimum inhibitory concentration of ciprofloxacin [0.03%]
暴露于环丙沙星亚抑菌浓度下的饮用水生物膜耐药性命运研究
Victoria Rilstone,Yves Filion,Pascale Champagne
Victoria Rilstone
Early research has found that biofilms adhered to treatment filtration beds and the inside of drinking water pipes help promote antimicrobial resistance (AMR) in drinking water systems. This study investigates the impact of a sub-minimum in...