Prediction of antimicrobial minimum inhibitory concentration from bacterial genomes using a scalable and interpretable machine learning approach [0.03%]
一种可扩展且解释性强的机器学习方法预测细菌基因组的抗菌最低抑制浓度
Alessandro Gerada,Yinzheng Zhong,Nicholas Harper et al.
Alessandro Gerada et al.
Although machine learning models can predict antimicrobial susceptibility from bacterial whole genome sequencing (WGS), state-of-the-art approaches are computationally demanding or dependent on knowledge of genetic resistance determinants. ...
Harnessing generative AI for predicting and optimizing antimicrobial peptides against drug-resistant infections [0.03%]
利用生成式人工智能预测和优化抗菌肽以对抗耐药性感染
Sandra Clemens,Hannah Franziska Löchel,Nico Häußer et al.
Sandra Clemens et al.
Antimicrobial resistance (AMR) poses a major global health threat that demands the discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) offer a promising therapeutic alternative due to their broad-spectrum activity and reduc...
Impact of co-amoxiclav versus amoxicillin on the gastrointestinal microbiota in sub-Saharan children hospitalized with pneumonia [0.03%]
在撒哈拉以南住院肺炎儿童中，替莫西林与氨苄西林对肠道微生物群的影响研究
Juan Pablo Rodriguez-Ruiz,Servaas Hiel,Victor Musiime et al.
Juan Pablo Rodriguez-Ruiz et al.
Community-acquired pneumonia (CAP) causes high pediatric mortality especially in sub-Saharan Africa. In a secondary analysis of samples from the PediCAP trial (ISRCTN63115131), we tracked gastrointestinal resistome and microbiota dynamics o...
resLens: genomic language models to enhance antibiotic resistance gene detection [0.03%]
基于基因组的语言模型在抗生素抗性基因检测中的应用提升
Matthew Mollerus,Katharina Dittmar,Keith A Crandall et al.
Matthew Mollerus et al.
The rise of antibiotic resistance necessitates advanced tools to detect and analyze antibiotic resistance genes (ARGs). We present resLens, a family of genomic language models that leverage latent genomic representations to enhance ARG dete...
Gene expression plasticity under multiple stresses drives higher tolerance to a macrolide in saline and warmer environments [0.03%]
多胁迫下的基因表达可塑性在盐度和温度升高条件下产生对大环内酯类的更高耐受性
Marie Rescan,Marc Dachs Rojo,Carles M Borrego
Marie Rescan
The widespread presence of antibiotics in the environment at sub-inhibitory concentrations imposes a selective pressure that promotes the spread of resistance. In the field, antibiotics interact with diverse physicochemical parameters that ...
Mind the governance gap: a one health scoping review of national AMR performance indicators [0.03%]
关注治理差距：国家抗微生物药物耐药性绩效指标的“同一健康”综述研究
Emily T O&#x;Neill,Uswa Shafaque,Vassilis Karadimitris et al.
Emily T O&#x;Neill et al.
Despite several initiatives to benchmark national action in responding to antimicrobial resistance (AMR), no comprehensive inventory exists of indicators used across these efforts. We present a scoping review that maps and synthesises exist...
Hazera Khatun Koly,Roha Razzaq,Tahmina Hossain et al.
Hazera Khatun Koly et al.
The threat of antibiotic-resistant bacteria is rapidly escalating, creating an urgent need for new types of antimicrobials. Although most antibiotics act by disrupting essential cellular processes, such as cell division, replication, transc...
Phenotypic convergence and collateral susceptibility development in Pseudomonas aeruginosa under antibiotic exposure in ICU patients [0.03%]
铜绿假单胞菌在重症监护病房患者中接触抗生素时的表型趋同和伴随易感性发展
Thomas E van der Schalk,Matilda Berkell,An Hottebeekx et al.
Thomas E van der Schalk et al.
Antibiotic combination therapy is often used to broaden the antimicrobial spectrum, limit resistance and improve treatment efficacy. Several antibiotics show collateral effects where resistance to one antibiotic increases susceptibility to ...
A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy [0.03%]
铂系蝴蝶效应：微小变化使抗癌药物成为具有体内有效性的非毒性金属抗生素
Çağrı Özsan,Ann-Britt Schäfer,Abdul Akhir et al.
Çağrı Özsan et al.
Metal-based compounds have emerged as a promising class of potential antibiotics exhibiting high hit-rates against critical bacterial pathogens while not displaying higher toxicity than organic compounds. Here, we describe the exploration o...
Molecular mechanism of transition-state inhibitors of bacterial antibiotic efflux pumps [0.03%]
细菌抗生素外排泵过渡态抑制剂的分子机制
Clara Börnsen,Reinke T Müller,Anais Vieira Da Cruz et al.
Clara Börnsen et al.
In many Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae, the AcrAB-TolC efflux pump is central to multidrug resistance. We report the development of BDM91531, a nanomolar pyridylpiperazine inhibitor that potentiate...