Phenotypic convergence and collateral susceptibility development in Pseudomonas aeruginosa under antibiotic exposure in ICU patients [0.03%]
铜绿假单胞菌在重症监护病房患者中接触抗生素时的表型趋同和伴随易感性发展
Thomas E van der Schalk,Matilda Berkell,An Hottebeekx et al.
Thomas E van der Schalk et al.
Antibiotic combination therapy is often used to broaden the antimicrobial spectrum, limit resistance and improve treatment efficacy. Several antibiotics show collateral effects where resistance to one antibiotic increases susceptibility to ...
A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy [0.03%]
铂系蝴蝶效应：微小变化使抗癌药物成为具有体内有效性的非毒性金属抗生素
Çağrı Özsan,Ann-Britt Schäfer,Abdul Akhir et al.
Çağrı Özsan et al.
Metal-based compounds have emerged as a promising class of potential antibiotics exhibiting high hit-rates against critical bacterial pathogens while not displaying higher toxicity than organic compounds. Here, we describe the exploration o...
Molecular mechanism of transition-state inhibitors of bacterial antibiotic efflux pumps [0.03%]
细菌抗生素外排泵过渡态抑制剂的分子机制
Clara Börnsen,Reinke T Müller,Anais Vieira Da Cruz et al.
Clara Börnsen et al.
In many Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae, the AcrAB-TolC efflux pump is central to multidrug resistance. We report the development of BDM91531, a nanomolar pyridylpiperazine inhibitor that potentiate...
Molecular action of NZ2114, a superior plectasin derivative [0.03%]
NZ2114的分子作用机制研究——一种优良的Plectasin衍生物
Maik G N Derks,Shehrazade Jekhmane,Sourav Maity et al.
Maik G N Derks et al.
NZ2114 is a triple-mutant of the natural peptide antibiotic plectasin that targets the peptidoglycan precursor molecule Lipid II using a supramolecular action, involving assembly of plectasin-Lipid II complexes in a large oligomeric structu...
Molecular epidemiology of OXA-1054, a novel carbapenem-hydrolysing Class D β-lactamase, in Enterobacteriaceae isolated from wastewaters [0.03%]
来自废水中肠杆菌科菌株的新颖碳青霉烯酶OXA-1054的分子流行病学特征研究
Laura Monge-Olivares,Lucía González-Pinto,Marina R Pulido et al.
Laura Monge-Olivares et al.
Class D carbapenemase-producing Enterobacteriaceae have spread globally in recent decades. The increasing detection of novel variants, often differing by amino acid substitutions or deletions in the β5-β6 loop of OXA-48 or OXA-372 lineage...
Antimicrobial resistance, conjugative plasmids and pathogenicity in wastewater and freshwater Escherichia spp. in Stockholm, Sweden [0.03%]
瑞典斯德哥尔摩的污水处理和淡水中的抗微生物药物抗性、接合质粒和致病性在内的肠杆菌科菌种分布研究
Annie Justh de Neczpal,Kaisa Thorell,Laurens Tuts et al.
Annie Justh de Neczpal et al.
To investigate antibiotic resistance genes (ARGs), conjugative plasmids, and virulence genes in Swedish waterborne Escherichia spp., water samples were collected from urban freshwater and Baltic Sea beaches and a primary wastewater treatmen...
Accelerating natural product discovery with linked MS-genomics and language/transformer-based models [0.03%]
基于链接的质谱和基因组以及语言/变换器模型加速天然产物发现
Dillon W P Tay,Winston Koh,Shi Jun Ang et al.
Dillon W P Tay et al.
Integrated chem-bio characterization of microbial strain libraries can streamline natural product discovery by prioritizing candidate producers. Here, we employ language- and transformer-based models to extract actionable insights from link...
Antimicrobial peptide-induced inner membrane hyperpolarization is associated with antibiotic sensitization and attenuated MIC escalation in multidrug-resistant Gram-negative pathogens [0.03%]
抗微生物肽诱导的内膜超极化与抗生素增敏和多药耐药革兰氏阴性病原体的最小抑菌浓度升高抑制有关
Jih-Chao Yeh,Prakash Kishore Hazam,You-Ying Lin et al.
Jih-Chao Yeh et al.
Antimicrobial resistance and dysregulated inflammation drive mortality in multidrug-resistant (MDR) sepsis. We evaluated the cationic peptide TP2-5 as a low-dose antibiotic adjuvant. At sub-MIC concentrations, TP2-5 enhanced antibiotic susc...
NV716 acts as an envelope-active adjuvant that enhances antibiotic accumulation in Pseudomonas aeruginosa [0.03%]
NV716作为包膜活化型佐剂，可增强其在绿脓杆菌中抗生素的聚集作用
Margot Draveny,Hugo Chauvet,Axelle De Pauw et al.
Margot Draveny et al.
Treatment of Gram-negative infections remains challenging due to limited compound penetration and the presence of efflux mechanisms. Pseudomonas aeruginosa, in particular, exhibits strong intrinsic resistance, leaving few effective therapeu...
Overcoming Trypanosoma cruzi persistence with a mechanistically distinct drug combination [0.03%]
具有不同作用机制的药物联合克服克查加分枝泡虫病的持续存在
Amanda Fortes Francisco,Francisco Olmo,Fanny Escudié et al.
Amanda Fortes Francisco et al.
Infections with the protozoan parasite Trypanosoma cruzi are widespread in the Americas and can lead to severe cardiac and/or gastrointestinal pathology. Current treatments are limited to monotherapies characterised by prolonged dosing regi...