Polymerase-inhibitor drug synergy and mutational signatures in different epithelial cell models of RSVA and hPIV3 infection [0.03%]
RSVA和hPIV3感染的不同上皮细胞模型中的聚合酶抑制剂药物协同作用及突变特征
Samuel Ellis,Amy I Jacobs,Shengyuan Zhang et al.
Samuel Ellis et al.
Despite the huge global health burden presented by respiratory viruses, effective broad-spectrum antiviral therapeutic options remain limited. Here we evaluated the antiviral activity of four RNA-dependent RNA polymerase (RdRp) inhibitors, ...
Addressing the dual-use of antifungals and fungal antimicrobial resistance (fAMR) through a One Health approach [0.03%]
通过“同一健康”方法解决抗真菌药物的双重用途和真菌抗菌耐药性问题
S Weeks,A Brown,K Doughty et al.
S Weeks et al.
Fungal antimicrobial resistance (fAMR) is accelerating, driven in part by the dual-use of antifungal modes of action in agriculture and medicine, threatening therapy. Addressing this challenge requires a unified One Health response that bal...
Biofilm-driven LPS remodeling and colanic acid overproduction mediate biocide adaptation and antibiotic cross-resistance in E. coli [0.03%]
生物被膜驱动的LPS重塑和荚膜酸过量产生介导了大肠杆菌中的消毒剂适应性和抗生素交叉耐药性
Raphaël Charron,Pierre Lemée,Thibaut Léger et al.
Raphaël Charron et al.
The identification of the determinants driving antimicrobial resistance is a prerequisite for improving the control of resistance emergence and dissemination. Disinfectant biocides, daily used in food-processing industries, have already bee...
Prediction of antimicrobial minimum inhibitory concentration from bacterial genomes using a scalable and interpretable machine learning approach [0.03%]
一种可扩展且解释性强的机器学习方法预测细菌基因组的抗菌最低抑制浓度
Alessandro Gerada,Yinzheng Zhong,Nicholas Harper et al.
Alessandro Gerada et al.
Although machine learning models can predict antimicrobial susceptibility from bacterial whole genome sequencing (WGS), state-of-the-art approaches are computationally demanding or dependent on knowledge of genetic resistance determinants. ...
Harnessing generative AI for predicting and optimizing antimicrobial peptides against drug-resistant infections [0.03%]
利用生成式人工智能预测和优化抗菌肽以对抗耐药性感染
Sandra Clemens,Hannah Franziska Löchel,Nico Häußer et al.
Sandra Clemens et al.
Antimicrobial resistance (AMR) poses a major global health threat that demands the discovery of new antimicrobial agents. Antimicrobial peptides (AMPs) offer a promising therapeutic alternative due to their broad-spectrum activity and reduc...
Impact of co-amoxiclav versus amoxicillin on the gastrointestinal microbiota in sub-Saharan children hospitalized with pneumonia [0.03%]
在撒哈拉以南住院肺炎儿童中，替莫西林与氨苄西林对肠道微生物群的影响研究
Juan Pablo Rodriguez-Ruiz,Servaas Hiel,Victor Musiime et al.
Juan Pablo Rodriguez-Ruiz et al.
Community-acquired pneumonia (CAP) causes high pediatric mortality especially in sub-Saharan Africa. In a secondary analysis of samples from the PediCAP trial (ISRCTN63115131), we tracked gastrointestinal resistome and microbiota dynamics o...
resLens: genomic language models to enhance antibiotic resistance gene detection [0.03%]
基于基因组的语言模型在抗生素抗性基因检测中的应用提升
Matthew Mollerus,Katharina Dittmar,Keith A Crandall et al.
Matthew Mollerus et al.
The rise of antibiotic resistance necessitates advanced tools to detect and analyze antibiotic resistance genes (ARGs). We present resLens, a family of genomic language models that leverage latent genomic representations to enhance ARG dete...
Gene expression plasticity under multiple stresses drives higher tolerance to a macrolide in saline and warmer environments [0.03%]
多胁迫下的基因表达可塑性在盐度和温度升高条件下产生对大环内酯类的更高耐受性
Marie Rescan,Marc Dachs Rojo,Carles M Borrego
Marie Rescan
The widespread presence of antibiotics in the environment at sub-inhibitory concentrations imposes a selective pressure that promotes the spread of resistance. In the field, antibiotics interact with diverse physicochemical parameters that ...
Mind the governance gap: a one health scoping review of national AMR performance indicators [0.03%]
关注治理差距：国家抗微生物药物耐药性绩效指标的“同一健康”综述研究
Emily T O&#x;Neill,Uswa Shafaque,Vassilis Karadimitris et al.
Emily T O&#x;Neill et al.
Despite several initiatives to benchmark national action in responding to antimicrobial resistance (AMR), no comprehensive inventory exists of indicators used across these efforts. We present a scoping review that maps and synthesises exist...
Hazera Khatun Koly,Roha Razzaq,Tahmina Hossain et al.
Hazera Khatun Koly et al.
The threat of antibiotic-resistant bacteria is rapidly escalating, creating an urgent need for new types of antimicrobials. Although most antibiotics act by disrupting essential cellular processes, such as cell division, replication, transc...