Invasion dynamics of antimicrobial-resistant E. coli in river biofilms: impacts on the resistome, microbiomes, and horizontal gene transfer [0.03%]
抗微生物药物耐药性大肠杆菌在河流生物膜中的入侵动力学：对耐药基因组、微生物组和水平基因转移的影响
Giulia Gionchetta,Jangwoo Lee,Oliver Hansen et al.
Giulia Gionchetta et al.
River biofilms are frequently exposed to invasion by antibiotic-resistant bacteria (ARB) due to episodic or chronic wastewater inputs, yet the ecological processes governing the fate of invaders and their resistance plasmids remain poorly u...
Antimicrobial resistance among clinical isolates associated with combat-related infections in Ukraine: first nationwide surveillance, 2023-2024 [0.03%]
乌克兰作战相关感染临床分离株的抗菌药物耐药性监测（2023-2024年）首次全国调查
Ludmila Kasatkina,Ihnat Havrylov,Anzhela Sboieva et al.
Ludmila Kasatkina et al.
Antimicrobial resistance (AMR) is a critical global health threat, which reduces the effectiveness of treatment and drives higher morbidity, mortality, and costs. In Ukraine, the problem has been further aggravated by Russia's full-scale in...
Mapping the genomic landscape of antibiotic susceptiblity in Escherichia coli [0.03%]
抗生素敏感性的遗传图谱：以大肠杆菌为例
Sarah Bastkowski,A Keith Turner,Muhammad Yasir et al.
Sarah Bastkowski et al.
Antibiotic treatment failure is frequently driven by bacterial insusceptibility, yet understanding of the full repertoire of genes contributing to this in Gram-negative bacteria remains incomplete. We used TraDIS-Xpress, a high-density tran...
AMR in wild animals and plants: global trends and future priorities in wildlife-associated antimicrobial resistance research [0.03%]
野生动物中抗菌药物耐药性的全球趋势及未来研究重点
Holly J Tipper,Rachel A Payne,Isobel C Stanton et al.
Holly J Tipper et al.
Antimicrobial resistance (AMR) is a major global health concern, involving complex transmission pathways linking humans, domestic animals, wildlife, and the environment. Wild animals and plants can harbour and transmit AMR, while also servi...
Metagenomic profiling reveals shared resistome signatures between humans and pigs in Vietnamese smallholder farms [0.03%]
元基因组分析揭示了越南小型农场的人类和猪之间共享的抗性组特征
Le Thi Kieu Linh,Truong Nhat My,Nhat Thi Tran et al.
Le Thi Kieu Linh et al.
Antimicrobial resistance (AMR) is a global health concern, yet the extent of resistant genes and microbial exchange between humans and livestock in low- and middle-income countries remains underexplored. Vietnam, an AMR hotspot, was studied...
Exploiting DprE2 pathway redundancy to enhance potency and overcome resistance to pretomanid in Mycobacterium tuberculosis [0.03%]
利用DprE2途径的冗余性增强pretomanid对耐药结核分枝杆菌的活性
Kamel Djaout,Aurore Dreneau,Léo Faion et al.
Kamel Djaout et al.
Tuberculosis (TB), the deadliest infectious disease globally, still poses an enormous public health challenge exacerbated by the rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) M. tuberculosis strains. The bicyclic n...
Machine learning-based discovery of GW3965 as a therapeutic compound against invasive emm92-type group A Streptococcus [0.03%]
基于机器学习发现GW3965作为侵袭性emm92型A群链球菌感染的治疗化合物
Lillie M Powell,Megan E Grund,Wenxian Shi et al.
Lillie M Powell et al.
A multi-drug resistant emm92-type strain of group A Streptococcus (GAS) has emerged as an important causative agent of invasive infections-particularly affecting people who inject drugs-in the United States. To curtail this developing threa...
Polymerase-inhibitor drug synergy and mutational signatures in different epithelial cell models of RSVA and hPIV3 infection [0.03%]
RSVA和hPIV3感染的不同上皮细胞模型中的聚合酶抑制剂药物协同作用及突变特征
Samuel Ellis,Amy I Jacobs,Shengyuan Zhang et al.
Samuel Ellis et al.
Despite the huge global health burden presented by respiratory viruses, effective broad-spectrum antiviral therapeutic options remain limited. Here we evaluated the antiviral activity of four RNA-dependent RNA polymerase (RdRp) inhibitors, ...
Addressing the dual-use of antifungals and fungal antimicrobial resistance (fAMR) through a One Health approach [0.03%]
通过“同一健康”方法解决抗真菌药物的双重用途和真菌抗菌耐药性问题
S Weeks,A Brown,K Doughty et al.
S Weeks et al.
Fungal antimicrobial resistance (fAMR) is accelerating, driven in part by the dual-use of antifungal modes of action in agriculture and medicine, threatening therapy. Addressing this challenge requires a unified One Health response that bal...
Biofilm-driven LPS remodeling and colanic acid overproduction mediate biocide adaptation and antibiotic cross-resistance in E. coli [0.03%]
生物被膜驱动的LPS重塑和荚膜酸过量产生介导了大肠杆菌中的消毒剂适应性和抗生素交叉耐药性
Raphaël Charron,Pierre Lemée,Thibaut Léger et al.
Raphaël Charron et al.
The identification of the determinants driving antimicrobial resistance is a prerequisite for improving the control of resistance emergence and dissemination. Disinfectant biocides, daily used in food-processing industries, have already bee...