Transition metal homoeostasis is key to metabolism and drug tolerance of Mycobacterium abscessus [0.03%]
过渡金属稳态是脓肿分枝杆菌代谢和耐药性的关键因素
Yi Liu,Katy Murphy,Nadia Fernandes et al.
Yi Liu et al.
Antimicrobial resistance (AMR) is one of the major challenges humans are facing this century. Understanding the mechanisms behind the rise of AMR is therefore crucial to tackling this global threat. The presence of transition metals is one ...
Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant Candida auris [0.03%]
基因组流行病学描述了抗真菌药物耐药性白色念珠菌的传入和爆发
Dana Kappel,Hugh Gifford,Amelie Brackin et al.
Dana Kappel et al.
Candida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We anal...
Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity of Candida albicans [0.03%]
一种天然的S-腺苷甲硫氨酸核苷类似物Sinefungin可损害白色念珠菌的致病性
Anushka Nayak,Azam Khedri,Alejandro Chavarria et al.
Anushka Nayak et al.
Candida albicans, an opportunistic fungal pathogen, causes life-threatening infections in immunocompromised patients. Current antifungals are limited by toxicity, drug-drug interactions, and emerging resistance, underscoring the importance ...
The re-emergence of sexually transmissible multidrug resistant Shigella flexneri 3a, England, United Kingdom [0.03%]
英国英格兰引起性传播的多重耐药痢疾杆菌血清型3a卷土重来
Lewis C E Mason,Hannah Charles,Katie Thorley et al.
Lewis C E Mason et al.
Shigellosis is an enteric infection that transmits through the faecal-oral route, which can occur during sex between men who have sex with men (MSM). Between 2009 and 2014, an epidemic of sexually transmissible Shigella flexneri 3a occurred...
The effect of antibiotic selection on collateral effects and evolvability of uropathogenic Escherichia coli [0.03%]
抗生素选择对尿路致病性大肠杆菌的协同效应和进化能力的影响
Beth James,Hishikha Reesaul,Sidra Kashif et al.
Beth James et al.
Trimethoprim is recommended as a first-line treatment of urinary tract infections (UTIs) in the UK. In 2018, 31.4% of Escherichia coli isolated from UTIs in England were trimethoprim-resistant, leading to overreliance on other first and sec...
Modelling the impact of wastewater flows and management practices on antimicrobial resistance in dairy farms [0.03%]
废水流量和管理措施对奶牛场抗生素抗性的影响机制及数学模型研究
Henry Todman,Richard Helliwell,Liz King et al.
Henry Todman et al.
Dairy slurry is a major source of environmental contamination with antimicrobial resistant genes and bacteria. We developed mathematical models and conducted on-farm research to explore the impact of wastewater flows and management practice...
Demographic fluctuations in bloodstream Staphylococcus aureus lineages configure the mobile gene pool and antimicrobial resistance [0.03%]
血流感染的金黄色葡萄球菌谱系的人群波动配置可移动基因库及抗菌药物抗性
Stephanie S R Souza,Joshua T Smith,Michael M Marcovici et al.
Stephanie S R Souza et al.
Staphylococcus aureus in the bloodstream causes high morbidity and mortality, exacerbated by the spread of multidrug-resistant and methicillin-resistant S. aureus (MRSA). We aimed to characterize the circulating lineages of S. aureus from b...
The impact of antibiotics on the gut microbiota of children recovering from watery diarrhoea [0.03%]
抗生素对恢复期水样腹泻儿童肠道菌群的影响
Son-Nam H Le,Chau Nguyen Ngoc Minh,Paola Florez de Sessions et al.
Son-Nam H Le et al.
Infectious diarrhoeal diseases remain a substantial health burden in young children in low- and middle-income countries. The disease and its variable treatment options significantly alter the gut microbiome, which may affect clinical outcom...
Using next generation antimicrobials to target the mechanisms of infection [0.03%]
利用新一代抗菌药物针对感染机制进行靶向治疗
Kavita Gadar,Ronan R McCarthy
Kavita Gadar
The remarkable impact of antibiotics on human health is being eroded at an alarming rate by the emergence of multidrug resistant pathogens. There is a recognised consensus that new strategies to tackle infection are urgently needed to limit...
Interpretable machine learning-based decision support for prediction of antibiotic resistance for complicated urinary tract infections [0.03%]
基于解释型机器学习的复杂尿路感染抗生素耐药性预测决策支持系统
Jenny Yang,David W Eyre,Lei Lu et al.
Jenny Yang et al.
Urinary tract infections are one of the most common bacterial infections worldwide; however, increasing antimicrobial resistance in bacterial pathogens is making it challenging for clinicians to correctly prescribe patients appropriate anti...