Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain [0.03%]
口服抗生素治疗慢性下背痛的椎间盘内药代动力学研究
Lloyd G Czaplewski,Marcus Zeitlinger,Joseph F Standing
Lloyd G Czaplewski
Oral coamoxiclav and amoxicillin, for extended dose regimens of up to 100 days, have shown benefit in the treatment of Chronic Lower Back Pain (CLBP) associated with vertebral bone oedema, known as Modic type 1 changes, which may be caused ...
Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments [0.03%]
资源匮乏的鸡猪养殖环境中抗生素生态毒理学和抗性风险
Fredrick Gudda,Dishon Muloi,Fredrick Nganga et al.
Fredrick Gudda et al.
Antimicrobial resistance (AMR) data from agroecosystems in low- and middle-income countries is limited. We surveyed chicken (n = 52) and pig (n = 47) farms in Kenya to understand AMR in animal-environment pathways. Using LC-MS/MS, we valida...
Phage therapy could be key to conquering persistent bacterial lung infections in children [0.03%]
噬菌体疗法可能是治疗儿童难治性细菌肺部感染的关键
Aye Mya Sithu Shein,Parichart Hongsing,Aisha Khatib et al.
Aye Mya Sithu Shein et al.
Persistent bacterial lung infections in children lead to significant morbidity and mortality due to antibiotic resistance. In this paper, we describe how phage therapy has shown remarkable efficacy in preclinical and clinical studies, demon...
Narrative review of recent developments and the future of penicillin allergy de-labelling by non-allergists [0.03%]
非过敏症医师进行青霉素过敏脱敏的近期进展和未来前景系统评价
Neil Powell,Michael Blank,Akish Luintel et al.
Neil Powell et al.
This article outlines recent developments in non-allergist delivered penicillin allergy de-labelling (PADL), discusses remaining controversies and uncertainties and explores the future for non-allergist delivered PADL. Recent developments i...
Two classes of DNA gyrase inhibitors elicit distinct evolutionary trajectories toward resistance in gram-negative pathogens [0.03%]
两类DNA解旋酶抑制剂诱导革兰氏阴性病原体产生抵抗性的不同进化路径
Semen A Leyn,James E Kent,Jaime E Zlamal et al.
Semen A Leyn et al.
Comprehensive knowledge of mechanisms driving the acquisition of antimicrobial resistance is essential for the development of new drugs with minimized resistibility. To gain this knowledge, we combine experimental evolution in a continuous ...
Stalled ribosome rescue factors exert different roles depending on types of antibiotics in Escherichia coli [0.03%]
stalled 核糖体救援因子根据抗生素的类型在大肠杆菌中发挥不同的作用
Mayu Mikami,Hidehiko Shimizu,Norika Iwama et al.
Mayu Mikami et al.
Escherichia coli possesses three stalled-ribosome rescue factors, tmRNA·SmpB (primary factor), ArfA (alternative factor to tmRNA·SmpB), and ArfB. Here, we examined the susceptibility of rescue factor-deficient strains from E. coli SE15 to...
Cystic fibrosis sputum media induces an overall loss of antibiotic susceptibility in Mycobacterium abscessus [0.03%]
囊性纤维化患者痰标本培养基可导致鸟分枝杆菌复合体中山田型耐药性增加
Emily J Baker,Gemma Allcott,Antonia Molloy et al.
Emily J Baker et al.
Mycobacterium abscessus complex (MABSC) comprises a group of environmental microorganisms, which are a concerning cause of opportunistic respiratory infections in patients with cystic fibrosis or bronchiectasis. Only 45.6% of MABSC treatmen...
The role of gene copy number variation in antimicrobial resistance in human fungal pathogens [0.03%]
人类病原性真菌中基因拷贝数变异在抗菌素耐药性中的作用
Adarsh Jay,David F Jordan,Aleeza Gerstein et al.
Adarsh Jay et al.
Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms. Fungi have relativel...
Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir [0.03%]
构建追踪持久性环境蓄积库中抗菌素耐药基因传播的框架
Amy J Mathers,Thomas J X Li,Qijun He et al.
Amy J Mathers et al.
Mobile genetic elements are key to the global emergence of antibiotic resistance. We successfully reconstructed the complete bacterial genome and plasmid assemblies of isolates sharing the same bla KPC carbapenemase gene to understand evolu...
Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo [0.03%]
感染生态系统和生物地理对体内抗生素失效的贡献
Rahan Rudland Nazeer,Isabel Askenasy,Jemima E V Swain et al.
Rahan Rudland Nazeer et al.
The acquisition of antibiotic resistance in bacteria, though a deeply concerning international issue, is reasonably well-understood at a mechanistic level. Less well-understood is why bacteria that are sensitive in vitro to well-established...