The role of gene copy number variation in antimicrobial resistance in human fungal pathogens [0.03%]
人类病原性真菌中基因拷贝数变异在抗菌素耐药性中的作用
Adarsh Jay,David F Jordan,Aleeza Gerstein et al.
Adarsh Jay et al.
Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms. Fungi have relativel...
Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir [0.03%]
构建追踪持久性环境蓄积库中抗菌素耐药基因传播的框架
Amy J Mathers,Thomas J X Li,Qijun He et al.
Amy J Mathers et al.
Mobile genetic elements are key to the global emergence of antibiotic resistance. We successfully reconstructed the complete bacterial genome and plasmid assemblies of isolates sharing the same bla KPC carbapenemase gene to understand evolu...
Contribution of the infection ecosystem and biogeography to antibiotic failure in vivo [0.03%]
感染生态系统和生物地理对体内抗生素失效的贡献
Rahan Rudland Nazeer,Isabel Askenasy,Jemima E V Swain et al.
Rahan Rudland Nazeer et al.
The acquisition of antibiotic resistance in bacteria, though a deeply concerning international issue, is reasonably well-understood at a mechanistic level. Less well-understood is why bacteria that are sensitive in vitro to well-established...
Á Tamás Gräff,Sarah M Barry
Á Tamás Gräff
In the search for iron, an essential element in many biochemical processes, microorganisms biosynthesise dedicated chelators, known as siderophores, to sequester iron from their environment and actively transport the siderophore complex int...
The putative error prone polymerase REV1 mediates DNA damage and drug resistance in Candida albicans [0.03%]
假定的错误易犯性聚合酶REV1在白色念珠菌中介导DNA损伤和药物抗性
Michelle R Agyare-Tabbi,Deeva Uthayakumar,Desiree Francis et al.
Michelle R Agyare-Tabbi et al.
Antimicrobial-induced DNA damage, and subsequent repair via upregulation of DNA repair factors, including error-prone translesion polymerases, can lead to the increased accumulation of mutations in the microbial genome, and ultimately incre...
Insights into durability against resistance from the antibiotic nitrofurantoin [0.03%]
新型耐药机制致使硝呋哃疗效下降
Riannah Kettlewell,Charlotte Jones,Timothy W Felton et al.
Riannah Kettlewell et al.
Nitrofurantoin has shown exceptional durability against resistance over 70 years of use. This longevity stems from factors such as rapid achievement of therapeutic concentrations, multiple physiological targets against bacteria, low risk of...
Cpx-signalling in Yersinia pseudotuberculosis modulates Lipid-A remodelling and resistance to last-resort antimicrobials [0.03%]
耶尔森菌假结核亚种中Cpx信号转导调节脂质A重构及对最后救命抗菌药物的耐药性
Dharmender K Gahlot,Jonasz B Patkowski,Jaime Fernández de Santaella et al.
Dharmender K Gahlot et al.
Antibiotic resistance is a global healthcare crisis. Bacteria are highly adaptable and can rapidly acquire mechanisms of resistance towards conventional antibiotics. The permeability barrier conferred by the Gram-negative bacteria cell enve...
A one health roadmap towards understanding and mitigating emerging Fungal Antimicrobial Resistance: fAMR [0.03%]
一项关于新兴的抗真菌耐药性（fAMR）的研究路线图以促进对fungamr的理解和缓解
Matthew C Fisher,Fiona Burnett,Clare Chandler et al.
Matthew C Fisher et al.
The emergence of fungal antimicrobial resistance-fAMR-is having a growing impact on human and animal health, and food security. This roadmap charts inter-related actions that will enhance our ability to mitigate the risk of fAMR. As humanit...
Changing epidemiology and antimicrobial susceptibility of bloodstream infections at a Vietnamese infectious diseases hospital (2010-2020) [0.03%]
越南传染病医院（2010-2020年）血流感染的流行病学和抗菌药物敏感性变化
Hoang Thu Trang Nguyen,Vinh Chau,Phu Huong Lan Nguyen et al.
Hoang Thu Trang Nguyen et al.
Bloodstream infection (BSI) poses a global health problem, with diverse organisms and rising antimicrobial resistance (AMR). Here, we characterized trends in BSI prevalence, AMR, and antibiotic use at a Vietnamese infectious diseases hospit...
Ho Yu Liu,Emma L Prentice,Mark A Webber
Ho Yu Liu
Most bacteria in nature exist in aggregated communities known as biofilms, and cells within a biofilm demonstrate major physiological changes compared to their planktonic counterparts. Biofilms are associated with many different types of in...