Polymicrobial infection in cystic fibrosis and future perspectives for improving Mycobacterium abscessus drug discovery [0.03%]
囊性纤维化患者的多重病原菌感染及未来提高鸟胞分枝杆菌药物发现效率的展望
Emily J Baker,Gemma Allcott,Jonathan A G Cox
Emily J Baker
Polymicrobial communities inhabit the cystic fibrosis (CF) airway, whereby microbial interactions can occur. One prominent CF pathogen is Mycobacterium abscessus, whose treatment is largely unsuccessful. This creates a need to discover nove...
Making microbes matter: storytelling's potential to make antibiotic resistance real and relevant to the public [0.03%]
妙趣话微生物——故事讲述让抗生素耐药性问题变得通俗易懂的潜力
Becky McCall,Laura Shallcross,Michael Wilson et al.
Becky McCall et al.
Multidrug efflux in Gram-negative bacteria: structural modifications in active compounds leading to efflux pump avoidance [0.03%]
革兰氏阴性菌多药外排：作用化合物结构修饰以避开外排泵
Dominik Gurvic,Ulrich Zachariae
Dominik Gurvic
Gram-negative bacteria cause the majority of critically drug-resistant infections, necessitating the rapid development of new drugs with Gram-negative activity. However, drug design is hampered by the low permeability of the Gram-negative c...
Population structure and ongoing microevolution of the emerging multidrug-resistant Salmonella Typhimurium ST213 [0.03%]
多重耐药的伤寒沙门氏菌ST213的群体结构及其基因组水平微进化研究
Isela Serrano-Fujarte,Edmundo Calva,Jimena García-Domínguez et al.
Isela Serrano-Fujarte et al.
Salmonella enterica serovar Typhimurium ST213 is an emergent multidrug-resistant sequence type associated with the food chain, and gastrointestinal and invasive infections in North America. Here, we applied genomic and phenotypic analyses t...
A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance [0.03%]
一种无细胞策略用于宿主特异性地分析胞内抗生素敏感性和抗性
Kameshwari Chengan,Charlotte Hind,Maria Stanley et al.
Kameshwari Chengan et al.
Antimicrobial resistance (AMR) is a pandemic spread across multiple infectious disease-causing microbes. To provide a host-specific tool to study antibiotic susceptibility and resistance, here we develop Klebsiella pneumoniae cell-free gene...
The Tol Pal system integrates maintenance of the three layered cell envelope [0.03%]
Tol Pal系统整合三层细胞包膜的维护功能
Joanna Szczepaniak,Melissa N Webby
Joanna Szczepaniak
The rapid emergence of antibiotic-resistant superbugs poses a significant global health threat. Gram-negative bacteria are the primary culprits due to their robust, tripartite cell envelope. This review explores the emerging role of the tra...
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition [0.03%]
用于铜绿假单胞菌MexXY-OprM外排功能及抑制研究的化学探针查尔酮二白芸豆碱化合物
Logan G Kavanaugh,Andrew R Mahoney,Debayan Dey et al.
Logan G Kavanaugh et al.
The Resistance-Nodulation-Division (RND) efflux pump superfamily is pervasive among Gram-negative pathogens and contributes extensively to clinical antibiotic resistance. The opportunistic pathogen Pseudomonas aeruginosa contains 12 RND-typ...
Policy options for sustainable access to off-patent antibiotics in Europe [0.03%]
在欧洲可持续获取专利到期抗生素的政策选择
Dimitra Panteli,Michael Anderson,Thomas Fieldman et al.
Dimitra Panteli et al.
Securing sustainable access to existing antibiotics optimises agent choice for individual treatments and is crucial to curb antibiotic resistance. Access to antibiotics is often restricted in many countries, due to general market unavailabi...
YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli [0.03%]
YgiV启动子突变导致大肠杆菌对cystobactamid类抗生素的耐药性并降低毒力因子表达
Timo Risch,Dominik Kolling,Dietrich Mostert et al.
Timo Risch et al.
Antimicrobial resistance is one of the major health threats of the modern world. Thus, new structural classes of antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids represent one such new compound cla...
Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance [0.03%]
揭开细胞代谢抑制在抗生素耐受性中的关键作用
Sayed Golam Mohiuddin,Han Ngo,Mehmet A Orman
Sayed Golam Mohiuddin
Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria, potentially acting as antagonists by inducing cell dormancy and promoting cell survival. However, the specific synergistic or antagonistic effects ...