Policy options for sustainable access to off-patent antibiotics in Europe [0.03%]
在欧洲可持续获取专利到期抗生素的政策选择
Dimitra Panteli,Michael Anderson,Thomas Fieldman et al.
Dimitra Panteli et al.
Securing sustainable access to existing antibiotics optimises agent choice for individual treatments and is crucial to curb antibiotic resistance. Access to antibiotics is often restricted in many countries, due to general market unavailabi...
YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli [0.03%]
YgiV启动子突变导致大肠杆菌对cystobactamid类抗生素的耐药性并降低毒力因子表达
Timo Risch,Dominik Kolling,Dietrich Mostert et al.
Timo Risch et al.
Antimicrobial resistance is one of the major health threats of the modern world. Thus, new structural classes of antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids represent one such new compound cla...
Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance [0.03%]
揭开细胞代谢抑制在抗生素耐受性中的关键作用
Sayed Golam Mohiuddin,Han Ngo,Mehmet A Orman
Sayed Golam Mohiuddin
Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria, potentially acting as antagonists by inducing cell dormancy and promoting cell survival. However, the specific synergistic or antagonistic effects ...
Aram F Swinkels,Egil A J Fischer,Lisa Korving et al.
Aram F Swinkels et al.
Fluoroquinolone resistance in E. coli isolates from livestock in Europe remains high despite EMA restrictions on fluoroquinolone use in animals. However, flumequine, a quinolone not classified as a fluoroquinolone by various regulatory bodi...
Regulation of erm(T) MLSB phenotype expression in the emergent emm92 type group A Streptococcus [0.03%]
新型emm92型A群链球菌中erm（T）MLS B表型表达的调节机制研究
Lillie M Powell,Soo Jeon Choi,Megan E Grund et al.
Lillie M Powell et al.
In the last decade, invasive group A Streptococcus (iGAS) infections have doubled in the US, with equivalent increases in MLSB (macrolide, lincosamide, and streptogramin B)-resistance. The emm92-type isolates carrying the erm(T) gene have b...
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe [0.03%]
赞比亚由多重耐药的血清型Kentucky肠炎沙门氏菌ST198引起临床感染和家禽中流行
Tapfumanei Mashe,Gaetan Thilliez,Blessmore V Chaibva et al.
Tapfumanei Mashe et al.
A highly multidrug-resistant strain of Salmonella enterica serotype Kentucky (S. Kentucky) of sequence type (ST)198 emerged in North Africa and has since spread widely. To investigate the genetic diversity and phylogenetic relationship of S...
Challenges and applications of artificial intelligence in infectious diseases and antimicrobial resistance [0.03%]
人工智能在传染病和抗菌素耐药性方面的挑战与应用
Angela Cesaro,Samuel C Hoffman,Payel Das et al.
Angela Cesaro et al.
Artificial intelligence (AI) has transformed infectious disease control, enhancing rapid diagnosis and antibiotic discovery. While conventional tests delay diagnosis, AI-driven methods like machine learning and deep learning assist in patho...
Tackling the outer membrane: facilitating compound entry into Gram-negative bacterial pathogens [0.03%]
突破外膜：促进化合物进入革兰氏阴性细菌病原体
Deepanshi Saxena,Rahul Maitra,Rakhi Bormon et al.
Deepanshi Saxena et al.
Emerging resistance to all available antibiotics highlights the need to develop new antibiotics with novel mechanisms of action. Most of the currently used antibiotics target Gram-positive bacteria while Gram-negative bacteria easily bypass...
Kalinga Pavan T Silva,Anupama Khare
Kalinga Pavan T Silva
Apart from horizontal gene transfer and sequence-altering mutational events, antibiotic resistance can emerge due to the formation of tandem repeats of genomic regions. This phenomenon, also known as gene amplification, has been implicated ...
Limitations of current techniques in clinical antimicrobial resistance diagnosis: examples and future prospects [0.03%]
临床抗菌药物耐药诊断技术的现状及未来展望：实例与分析
Jack Hassall,Carmen Coxon,Vishal C Patel et al.
Jack Hassall et al.
Antimicrobial resistance is a global threat to public health. Without proactive intervention, common infections may become untreatable, restricting the types of clinical intervention that can be undertaken and reversing improvements in mort...