Enrichment risk and drivers of manure-derived antibiotic resistance genes in black soldier fly larval gut [0.03%]
黑 SOLDIER FLY 幼虫肠道中抗生素抗性基因的富集风险及其驱动因素——以粪便为来源为例
Yiwen Yang,Yanhong Guo,Tong Xu et al.
Yiwen Yang et al.
Black soldier fly larvae (BSFL) are promising for converting animal manure into protein; however, the risk of antibiotic resistance gene (ARG) enrichment in the larval gut during this process remains unclear. Here, we employed metagenomic a...
Increased temperature selects for antibiotic resistance genes in a model aquatic ecosystem [0.03%]
升温选择了一种模型水生生态系统中的抗生素抗性基因
Emma Bousquet,Sabine Favre-Bonté,Thibault Meyer et al.
Emma Bousquet et al.
There is a rising concern that temperature increases associated with climate change might select for antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in aquatic ecosystems, although the extent of this phenomenon re...
National genomic surveillance reveals global plasmid and chromosomal dissemination routes of blaNDM-1 [0.03%]
国家范围内的基因组监测揭示了blaNDM-1的质粒和染色体传播路线
Ricardo Gutiérrez,Manuel Ramírez-Cardoce,Tábata Elizondo-Alvarez et al.
Ricardo Gutiérrez et al.
The global spread of New Delhi metallo-β-lactamase (NDM)-producing Gram-negative bacteria poses a major threat to healthcare systems worldwide, yet the processes driving their long-term establishment at national scales remain poorly unders...
Invasion dynamics of antimicrobial-resistant E. coli in river biofilms: impacts on the resistome, microbiomes, and horizontal gene transfer [0.03%]
抗微生物药物耐药性大肠杆菌在河流生物膜中的入侵动力学：对耐药基因组、微生物组和水平基因转移的影响
Giulia Gionchetta,Jangwoo Lee,Oliver Hansen et al.
Giulia Gionchetta et al.
River biofilms are frequently exposed to invasion by antibiotic-resistant bacteria (ARB) due to episodic or chronic wastewater inputs, yet the ecological processes governing the fate of invaders and their resistance plasmids remain poorly u...
Antimicrobial resistance among clinical isolates associated with combat-related infections in Ukraine: first nationwide surveillance, 2023-2024 [0.03%]
乌克兰作战相关感染临床分离株的抗菌药物耐药性监测（2023-2024年）首次全国调查
Ludmila Kasatkina,Ihnat Havrylov,Anzhela Sboieva et al.
Ludmila Kasatkina et al.
Antimicrobial resistance (AMR) is a critical global health threat, which reduces the effectiveness of treatment and drives higher morbidity, mortality, and costs. In Ukraine, the problem has been further aggravated by Russia's full-scale in...
Mapping the genomic landscape of antibiotic susceptiblity in Escherichia coli [0.03%]
抗生素敏感性的遗传图谱：以大肠杆菌为例
Sarah Bastkowski,A Keith Turner,Muhammad Yasir et al.
Sarah Bastkowski et al.
Antibiotic treatment failure is frequently driven by bacterial insusceptibility, yet understanding of the full repertoire of genes contributing to this in Gram-negative bacteria remains incomplete. We used TraDIS-Xpress, a high-density tran...
AMR in wild animals and plants: global trends and future priorities in wildlife-associated antimicrobial resistance research [0.03%]
野生动物中抗菌药物耐药性的全球趋势及未来研究重点
Holly J Tipper,Rachel A Payne,Isobel C Stanton et al.
Holly J Tipper et al.
Antimicrobial resistance (AMR) is a major global health concern, involving complex transmission pathways linking humans, domestic animals, wildlife, and the environment. Wild animals and plants can harbour and transmit AMR, while also servi...
Metagenomic profiling reveals shared resistome signatures between humans and pigs in Vietnamese smallholder farms [0.03%]
元基因组分析揭示了越南小型农场的人类和猪之间共享的抗性组特征
Le Thi Kieu Linh,Truong Nhat My,Nhat Thi Tran et al.
Le Thi Kieu Linh et al.
Antimicrobial resistance (AMR) is a global health concern, yet the extent of resistant genes and microbial exchange between humans and livestock in low- and middle-income countries remains underexplored. Vietnam, an AMR hotspot, was studied...
Exploiting DprE2 pathway redundancy to enhance potency and overcome resistance to pretomanid in Mycobacterium tuberculosis [0.03%]
利用DprE2途径的冗余性增强pretomanid对耐药结核分枝杆菌的活性
Kamel Djaout,Aurore Dreneau,Léo Faion et al.
Kamel Djaout et al.
Tuberculosis (TB), the deadliest infectious disease globally, still poses an enormous public health challenge exacerbated by the rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) M. tuberculosis strains. The bicyclic n...
Machine learning-based discovery of GW3965 as a therapeutic compound against invasive emm92-type group A Streptococcus [0.03%]
基于机器学习发现GW3965作为侵袭性emm92型A群链球菌感染的治疗化合物
Lillie M Powell,Megan E Grund,Wenxian Shi et al.
Lillie M Powell et al.
A multi-drug resistant emm92-type strain of group A Streptococcus (GAS) has emerged as an important causative agent of invasive infections-particularly affecting people who inject drugs-in the United States. To curtail this developing threa...