Seyed Arad Moghadasi,Rayhan G Biswas,Daniel A Harki et al.
Seyed Arad Moghadasi et al.
Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a robust cell-based assay is used to determine the relative potencies of nirmatrelvir, ensitrelvir, and FB20...
History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome [0.03%]
streptothricin类抗生素的历史及其耐药菌的发现被忽略了吗
Ezabelle Franck,Terence S Crofts
Ezabelle Franck
The streptothricin antibiotics were among the first antibiotics to be discovered from the environment and remain some of the most recovered antimicrobials in natural product screens. Increasing rates of antibiotic resistance and recognition...
Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduced susceptibility against 5-fluorocytosine [0.03%]
新型隐球菌嘧啶补救途径酶的基因突变导致其对氟胞嘧啶敏感性降低
Fatima Zohra Delma,Dong-Hoon Yang,Alfredo Cabrera-Orefice et al.
Fatima Zohra Delma et al.
Cryptococcal meningitis is a high-mortality infection. Adding 5-fluorocytosine (5-FC) to its treatment improves outcomes, but resistance to 5-FC presents a significant challenge. We conducted whole-genome sequencing on seven C. neoformans i...
Integration of vanHAX downstream of a ribosomal RNA operon restores vancomycin resistance in a susceptible Enterococcus faecium strain [0.03%]
万古霉素敏感肠球菌中vanHAX基因整合至核糖体RNA操纵子恢复耐药性
Ross S McInnes,Ann E Snaith,Steven J Dunn et al.
Ross S McInnes et al.
During the genomic characterisation of Enterococcus faecium strains (n = 39) collected in a haematology ward, we identified an isolate (OI25), which contained vanA-type vancomycin resistance genes but was phenotypically susceptible to vanco...
Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification [0.03%]
抗微生物肽 glatiramer acetate 咬合绿脓杆菌脂多糖以破坏膜而不改变脂多糖修饰
Ronan A Murphy,Jade Pizzato,Leah Cuthbertson et al.
Ronan A Murphy et al.
Antimicrobial peptides (AMPs) are key components of innate immunity across all domains of life. Natural and synthetic AMPs are receiving renewed attention in efforts to combat the antimicrobial resistance (AMR) crisis and the loss of antibi...
Alberto Hipólito,Lucía García-Pastor,Ester Vergara et al.
Alberto Hipólito et al.
Integrons have played a major role in the rise and spread of multidrug resistance in Gram-negative pathogens and are nowadays commonplace among clinical isolates. These platforms capture, stockpile, and modulate the expression of more than ...
Known mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci [0.03%]
已知机制无法解释非 aureus 葡萄球菌降低敏感性中的三分之一
Heather Felgate,Lisa C Crossman,Elizabeth Gray et al.
Heather Felgate et al.
Non-aureus staphylococci (NAS) are implicated in many healthcare-acquired infections and an understanding of the genetics of antimicrobial resistance is important in relation to both clinical intervention and the role of NAS as a reservoir ...
Non-antibiotic pharmaceuticals are toxic against Escherichia coli with no evolution of cross-resistance to antibiotics [0.03%]
非抗生素药物可毒杀大肠杆菌且不会产生交叉耐药性变异菌株
Rebecca J Hall,Ann E Snaith,Sarah J Element et al.
Rebecca J Hall et al.
Antimicrobial resistance can arise in the natural environment via prolonged exposure to the effluent released by manufacturing facilities. In addition to antibiotics, pharmaceutical plants also produce non-antibiotic pharmaceuticals, both t...
Jessica M A Blair
Jessica M A Blair
Bence Bognár,Réka Spohn,Viktória Lázár
Bence Bognár
While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination ther...