Identification and characterisation of two functional antibiotic MATE efflux pumps in the archaeon Halorubrum amylolyticum [0.03%]
盐杆菌属淀粉酶产生菌Halorubrum amylolyticum中两类功能型抗生素MATE外排泵的鉴定与表征
Asma A Fakhoury,Thomas P Thompson,Khondaker Miraz Rahman et al.
Asma A Fakhoury et al.
Multidrug efflux pumps have been found to play a crucial role in drug resistance in bacteria and eukaryotes. In this study, we investigated the presence of functional multidrug and toxic compound extrusion (MATE) efflux pumps, inferred from...
Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi [0.03%]
实验进化在病原真菌耐药性研究中的应用潜力建议综述
Stef Jacobs,Giorgio Boccarella,Pieter van den Berg et al.
Stef Jacobs et al.
Exploring the dynamics and molecular mechanisms of antimicrobial drug resistance provides critical insights for developing effective strategies to combat it. This review highlights the potential of experimental evolution methods to study re...
Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa [0.03%]
全球流行遗传学及KPC-33型碳青霉烯和阿维巴坦耐药绿脓杆菌的表征
Longjie Zhou,Jiayao Yao,Ying Zhang et al.
Longjie Zhou et al.
Ceftazidime-avibactam (CZA) is currently one of the last resorts used to treat infections caused by carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa. However, KPC variants have become the main mechanism mediating CZA resis...
Seyed Arad Moghadasi,Rayhan G Biswas,Daniel A Harki et al.
Seyed Arad Moghadasi et al.
Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a robust cell-based assay is used to determine the relative potencies of nirmatrelvir, ensitrelvir, and FB20...
History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome [0.03%]
streptothricin类抗生素的历史及其耐药菌的发现被忽略了吗
Ezabelle Franck,Terence S Crofts
Ezabelle Franck
The streptothricin antibiotics were among the first antibiotics to be discovered from the environment and remain some of the most recovered antimicrobials in natural product screens. Increasing rates of antibiotic resistance and recognition...
Genetic mutations in Cryptococcus neoformans pyrimidine salvage pathway enzymes contribute to reduced susceptibility against 5-fluorocytosine [0.03%]
新型隐球菌嘧啶补救途径酶的基因突变导致其对氟胞嘧啶敏感性降低
Fatima Zohra Delma,Dong-Hoon Yang,Alfredo Cabrera-Orefice et al.
Fatima Zohra Delma et al.
Cryptococcal meningitis is a high-mortality infection. Adding 5-fluorocytosine (5-FC) to its treatment improves outcomes, but resistance to 5-FC presents a significant challenge. We conducted whole-genome sequencing on seven C. neoformans i...
Integration of vanHAX downstream of a ribosomal RNA operon restores vancomycin resistance in a susceptible Enterococcus faecium strain [0.03%]
万古霉素敏感肠球菌中vanHAX基因整合至核糖体RNA操纵子恢复耐药性
Ross S McInnes,Ann E Snaith,Steven J Dunn et al.
Ross S McInnes et al.
During the genomic characterisation of Enterococcus faecium strains (n = 39) collected in a haematology ward, we identified an isolate (OI25), which contained vanA-type vancomycin resistance genes but was phenotypically susceptible to vanco...
Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification [0.03%]
抗微生物肽 glatiramer acetate 咬合绿脓杆菌脂多糖以破坏膜而不改变脂多糖修饰
Ronan A Murphy,Jade Pizzato,Leah Cuthbertson et al.
Ronan A Murphy et al.
Antimicrobial peptides (AMPs) are key components of innate immunity across all domains of life. Natural and synthetic AMPs are receiving renewed attention in efforts to combat the antimicrobial resistance (AMR) crisis and the loss of antibi...
Alberto Hipólito,Lucía García-Pastor,Ester Vergara et al.
Alberto Hipólito et al.
Integrons have played a major role in the rise and spread of multidrug resistance in Gram-negative pathogens and are nowadays commonplace among clinical isolates. These platforms capture, stockpile, and modulate the expression of more than ...
Known mechanisms cannot account for a third of reduced susceptibility in non-aureus staphylococci [0.03%]
已知机制无法解释非 aureus 葡萄球菌降低敏感性中的三分之一
Heather Felgate,Lisa C Crossman,Elizabeth Gray et al.
Heather Felgate et al.
Non-aureus staphylococci (NAS) are implicated in many healthcare-acquired infections and an understanding of the genetics of antimicrobial resistance is important in relation to both clinical intervention and the role of NAS as a reservoir ...