Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance [0.03%]
细菌异耐药的流行病学、机制及其临床影响
Linna Xu,Xiaofen Mo,Hui Zhang et al.
Linna Xu et al.
Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases. It is ...
Napawit Nonthakaew,Liam K R Sharkey,Sacha J Pidot
Napawit Nonthakaew
The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimic...
A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli [0.03%]
大肠杆菌多功能外膜通道蛋白TolC的历史回顾
Mallory Wright,Mandeep Kaur,Laura K Thompson et al.
Mallory Wright et al.
Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacterioph...
Assessment of tuberculosis drug efficacy using preclinical animal models and in vitro predictive techniques [0.03%]
基于临床前动物模型和体外预测技术的结核病药物疗效评估
Hazem F M Abdelaal,Bryan J Berube,Brendan K Podell et al.
Hazem F M Abdelaal et al.
Tuberculosis (TB) killed approximately 1.3 million people in 2022 and remains a leading cause of death from the bacteria Mycobacterium tuberculosis (M.tb); this number of deaths was surpassed only by COVID-19, caused by the SARS-CoV-2 virus...
Private and well drinking water are reservoirs for antimicrobial resistant bacteria [0.03%]
抗微生物药物耐药细菌的储藏库：私人和饮用水井都是潜在来源
Marwa Alawi,Cian Smyth,David Drissner et al.
Marwa Alawi et al.
Water quality testing does not recognise antimicrobial resistance (AMR) and is often limited to indicators of faecal contamination Escherichia coli and Enterococcus species. In Europe, data on AMR in drinking water is scarce. In Ireland, as...
Rebecca Hibbard,Marc Mendelson,Stephen W Page et al.
Rebecca Hibbard et al.
Antimicrobial stewardship (AMS) is a commonly advocated approach to address antimicrobial resistance. However, AMS is often defined in different ways depending on where it is applied, such that a range of definitions is now in use. These de...
Laura May Murray,April Hayes,Jason Snape et al.
Laura May Murray et al.
The environment is increasingly recognised as a hotspot for the selection and dissemination of antibiotic resistant bacteria and antibiotic resistance genes. These can be selected for by antibiotics and non-antibiotic agents (such as metals...
Identification and characterisation of two functional antibiotic MATE efflux pumps in the archaeon Halorubrum amylolyticum [0.03%]
盐杆菌属淀粉酶产生菌Halorubrum amylolyticum中两类功能型抗生素MATE外排泵的鉴定与表征
Asma A Fakhoury,Thomas P Thompson,Khondaker Miraz Rahman et al.
Asma A Fakhoury et al.
Multidrug efflux pumps have been found to play a crucial role in drug resistance in bacteria and eukaryotes. In this study, we investigated the presence of functional multidrug and toxic compound extrusion (MATE) efflux pumps, inferred from...
Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi [0.03%]
实验进化在病原真菌耐药性研究中的应用潜力建议综述
Stef Jacobs,Giorgio Boccarella,Pieter van den Berg et al.
Stef Jacobs et al.
Exploring the dynamics and molecular mechanisms of antimicrobial drug resistance provides critical insights for developing effective strategies to combat it. This review highlights the potential of experimental evolution methods to study re...
Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa [0.03%]
全球流行遗传学及KPC-33型碳青霉烯和阿维巴坦耐药绿脓杆菌的表征
Longjie Zhou,Jiayao Yao,Ying Zhang et al.
Longjie Zhou et al.
Ceftazidime-avibactam (CZA) is currently one of the last resorts used to treat infections caused by carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa. However, KPC variants have become the main mechanism mediating CZA resis...