An Australian perspective on clinical, economic and regulatory considerations in emerging nanoparticle therapies for infections [0.03%]
澳大利亚对感染新兴纳米粒子疗法的临床、经济和监管因素的考量观点
Benjamin W Muir,Jennifer A E Payne,Jennifer H Martin et al.
Benjamin W Muir et al.
Antimicrobial resistance (AMR) poses a growing global health threat. Nanomedicine, combined with drug repurposing, may help extend the effective lifespan of current and new antimicrobials. This review, presents an Australian perspective on ...
Genomic survey of multidrug resistant Salmonella enterica serovar Minnesota clones in chicken products [0.03%]
多药耐药沙门氏菌明尼苏达型基因组概览及其在鸡肉制品中的分布
Jiayi Huang,Khaloud O Alzahrani,Ge Zhou et al.
Jiayi Huang et al.
Salmonella enterica serovar Minnesota (S. Minnesota) is an emerging serovar that persists within poultry supply chains, potentially causing outbreaks in humans. Understanding its population genomics is crucial for designing preventive measu...
Genomic analysis of antimicrobial resistant Escherichia coli isolated from manure and manured agricultural grasslands [0.03%]
源自粪便和施肥草地的抗微生物药物耐药性大肠杆菌的基因组分析
C Tyrrell,C M Burgess,F P Brennan et al.
C Tyrrell et al.
Antimicrobial resistance (AMR) is a multifactorial issue involving an intertwining relationship between animals, humans and the environment. The environment can harbour Escherichia coli that are pathogenic or commensal. Escherichia coli is ...
Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance [0.03%]
细菌异耐药的流行病学、机制及其临床影响
Linna Xu,Xiaofen Mo,Hui Zhang et al.
Linna Xu et al.
Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases. It is ...
Napawit Nonthakaew,Liam K R Sharkey,Sacha J Pidot
Napawit Nonthakaew
The genus Nocardia comprises over 130 species of soil-dwelling actinomycetes, many of which are opportunistic pathogens. Beyond their pathogenicity, Nocardia exhibits significant biosynthetic potential, producing an array of diverse antimic...
A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli [0.03%]
大肠杆菌多功能外膜通道蛋白TolC的历史回顾
Mallory Wright,Mandeep Kaur,Laura K Thompson et al.
Mallory Wright et al.
Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacterioph...
Assessment of tuberculosis drug efficacy using preclinical animal models and in vitro predictive techniques [0.03%]
基于临床前动物模型和体外预测技术的结核病药物疗效评估
Hazem F M Abdelaal,Bryan J Berube,Brendan K Podell et al.
Hazem F M Abdelaal et al.
Tuberculosis (TB) killed approximately 1.3 million people in 2022 and remains a leading cause of death from the bacteria Mycobacterium tuberculosis (M.tb); this number of deaths was surpassed only by COVID-19, caused by the SARS-CoV-2 virus...
Private and well drinking water are reservoirs for antimicrobial resistant bacteria [0.03%]
抗微生物药物耐药细菌的储藏库：私人和饮用水井都是潜在来源
Marwa Alawi,Cian Smyth,David Drissner et al.
Marwa Alawi et al.
Water quality testing does not recognise antimicrobial resistance (AMR) and is often limited to indicators of faecal contamination Escherichia coli and Enterococcus species. In Europe, data on AMR in drinking water is scarce. In Ireland, as...
Rebecca Hibbard,Marc Mendelson,Stephen W Page et al.
Rebecca Hibbard et al.
Antimicrobial stewardship (AMS) is a commonly advocated approach to address antimicrobial resistance. However, AMS is often defined in different ways depending on where it is applied, such that a range of definitions is now in use. These de...
Laura May Murray,April Hayes,Jason Snape et al.
Laura May Murray et al.
The environment is increasingly recognised as a hotspot for the selection and dissemination of antibiotic resistant bacteria and antibiotic resistance genes. These can be selected for by antibiotics and non-antibiotic agents (such as metals...