Madeline Mei,Isaac Estrada,Stephen P Diggle et al.
Madeline Mei et al.
R-pyocins, bacteriocin-like proteins produced by Pseudomonas aeruginosa, present a promising alternative to phage therapy and/or adjunct to currently used antimicrobials in treating bacterial infections due to their targeted specificity, la...
Aspergillus fumigatus mitogenomes and their influence on azole-resistant and -susceptible populations [0.03%]
烟曲霉的线粒体基因组及其对azole类抗真菌药抵抗性和敏感性群体的影响
Endrews Delbaje,Laís Pontes,Johanna Rhodes et al.
Endrews Delbaje et al.
The role of the fungal mitochondria goes far beyond energy metabolism. The genomes of 318 Aspergillus fumigatus clinical and environmental isolates from different geographic origins were analyzed aiming to study the mitochondrial sequences ...
Advantages and limitations of large language models for antibiotic prescribing and antimicrobial stewardship [0.03%]
大型语言模型在抗生素处方和抗菌管理中的优势与限制
Daniele Roberto Giacobbe,Cristina Marelli,Bianca La Manna et al.
Daniele Roberto Giacobbe et al.
Antibiotic prescribing requires balancing optimal treatment for patients with reducing antimicrobial resistance. There is a lack of standardization in research on using large language models (LLMs) for supporting antibiotic prescribing, nec...
Emerging antimicrobial therapies for Gram-negative infections in human clinical use [0.03%]
用于人类临床使用的抗革兰氏阴性菌感染的新兴抗菌疗法
Sarah M Hickson,Emma L Ledger,Timothy J Wells
Sarah M Hickson
The growing problem of multi-drug resistance (MDR) is prevalent in Gram-negative infections, and the significant decline in antibiotic development poses a critical threat to global public health. Many emerging non-antibiotic therapies have ...
Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events [0.03%]
肠杆菌复杂群中由瞬时基因扩增事件变异引起的异质耐药性
Johannes Kupke,Julian Brombach,Yuwen Fang et al.
Johannes Kupke et al.
Heteroresistance (HR) in bacteria describes a subpopulational phenomenon of antibiotic resistant cells of a generally susceptible population. Here, we investigated the molecular mechanisms and phenotypic characteristics underlying HR to cef...
Rethinking the words hostspot reservoir and pristine in the environmental dimensions of antimicrobial resistance [0.03%]
从抗菌素耐药性的环境维度重新思考热点、储库和原始状态这些词汇
Richard Helliwell,Isabel Ewin,Alexander D Williams et al.
Richard Helliwell et al.
We assess three words commonly used to represent the environmental dimensions of antimicrobial resistance (AMR) - 'hotspot', 'reservoir' and 'pristine' - through two questions: how are these terms used in published research; and how do thes...
Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR [0.03%]
使用IDentif.AI-AMR进行鲍曼不动杆菌药物组合的快速优化
Kui You,Nurhidayah Binte Mohamed Yazid,Li Ming Chong et al.
Kui You et al.
Antimicrobial resistance (AMR) is an emerging threat to global public health. Specifically, Acinetobacter baumannii (A. baumannii), one of the main pathogens driving the rise of nosocomial infections, is a Gram-negative bacillus that displa...
An Australian perspective on clinical, economic and regulatory considerations in emerging nanoparticle therapies for infections [0.03%]
澳大利亚对感染新兴纳米粒子疗法的临床、经济和监管因素的考量观点
Benjamin W Muir,Jennifer A E Payne,Jennifer H Martin et al.
Benjamin W Muir et al.
Antimicrobial resistance (AMR) poses a growing global health threat. Nanomedicine, combined with drug repurposing, may help extend the effective lifespan of current and new antimicrobials. This review, presents an Australian perspective on ...
Genomic survey of multidrug resistant Salmonella enterica serovar Minnesota clones in chicken products [0.03%]
多药耐药沙门氏菌明尼苏达型基因组概览及其在鸡肉制品中的分布
Jiayi Huang,Khaloud O Alzahrani,Ge Zhou et al.
Jiayi Huang et al.
Salmonella enterica serovar Minnesota (S. Minnesota) is an emerging serovar that persists within poultry supply chains, potentially causing outbreaks in humans. Understanding its population genomics is crucial for designing preventive measu...
Genomic analysis of antimicrobial resistant Escherichia coli isolated from manure and manured agricultural grasslands [0.03%]
源自粪便和施肥草地的抗微生物药物耐药性大肠杆菌的基因组分析
C Tyrrell,C M Burgess,F P Brennan et al.
C Tyrrell et al.
Antimicrobial resistance (AMR) is a multifactorial issue involving an intertwining relationship between animals, humans and the environment. The environment can harbour Escherichia coli that are pathogenic or commensal. Escherichia coli is ...