Integrating socioeconomic deprivation indices and electronic health record data to predict antimicrobial resistance [0.03%]
整合社会经济剥夺指数和电子健康记录数据以预测抗菌素耐药性
Marlon I Diaz,Lauren N Cooper,John J Hanna et al.
Marlon I Diaz et al.
We developed machine learning models to predict the presence of AMR organisms in blood cultures obtained at the first patient encounter, offering a new and inspiring direction for antimicrobial resistance management. Three supervised machin...
Silvia T Cardona,A S M Zisanur Rahman,Julieta Novomisky Nechcoff
Silvia T Cardona
Antibiotics are essential to modern medicine, but multidrug-resistant (MDR) bacterial infections threaten their efficacy. Resistance evolution shortens antibiotic lifespans, limiting investment returns and slowing new approvals. Consequentl...
Autumn Arnold,Stewart McLellan,Jonathan M Stokes
Autumn Arnold
Antimicrobial resistance (AMR) is an urgent public health threat. Advancements in artificial intelligence (AI) and increases in computational power have resulted in the adoption of AI for biological tasks. This review explores the applicati...
Madeline Mei,Isaac Estrada,Stephen P Diggle et al.
Madeline Mei et al.
R-pyocins, bacteriocin-like proteins produced by Pseudomonas aeruginosa, present a promising alternative to phage therapy and/or adjunct to currently used antimicrobials in treating bacterial infections due to their targeted specificity, la...
Aspergillus fumigatus mitogenomes and their influence on azole-resistant and -susceptible populations [0.03%]
烟曲霉的线粒体基因组及其对azole类抗真菌药抵抗性和敏感性群体的影响
Endrews Delbaje,Laís Pontes,Johanna Rhodes et al.
Endrews Delbaje et al.
The role of the fungal mitochondria goes far beyond energy metabolism. The genomes of 318 Aspergillus fumigatus clinical and environmental isolates from different geographic origins were analyzed aiming to study the mitochondrial sequences ...
Advantages and limitations of large language models for antibiotic prescribing and antimicrobial stewardship [0.03%]
大型语言模型在抗生素处方和抗菌管理中的优势与限制
Daniele Roberto Giacobbe,Cristina Marelli,Bianca La Manna et al.
Daniele Roberto Giacobbe et al.
Antibiotic prescribing requires balancing optimal treatment for patients with reducing antimicrobial resistance. There is a lack of standardization in research on using large language models (LLMs) for supporting antibiotic prescribing, nec...
Emerging antimicrobial therapies for Gram-negative infections in human clinical use [0.03%]
用于人类临床使用的抗革兰氏阴性菌感染的新兴抗菌疗法
Sarah M Hickson,Emma L Ledger,Timothy J Wells
Sarah M Hickson
The growing problem of multi-drug resistance (MDR) is prevalent in Gram-negative infections, and the significant decline in antibiotic development poses a critical threat to global public health. Many emerging non-antibiotic therapies have ...
Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events [0.03%]
肠杆菌复杂群中由瞬时基因扩增事件变异引起的异质耐药性
Johannes Kupke,Julian Brombach,Yuwen Fang et al.
Johannes Kupke et al.
Heteroresistance (HR) in bacteria describes a subpopulational phenomenon of antibiotic resistant cells of a generally susceptible population. Here, we investigated the molecular mechanisms and phenotypic characteristics underlying HR to cef...
Rethinking the words hostspot reservoir and pristine in the environmental dimensions of antimicrobial resistance [0.03%]
从抗菌素耐药性的环境维度重新思考热点、储库和原始状态这些词汇
Richard Helliwell,Isabel Ewin,Alexander D Williams et al.
Richard Helliwell et al.
We assess three words commonly used to represent the environmental dimensions of antimicrobial resistance (AMR) - 'hotspot', 'reservoir' and 'pristine' - through two questions: how are these terms used in published research; and how do thes...
Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR [0.03%]
使用IDentif.AI-AMR进行鲍曼不动杆菌药物组合的快速优化
Kui You,Nurhidayah Binte Mohamed Yazid,Li Ming Chong et al.
Kui You et al.
Antimicrobial resistance (AMR) is an emerging threat to global public health. Specifically, Acinetobacter baumannii (A. baumannii), one of the main pathogens driving the rise of nosocomial infections, is a Gram-negative bacillus that displa...