Developing the trehalose biosynthesis pathway as an antifungal drug target [0.03%]
开发海藻糖生物合成途径作为抗真菌药物靶点
Erica J Washington
Erica J Washington
Invasive fungal infections are responsible for millions of deaths worldwide each year. Therefore, focusing on innovative approaches to developing therapeutics that target fungal pathogens is critical. Here, we discuss targeting the fungal t...
Design, synthesis and optimization of TarO inhibitors as multifunctional antibiotics against Methicillin-resistant Staphylococcus aureus [0.03%]
设计、合成及优化万古霉素耐药肠球菌多功能抗生素TarO抑制剂
Yuanchen Zhong,Feifei Chen,Dianyan Chen et al.
Yuanchen Zhong et al.
UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) has been found to simultaneously contribute to β-lactam resistance and virulence of Methicillin-resistant Staphylococcus aureus (MRSA). However, op...
Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals [0.03%]
针对真菌脂质合成的抗真菌药物开发及协同增效当代抗真菌药物作用机制研究
Cecilia Gutierrez-Perez,Robert A Cramer
Cecilia Gutierrez-Perez
Two of the three most commonly used classes of antifungal drugs target the fungal membrane through perturbation of sterol biosynthesis or function. In addition to these triazole and polyene antifungals, recent research is identifying new an...
Aula Abbara,Clare Shortall,Richard Sullivan et al.
Aula Abbara et al.
The compounded impacts of conflicts, natural disasters and climate change increasingly fuel the development and spread of drug-resistant organisms while weakening mitigation efforts through failed governance and health system disruptions. T...
Importance of diversity and representation in science: benefits towards strengthening our response to global challenges [0.03%]
科学多样性及代表性的重要性：增强我们应对全球挑战的响应能力益处多
Blanca M Perez-Sepulveda,Edward Cunningham-Oakes,Emma V Waters
Blanca M Perez-Sepulveda
Niilo Kaldalu,Normunds Bērziņš,Stina Berglund Fick et al.
Niilo Kaldalu et al.
Slow- and non-growing bacterial populations, along with intracellular pathogens, often evade standard antibacterial treatments and are linked to persistent and recurrent infections. This necessitates the development of therapies specificall...
Metabolic state-driven nutrient-based approach to combat bacterial antibiotic resistance [0.03%]
代谢状态驱动的营养抗性防治细菌抗生素抵抗性方法
Bo Peng,Hui Li,Xuan-Xian Peng
Bo Peng
To combat antibiotic resistance, one innovative approach, known as the metabolic state-driven approach, exploits the fact that exogenous nutrient metabolites can stimulate uptake of antibiotics. The most effective nutrient metabolites are i...
Repurposing antimicrobials with ultrasound-triggered nanoscale systems for targeted biofilm drug delivery [0.03%]
用于生物膜药物输送的超声波触发纳米级系统的抗菌再利用
Victor Choi,Dario Carugo,Eleanor Stride
Victor Choi
Chronic infections represent a major clinical challenge due to the enhanced antimicrobial tolerance of biofilm-dwelling bacteria. To address this challenge, an ultrasound-responsive nanoscale drug delivery platform (nanodroplets) is present...
Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli [0.03%]
评估金霉素在出芽致病性大肠杆菌模型中的保护作用
Rebecca E McHugh,Liam M Rooney,David R Mark et al.
Rebecca E McHugh et al.
Shiga Toxin-Producing E. coli (STEC) are a group of acute small intestine pathogens responsible for foodborne outbreaks of bloody diarrhoea. The expression of Shiga toxins (Stx) carried by STEC can initiate Haemolytic Uremic Syndrome (HUS),...
Exploiting social traits for clinical applications in bacteria and viruses [0.03%]
利用细菌和病毒的社会特性进行临床应用
Ashleigh S Griffin,Asher Leeks
Ashleigh S Griffin
Despite generating a great deal of interest in the form of review papers, progress in exploiting social dynamics for treatment strategies against bacterial infection has made limited progress since it was suggested twenty years ago. In cont...