A three-dimensional high throughput assay identifies novel antibacterial molecules with activity against intracellular Shigella [0.03%]
一种三维高通量检测方法鉴定出对侵入性志贺氏菌有活性的新型抗菌分子
Voong Vinh Phat,Andrew Shih Teong Lim,Cristina De Cozar-Gallardo et al.
Voong Vinh Phat et al.
The Gram-negative bacterial species Shigella is the second leading cause of diarrhea among children in low and middle-income countries (LMICs) and is a World Health Organization (WHO) priority pathogen. Shigella infections are becoming incr...
Reviewing the complexities of bacterial biocide susceptibility and in vitro biocide adaptation methodologies [0.03%]
细菌抗生物质敏感性和体外抗菌素适应方法的复杂性综述
Peter O&#x;Reilly,Genevieve Loiselle,Ryan Darragh et al.
Peter O&#x;Reilly et al.
Decreased bacterial susceptibility to biocides raises concerns due to their influences on antibiotic resistance. The lack of standardized breakpoints, established methods, and consistent terminology complicates this research. This review su...
Author Correction: Rethinking the words hostspot reservoir and pristine in the environmental dimensions of antimicrobial resistance [0.03%]
作者更正：从环境维度重新考虑抗微生物药物耐药性的热点、储存库和原始状态等词语
Richard Helliwell,Isabel Ewin,Alexander D Williams et al.
Richard Helliwell et al.
Published Erratum
npj antimicrobials and resistance. 2025 May 13;3(1):38. DOI:10.1038/s44259-025-00114-2 2025
Evolution of an extensively antibiotic resistant sublineage of lineage 1 of GC1 Acinetobacter baumannii [0.03%]
GC1鲍曼不动杆菌谱系1耐药亚系的进化历程研究进展
Christopher J Harmer,Ting L Luo,Francois Lebreton et al.
Christopher J Harmer et al.
The multiply antibiotic-resistant lineage 1 of Acinetobacter baumannii global clone 1 (GC1) emerged in the 1970s, and subsequently more extensively resistant sublineages have emerged. Here, we examined the evolution of the extensively resis...
Tools and challenges in the use of routine clinical data for antimicrobial resistance surveillance [0.03%]
用于抗菌药物耐药性监测的常规临床数据的应用工具及挑战
Kathryn E Holt,Megan E Carey,Clare Chandler et al.
Kathryn E Holt et al.
Routine clinical microbiology data are widely used for antimicrobial resistance (AMR) surveillance, but data availability and quality vary. In this Perspective, we explore the technical challenges of utilising routine data to inform action ...
Genome wide analyses reveal the role of mutator phenotypes in Mycobacterium tuberculosis drug resistance emergence [0.03%]
全基因组分析揭示了突变表型在结核分枝杆菌耐药性产生中的作用
R Zein-Eddine,A Le Meur,S Skouloubris et al.
R Zein-Eddine et al.
Antimicrobial combination therapy is widely used to combat Mycobacterium tuberculosis (Mtb), yet resistance rates continue to rise. Mutator strains, with defects in DNA repair genes, drive resistance in other bacterial infections, but their...
Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae [0.03%]
肠杆菌科的抗微生物药物耐药性和疫苗（包括肠外致病性大肠埃希氏菌和肺炎克雷伯菌）
Adriana Cabrera,Emily Mason,Liam P Mullins et al.
Adriana Cabrera et al.
Antimicrobial-resistant Enterobacteriaceae are increasingly a clinical challenge. In particular, extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae threaten public health. Vaccination presents a long-term strategy to redu...
Emergence of transferable daptomycin resistance in Gram-positive bacteria [0.03%]
万古霉素耐药阳性菌中可转移的达托霉素抗性的产生
Tessa Marciniak,Lukas Kirchner,Silver A Wolf et al.
Tessa Marciniak et al.
Daptomycin (DAP) is a last-resort antibiotic to treat infections by multiresistant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. DAP resistance and clinical treat...
Leveraging the microbiome to combat antibiotic resistant gynecological infections [0.03%]
利用微生物组对抗抗生素抗性妇科感染
Tanya Kumar,Aryak Rekhi,Yumie Lee et al.
Tanya Kumar et al.
The vaginal resistome can be considered a collection of the resistant determinants in the vaginal microbiome. Here we review the vaginal resistome including the microbes and resistant genes harbored in common gynecological infections, vagin...
Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolates [0.03%]
耐棘白菌素白色假丝酵母菌株间FKS1和FKS2基因的热点基因转换现象
Christopher Zajac,Nancy E Scott,Susan Kline et al.
Christopher Zajac et al.
Candida glabrata (Nakaseomyces glabratus) is the most common cause of drug-resistant candidemia and is associated with a high mortality rate. Only a few mechanisms of drug resistance are known in C. glabrata, predominantly involving recurre...