A review of natural products as a source of next-generation drugs against apicomplexan parasites [0.03%]
天然产物作为下一代阿米巴原虫药物来源的研究进展综述
Emma Y Mao,Stephen W Page,Brad E Sleebs et al.
Emma Y Mao et al.
Despite the substantial global health and economic burden of apicomplexan parasites in humans and livestock, treatment options remain limited. Natural products have long played an important role in combating these diseases, offering diverse...
Coevolutionary history of predation constrains the evolvability of antibiotic resistance in prey bacteria [0.03%]
捕食者与猎物间协同进化的历史限制了猎菌的抗生素抗性演化能力
Saheli Saha,Sneha Sureshkumar,Vaibhav Sharma et al.
Saheli Saha et al.
Understanding how the historical contingency of biotic interactions shapes the evolvability of bacterial populations is imperative for the predictability of the eco-evolutionary dynamics of microbial communities. While microbial predators l...
Emma R Holden,Muhammad Yasir,A Keith Turner et al.
Emma R Holden et al.
Piperacillin-Tazobactam is a β-lactam/β-lactamase inhibitor combination that is amongst the most prescribed antimicrobials in hospital medicine. Piperacillin is inactivated by many common beta-lactamases, but tazobactam inhibits these, al...
Mark A T Blaskovich,Matthew A Cooper
Mark A T Blaskovich
After decades of neglect and a decline in antibiotic research and development, we are now finally witnessing the advent of new funding programs dedicated to new therapies. In addition to traditional new chemical entities that directly kill ...
Laurence Couture,Fabrice Jean-Pierre,Jean-Philippe Côté
Laurence Couture
The lack of novel antimicrobial compounds in the development pipeline cries for innovative approaches regarding their discovery. In this Perspective, we discuss how microbial interactions play a significant role in shifting a pathogen's res...
Cross resistance emergence to polymyxins in Acinetobacter baumannii exposed in vitro to an antimicrobial peptide [0.03%]
体外暴露于抗菌肽后产生对多黏菌素耐药的醋酸钙不动杆菌
Emily Ritz,Tiffany Rossel,Nicolas Jacquier
Emily Ritz
Multidrug-resistant bacteria are a growing public health concern. Antimicrobial peptides (AMPs) are proposed alternatives to classical antibiotics towards infections caused by resistant bacteria. TAT-RasGAP317-326 is an AMP able to target G...
Bradley W M Cook,Alexander P Hynes
Bradley W M Cook
One of the biggest challenges in phage therapy is selecting the 'right' phage. What constitutes a 'good' phage is unclear, but regulators are converging on exclusion criteria for 'bad' phages. Here, we examine three commonly applied criteri...
Cytomegalovirus infection and drug resistance emergence during letermovir salvage therapy in a pediatric SCID patient [0.03%]
Letermovir挽救治疗下儿科SCID患者巨细胞病毒感染及药物耐药性产生
Fien Horsten,Sarah Gillemot,Pierluigi Calò et al.
Fien Horsten et al.
Cytomegalovirus (CMV) infection is a common complication in newborns with severe combined immunodeficiency (SCID). Prolonged antiviral treatment in immunocompromised patients increases the risk of the emergence of drug resistance. We analyz...
Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing [0.03%]
宿主微环境和细菌生活方式对抗微生物敏感性的影响及其对易感性检测的启示
Ramon Garcia-Maset,Victoria Chu,Nicholas Yuen et al.
Ramon Garcia-Maset et al.
Bacterial infections remain a major global health issue, with antimicrobial resistance (AMR) worsening the crisis. However, treatment failure can occur even when bacteria show antibiotic susceptibility in diagnostic tests. We explore factor...
Small-molecule screen in C. elegans identifies benzenesulfonamides as inhibitors of microsporidia spores [0.03%]
微丝菌孢子抑制剂苯磺酰胺类化合物的筛选与鉴定
Qingyuan Huang,Haiyi Jiang,Junhong Wei et al.
Qingyuan Huang et al.
Microsporidia, a large group of fungal-related intracellular parasites, infect several economically significant animals, leading to substantial economic losses. As currently available anti-microsporidia therapies are either ineffective or c...