Claire E Stevens,Ashley T Deventer,Joanne K Hobbs
Claire E Stevens
Metabolism plays a key role in the three antibiotic evasion strategies used by bacteria: tolerance, persistence and resistance. Modulation of purine metabolism is emerging as a common, and clinically relevant, contributor to tolerant and re...
The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis [0.03%]
帕金森药物苯海索具备针对结核分枝杆菌的宿主定向抗菌活性该活性依赖组胺受体1
Henok A Sahile,Matthew Christofferson,Morgan A Alford et al.
Henok A Sahile et al.
Intracellular pathogens such as Mycobacterium tuberculosis (Mtb) evade host defence mechanisms to infect and survive within host cells. Host-directed therapy (HDT) offers a promising alternative to antibiotics and may overcome antimicrobial...
The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens [0.03%]
医院下水道微生物群作为传播耐药基因到条件致病菌的熔炉
Gregory E McCallum,James P J Hall
Gregory E McCallum
The hospital sink drain microbiome can harbour opportunistic pathogens and antimicrobial resistance genes (ARGs). Aspects of this habitat, such as exposure to disinfectants, antibiotics, nutrients, and body fluids could exacerbate horizonta...
Inter- and intra-bacterial strain diversity remains the "elephant in the (living) room" [0.03%]
菌株多样性仍是我们忽视的“房间里的大象”
Adam Valcek,Carsten Kröger,Rubén de Dios et al.
Adam Valcek et al.
Acinetobacter baumannii is an opportunistic Gram-negative bacterial pathogen responsible for severe nosocomial infections worldwide. Resistance to last-resort antibiotics causes A. baumannii to be ranked as a top priority for the research a...
Pan-genus analysis and typing of antimicrobial resistance plasmids in Acinetobacter [0.03%]
泛属分析和表型测定阿氏菌耐药质粒
Liam A Tobin,Margaret M C Lam,Mehrad Hamidian
Liam A Tobin
Plasmids play a central role in horizontal gene transfer and bacterial adaptation, especially in the context of antimicrobial resistance (AMR) among opportunistic pathogens. Some members of the genus Acinetobacter are known for their role i...
Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins [0.03%]
细菌actifensin与真核生物defensin间的跨王国机制保守性
Ivan Sugrue,Carolin Ade,Paula M O&#x;Connor et al.
Ivan Sugrue et al.
Antimicrobial peptides are defense molecules found across all domains of life holding promise for developing therapies against drug-resistant pathogens. Actifensin, from Actinomyces ruminicola DPC7226, exhibits potent activity against gram-...
Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia [0.03%]
哥伦比亚各地医院肺炎克雷伯氏菌的流行遗传学特征
Victor A Medina,Angela S García-Vega,Fernando Rodríguez et al.
Victor A Medina et al.
Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a pros...
Citywide metagenomic surveillance of food centres reveals local microbial signatures and antibiotic resistance gene enrichment [0.03%]
城市范围内的食品中心宏基因组监测揭示了地方微生物特征和抗生素抗性基因富集
Jonathan J Y Teo,Eliza Xin Pei Ho,Amanda Hui Qi Ng et al.
Jonathan J Y Teo et al.
The distribution of microorganisms in built environments with high human traffic, such as food centres, can potentially have a significant impact on public health, particularly in the context of increasing worldwide incidence of food and fo...
Enhanced resistance of metal sequestering agents by reconfiguration of the Staphylococcus aureus cell wall [0.03%]
金黄色葡萄球菌细胞壁重构可增强金属螯合剂的抗菌效果
Joy R Paterson,Joshua M Wadsworth,Rebecca J Lee et al.
Joy R Paterson et al.
Chelators possess antibacterial properties linked to metal sequestration, simulating the action of nutritional immunity in preventing infection. To gain further insight into bacterial adaptation to metal restriction, we isolated mutants of ...
Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica [0.03%]
哥斯达黎加两种树懒的生态环境相互作用塑造了其大肠杆菌种群和耐药基因图谱
Cristina Calvo-Fernandez,Marta M Dolcet-Negre,Barbara Martin-Maldonado et al.
Cristina Calvo-Fernandez et al.
Antimicrobial resistance (AMR) is a global health concern, with natural ecosystems acting as reservoirs for resistant bacteria. We assessed AMR in Escherichia coli isolated from two wild sloth species in Costa Rica. E. coli from two-toed sl...