Proteomic and metabolomic responses of priority bacterial pathogens to subinhibitory concentration of antibiotics [0.03%]
重点细菌病原体对亚抑菌浓度抗生素的蛋白质组和代谢组响应
Monika Subanovic,Dean Frawley,Ciara Tierney et al.
Monika Subanovic et al.
This study employed a comprehensive proteomic and metabolomic analysis to characterize adaptive cellular mechanisms of priority pathogens-Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium, and Staphylococcus aureus-under sub-inh...
Biosynthetic ε-poly-L-lysine for the treatment of extensively- and pan-drug-resistant Pseudomonas aeruginosa [0.03%]
生物合成ε-聚-L-赖氨酸治疗广泛和全耐药铜绿假单胞菌
Darren Shu Jeng Ting,Thet Tun Aung,Venkatesh Mayandi et al.
Darren Shu Jeng Ting et al.
Pseudomonas aeruginosa (PA) represents a major cause of antimicrobial resistance-related morbidity and mortality. The recent emergence of highly fatal infections, caused by carbapenem-resistant PA, has called for novel antimicrobial therapi...
Communities of plasmids as strategies for antimicrobial resistance gene survival in wastewater treatment plant effluent [0.03%]
污水处理厂出水中抗微生物药物基因存活的质粒类群研究
Cian Smyth,Robert J Leigh,Thi Thuy Do et al.
Cian Smyth et al.
Plasmids facilitate antimicrobial resistance (AMR) gene spread via horizontal gene transfer, yet the mobility of genes in wastewater treatment plant (WWTP) resistomes remains unclear. We sequenced 173 circularised plasmids transferred from ...
Carmen Li,Serkan Sayin,Ethan Hau Chian Chang et al.
Carmen Li et al.
Studying how antibacterials operate at subinhibitory concentrations reveals how they impede normal growth. While previous works demonstrated drugs can impact multiple aspects of growth, such as prolonging the doubling time or reducing the m...
Mitigating antimicrobial resistance by innovative solutions in AI (MARISA): a modified James Lind Alliance analysis [0.03%]
利用人工智能创新解决方案减轻抗菌素耐药性（MARISA）：詹姆斯林联盟分析法的改良方法
William J Waldock,Hannah Thould,Leonid Chindelevitch et al.
William J Waldock et al.
Antimicrobial resistance (AMR) is a critical global health threat and artificial intelligence (AI) presents new opportunities for our response. However, research priorities at the AI-AMR intersection remain undefined. This study aimed to id...
Pharmacokinetic and pharmacodynamic studies of injectable nocathiacin as a novel antibacterial agent [0.03%]
注射用诺卡匹珊的药代动力学和药效学研究
Xisheng Xiong,Junjian Qian,Lang Wang et al.
Xisheng Xiong et al.
The extreme hydrophobicity of nocathiacin, a potent thiopeptide antibiotic against multidrug-resistant (MDR) Gram-positive pathogens, has limited its clinical development. This study formulated an injectable lyophilized nocathiacin with enh...
The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli [0.03%]
常用非抗生素药物对大肠埃希菌耐药性发展的影响
Hanbiao Chen,Sylvia A Sapula,John Turnidge et al.
Hanbiao Chen et al.
Antimicrobial resistance (AMR) poses a global threat to public health. While antibiotic overuse is a primary driver, emerging evidence suggests that non-antibiotic medications (NAMs) may also contribute. This concern is particularly relevan...
Identification and antimicrobial resistance profiling of Pseudomonas aeruginosa using multi-excitation Raman spectroscopy and computational analytics [0.03%]
基于多激发拉曼光谱与计算分析的铜绿假单胞菌鉴定及其耐药表型检测
Callum Highmore,Niall Hanrahan,Yoshiki Cook et al.
Callum Highmore et al.
Antimicrobial resistance (AMR) poses a global healthcare challenge, where overprescription of antibiotics contributes to its prevalence. We have developed a rapid multi-excitation Raman spectroscopy methodology (MX-Raman) that outperforms c...
Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance [0.03%]
质粒拷贝数在细菌病原性和抗生素抗性中的调节作用
Helen Wang,Enrique Joffré
Helen Wang
Plasmid copy number (PCN), the average number of plasmids per bacterial cell, links gene dosage to key traits such as host fitness, virulence, antibiotic resistance and evolutionary potential. Although often viewed as static, PCN is a dynam...
A mixed methods evaluation of an antimicrobial prescribing clinical decision support system app [0.03%]
抗菌药物处方临床决策支持系统应用的混合方法评价
William J Waldock,Mark Gilchrist,Hutan Ashrafian et al.
William J Waldock et al.
This study evaluated how the usability and accessibility of a digital antimicrobial prescribing app influences clinical decision-making. Using a convergent parallel mixed methods design, the study assessed app usage patterns with surveys an...