Lipopolysaccharide clustering in colistin persistent and resistant bacteria [0.03%]
多黏菌素耐受和耐药细菌中脂多糖的聚集现象
Fengyi Wang,George Merces,Dominic Alderson et al.
Fengyi Wang et al.
Polymyxin antibiotics target lipopolysaccharides (LPS) in Gram-negative bacteria, but persistence and mcr-mediated resistance increasingly compromise their therapeutic efficacy. Here, we use super-resolution localisation microscopy to inves...
Azole fungicides and Aspergillus resistance, five EU agency report highlights the problem for the first time using a One Health approach [0.03%]
唑类杀菌剂与曲霉菌抗性问题首次被欧盟机构报告以“同一健康”方法强调指出
Michaela Lackner,Ana Alastruey-Izquierdo,Darius P H Armstrong-James et al.
Michaela Lackner et al.
Environmental hazards from pollution of antibiotics and resistance-driving chemicals in an urban river network from Malawi [0.03%]
马拉维城市河流网络中抗生素和促进抗性化学物质污染带来的环境危害
Derek Cocker,Taonga Mwapasa,Roman Grabic et al.
Derek Cocker et al.
African communities have a high prevalence of antimicrobial-resistant bacterial carriage, alongside high levels of antibiotic usage and environmental pollution. Limited access to water, sanitation and hygiene infrastructure and wastewater t...
The butterfly effect: collateral damage and impacts of antimicrobial strategies on the oral microbiome [0.03%]
蝴蝶效应：抗菌策略对口腔微生物群的附带损害及其影响
Jason L Brown,William Johnston,Mark C Butcher et al.
Jason L Brown et al.
The oral cavity is a complex environment hosting diverse microbial biofilms on different surfaces, all immersed in saliva that enables recolonisation and spread. These microbial populations fluctuate with diet, hygiene, antimicrobials, and ...
Resistance of ERG24 sterol C-14 reductase to heterocyclic amine antifungals [0.03%]
ERG24固醇C-14还原酶对异环胺抗真菌药的耐药性
Corinne J Arnold,Laetitia Chartrain,David M Lawson et al.
Corinne J Arnold et al.
There is an urgent need for a wider range of antifungals in medicine and agriculture and for their dual use in both contexts to be minimised. As new modes of action may incur unforeseen side-effects, existing groups of antifungals which hav...
Relating antimicrobial use to wastewater resistance gene patterns via metagenomic analysis of two neighboring treatment plants circa the COVID-19 pandemic [0.03%]
通过两个相邻污水处理厂的元基因组分析将抗菌药物使用与废水中的耐药基因模式联系起来（新冠疫情期间）
Ayella Maile-Moskowitz,Connor L Brown,Monjura Afrin Rumi et al.
Ayella Maile-Moskowitz et al.
Minimizing antimicrobial use is a recommended strategy to reduce the evolution and spread of antibiotic resistance; however, efficacy is elusive to measure. Wastewater-based surveillance provides a promising means to relate trends in microb...
Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment [0.03%]
抗生素抗性基因传播与环境监测和风险评估的整合研究进展
Uli Klümper,Peiju Fang,Bing Li et al.
Uli Klümper et al.
Antibiotic resistance gene (ARG) mobility plays a crucial role in the spread of antimicrobial resistance across One Health settings. Current environmental surveillance often overlooks the significance of ARG mobility, limiting risk assessme...
Proteomic and metabolomic responses of priority bacterial pathogens to subinhibitory concentration of antibiotics [0.03%]
重点细菌病原体对亚抑菌浓度抗生素的蛋白质组和代谢组响应
Monika Subanovic,Dean Frawley,Ciara Tierney et al.
Monika Subanovic et al.
This study employed a comprehensive proteomic and metabolomic analysis to characterize adaptive cellular mechanisms of priority pathogens-Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium, and Staphylococcus aureus-under sub-inh...
Biosynthetic ε-poly-L-lysine for the treatment of extensively- and pan-drug-resistant Pseudomonas aeruginosa [0.03%]
生物合成ε-聚-L-赖氨酸治疗广泛和全耐药铜绿假单胞菌
Darren Shu Jeng Ting,Thet Tun Aung,Venkatesh Mayandi et al.
Darren Shu Jeng Ting et al.
Pseudomonas aeruginosa (PA) represents a major cause of antimicrobial resistance-related morbidity and mortality. The recent emergence of highly fatal infections, caused by carbapenem-resistant PA, has called for novel antimicrobial therapi...
Communities of plasmids as strategies for antimicrobial resistance gene survival in wastewater treatment plant effluent [0.03%]
污水处理厂出水中抗微生物药物基因存活的质粒类群研究
Cian Smyth,Robert J Leigh,Thi Thuy Do et al.
Cian Smyth et al.
Plasmids facilitate antimicrobial resistance (AMR) gene spread via horizontal gene transfer, yet the mobility of genes in wastewater treatment plant (WWTP) resistomes remains unclear. We sequenced 173 circularised plasmids transferred from ...