Bacterial therapies at the interface of synthetic biology and nanomedicine [0.03%]
合成生物学和纳米医学接口处的细菌疗法
Jaeseung Hahn,Suwan Ding,Jongwon Im et al.
Jaeseung Hahn et al.
Bacteria are emerging as living drugs to treat a broad range of disease indications. However, the inherent advantages of these replicating and immunostimulatory therapies also carry the potential for toxicity. Advances in synthetic biology ...
Modelling patient drug exposure profiles in vitro to narrow the valley of death [0.03%]
体外模拟患者药物暴露谱型以缩小死亡谷现象发生的范围
Catherine S Leasure,Gregor Neuert
Catherine S Leasure
Zhiye Guo,Jian Liu,Yanli Wang et al.
Zhiye Guo et al.
Denoising diffusion models embody a type of generative artificial intelligence that can be applied in computer vision, natural language processing and bioinformatics. In this Review, we introduce the key concepts and theoretical foundations...
Targeted modulation of immune cells and tissues using engineered biomaterials [0.03%]
利用工程生物材料靶向调节免疫细胞和组织
Parisa Yousefpour,Kaiyuan Ni,Darrell J Irvine
Parisa Yousefpour
Therapies modulating the immune system offer the prospect of treating a wide range of conditions including infectious diseases, cancer and autoimmunity. Biomaterials can promote specific targeting of immune cell subsets in peripheral or lym...
W Taylor Kimberly,Annabel J Sorby-Adams,Andrew G Webb et al.
W Taylor Kimberly et al.
The advent of portable, low-field MRI (LF-MRI) heralds new opportunities in neuroimaging. Low power requirements and transportability have enabled scanning outside the controlled environment of a conventional MRI suite, enhancing access to ...
Kaiyue Zhang,Ke Cheng
Kaiyue Zhang
Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar cl...
Christopher M Jewell,Miloš D Miljković,Robert S Oakes
Christopher M Jewell
Scientific bias originates from both researchers and techniques. Evidence-based strategies to mitigate this bias include the assembly of diverse teams, development of rigorous experimental designs, and use of unbiased analytical techniques....
Anna Loewa,James J Feng,Sarah Hedtrich
Anna Loewa
Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process. Major drivers for this transition are the limitations...
Cosimo Ligorio,Alvaro Mata
Cosimo Ligorio
The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide epitopes can be incorporated in biomaterials to serve as fun...
Analytical device miniaturization for the detection of circulating biomarkers [0.03%]
用于循环生物标志物检测的分析设备微缩化
Auginia Natalia,Li Zhang,Noah R Sundah et al.
Auginia Natalia et al.
Diverse (sub)cellular materials are secreted by cells into the systemic circulation at different stages of disease progression. These circulating biomarkers include whole cells, such as circulating tumour cells, subcellular extracellular ve...