Chad A Mirkin,Milan Mrksich,Natalie Artzi
Chad A Mirkin
The lack of structural definition in nanomedicines limits therapeutic efficacy and complicates regulatory approval. Here, we emphasize that defining, designing and optimizing the structures of nanomedicine are critical to developing effecti...
Joshua A Homer,Robert M Johnson,Rebecca A Koelln et al.
Joshua A Homer et al.
Multidrug-resistant bacteria, especially those that defy even last-resort antibiotics, are causing a global health crisis fueled by antibiotic overuse and misuse as well as the lack of new antibiotic development. Multidrug-resistant bacteri...
Ali Shakeri-Zadeh,Jeff W M Bulte
Ali Shakeri-Zadeh
Magnetic nanoparticles, including those formed of superparamagnetic iron oxides (SPIOs), are employed in various magnetic imaging and therapeutic techniques. In vivo imaging techniques based on the detection of magnetic nanoparticles inside...
Girgis Obaid,Jonathan P Celli,Mans Broekgaarden et al.
Girgis Obaid et al.
Photodynamic therapy (PDT) is a photochemistry-based treatment approach that relies on the activation of photosensitizers by light to locally generate reactive oxygen species that induce cellular cytotoxicity, in particular for the treatmen...
Fangping Wan,Felix Wong,James J Collins et al.
Fangping Wan et al.
Artificial intelligence (AI) and machine learning (ML) models are being deployed in many domains of society and have recently reached the field of drug discovery. Given the increasing prevalence of antimicrobial resistance, as well as the c...
Anthony O Omole,Zhongchao Zhao,Sabrina Chang-Liao et al.
Anthony O Omole et al.
Viruses can be designed to be tools and carrier vehicles for intratumoural immunotherapy. Their nanometre-scale size and shape allow for functionalization with or encapsulation of medical cargoes and tissue-specific ligands. Importantly, im...
Shamik Mascharak,Jason L Guo,Michelle Griffin et al.
Shamik Mascharak et al.
Few efficacious therapies exist for the treatment of fibrotic diseases, such as skin scarring, liver cirrhosis and pulmonary fibrosis, which is related to our limited understanding of the fundamental causes and mechanisms of fibrosis. Mecha...
Nanoparticle Delivery to Tumours: From EPR and ATR Mechanisms to Clinical Impact [0.03%]
纳米颗粒向肿瘤传递：从EPR和ATR机制到临床影响
Anshuman Dasgupta,Alexandros Marios Sofias,Fabian Kiessling et al.
Anshuman Dasgupta et al.
New insights into active versus passive nanoparticle tumour entry and exit mechanisms are enriching the understanding of tumour-targeted drug delivery. Here, we align the principles of the enhanced permeability and retention (EPR) and activ...
Optical imaging for screening and early cancer diagnosis in low-resource settings [0.03%]
低资源环境下光学影像筛查及早期癌症诊断技术
Rebecca Richards-Kortum,Cesaltina Lorenzoni,Vanderlei S Bagnato et al.
Rebecca Richards-Kortum et al.
Low-cost optical imaging technologies have the potential to reduce inequalities in healthcare by improving the detection of pre-cancer or early cancer and enabling more effective and less invasive treatment. In this Review, we summarise tec...
Yingqiao Wang,Raghav Garg,Devora Cohen-Karni et al.
Yingqiao Wang et al.
Modulating neural electrophysiology with high precision is essential for understanding neural communication and for the diagnosis and treatment of neural disorders. Photothermal modulation offers a remote and non-genetic method for neural m...