Kiana Aran,Brett R Goldsmith
Kiana Aran
Combining the precision of CRISPR's DNA searching ability with the speed and scalability of electronics, we have developed an 'electronic DNA search engine', called a CRISPR-Chip, which not only enables DNA detection without amplification, ...
Emilio Di Ianni,Wataru Obuchi,Koen Breyne et al.
Emilio Di Ianni et al.
Gene therapy has brought hope for the treatment of previously incurable diseases, such as genetic disorders, cancers and autoimmune diseases. However, gene therapy requires efficient delivery with cell and tissue specificity, which remains ...
Engineered polysaccharides for controlling innate and adaptive immune responses [0.03%]
用于控制先天性和适应性免疫反应的工程多糖
Jutaek Nam,April Kim,Kidong Kim et al.
Jutaek Nam et al.
Therapeutic interventions can be designed by exploiting the immune system's ability to initiate specific responses to various stimuli. However, specific T cell activation, which is a key target for vaccines and immunotherapies, remains chal...
Lucine L Oganesian,Maryam M Shanechi
Lucine L Oganesian
Neuropsychiatric disorders such as major depression are a leading cause of disability worldwide with standard treatments, including psychotherapy or medication, failing many patients. Deep brain stimulation holds great potential as an alter...
Atharva Sahasrabudhe,Claudia Cea,Polina Anikeeva
Atharva Sahasrabudhe
The brain continuously receives, integrates, and responds to an influx of sensory signals emerging from the internal organs. This is mediated not only through direct neuronal connections defined by the peripheral nervous system, but also en...
Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues [0.03%]
用于细胞和组织光电化学和电化学调制的植入式生物电子设备
Jiuyun Shi,Pengju Li,Saehyun Kim et al.
Jiuyun Shi et al.
Electroceuticals are bioelectronic devices that provide or modulate electrical or electrochemical signals to regulate physiological functions. In particular, devices designed for energy conversion are capable of transforming electrical ener...
Alexandra N Borelli,Kristyn S Masters
Alexandra N Borelli
The extracellular matrix remains under-recognized as a sex-dependent entity. Designing culture environments that account for sex as a biological variable requires considering not only cellular sex, but also the usage of sex-specific scaffol...
Irina Kopyeva,Ryan P Brady,Cole A DeForest
Irina Kopyeva
Light has become an essential tool to make and manipulate living systems in the increasingly intertwined fields of cell biology and materials science. With the ever-expanding interdisciplinary nature of current scientific research and the o...
Sex-specific nanomedicine- and biomaterials-based therapies of chronic wounds [0.03%]
基于纳米医学和生物材料的慢性伤口性别特异性疗法
Negar Mahmoudi,David Nisbet,Irena Pastar et al.
Negar Mahmoudi et al.
Wound healing mechanisms differ depending on the sex, particularly in chronic wounds. Therefore, sex should be considered in the design of nanomedicine- and biomaterials-based wound healing therapies, both in preclinical and clinical testin...
Abhishek P Dhand,Matthew D Davidson,Jason A Burdick
Abhishek P Dhand
Additive manufacturing is an engineering tool that enables the creation of complex structures for biomedical use, such as for 3D scaffolds for tissue engineering and regenerative medicine and in vitro disease models for drug testing. Lithog...