Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD+ biosynthesis and thermogenesis in mice [0.03%]
人血浆源性含eNAMPT的细胞外囊泡可促进小鼠NAD+生物合成和产热
Kiyoshi Yoshioka,Takumi Sugimoto,Mamoru Oyabu et al.
Kiyoshi Yoshioka et al.
Age-associated decline in tissue NAD+ levels contribute to functional impairments, recognized as aging. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme crucial for NAD+ biosynthesis in mammals, is encapsulated in ex...
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo [0.03%]
胶原蛋白氨基酸补充可延缓人类生物衰老并延长寿命
Alexander Dakhovnik,Matilde Mantovani,Marie Knufinke et al.
Alexander Dakhovnik et al.
Collagen supplementation has gained attention with increasing claims regarding its beneficial effects on healthy aging based on clinical observations and lifespan extension in pre-clinical models; however, how and which part of an ingested ...
Prolonged intermittent hypoxia accelerates cardiovascular aging and mortality: insights from a murine model of OSA [0.03%]
长时间间歇性低氧加速心血管衰老并增加死亡率：阻塞性睡眠呼吸暂停小鼠模型的启示
Mohammad Badran,Clementine Puech,David Gozal
Mohammad Badran
Obstructive sleep apnea (OSA) accelerates cardiovascular aging through intermittent hypoxia (IH). We exposed mice to 22 months of IH, modeling lifelong OSA. Compared to controls, IH mice exhibited higher mortality, elevated blood pressure, ...
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline [0.03%]
独居与认知正常人群大脑体积减小及未来可能出现的认知衰退有关联
Mikana Isa,Kenjiro Ono,Moeko Noguchi-Shinohara et al.
Mikana Isa et al.
Social isolation and poor nutrition are recognized risk factors for cognitive decline in older adults. However, the relationship between solitary eating, brain structure, and dietary patterns remains unclear. This study investigated the rel...
Towards global healthy longevity: report from the 1st World Longevity Summit in Kyotango, Japan [0.03%]
迈向全球健康长寿：日本京丹后首届世界长寿峰会报告
Tomoya Kitani,Satoaki Matoba,Yuji Naito et al.
Tomoya Kitani et al.
Aging societies around the world face increasing challenges in promoting healthy longevity. The 1st World Longevity Summit in Kyotango, Japan, convened experts to discuss advances in aging biology, lifestyle medicine, and community-based he...
Age, caste, and social context shape ovarian morphology and transcriptomic profiles in red harvester ants [0.03%]
年龄、种姓和社交环境影响收获蚁卵巢形态及转录组特征
María Fernanda Vergara-Martínez,Dennet Guerra-Sandoval,Berenice Otero-Díaz et al.
María Fernanda Vergara-Martínez et al.
The reproductive division of labor defines eusocial insects like ants, where queens reproduce and workers remain sterile. Yet, some workers retain rudimentary ovaries, raising questions about latent reproductive potential. We examined morph...
Utility of biological aging acceleration in capturing transitions of atrial fibrillation and dementia: a population-based study [0.03%]
基于人群的研究：生物衰老加速在捕捉房颤和痴呆转变中的作用
Yufan Liu,Chenglong Li
Yufan Liu
The biological aging acceleration predicts both morbidity and mortality, while few investigations have examined its utility in evaluating transitions, e.g. development patterns, of atrial fibrillation (AF) and dementia. We aimed to investig...
Global, regional, and national burden of falls among older adults: findings from the Global Burden of Disease Study 2021 and Projections to 2040 [0.03%]
2021年全球疾病负担研究和2040年预测中的老年人跌倒的全球、区域和国家负担
Yang Chen,Feifei Dai,Shulun Huang et al.
Yang Chen et al.
Falls are a significant cause of injury-related morbidity and mortality among older adults worldwide, with a rising incidence in recent decades. Using data from the Global Burden of Disease Study 2021, we analyzed incidence, mortality, and ...
Age-specific tumor-associated macrophage biomarkers underlie metastasis and immune dysregulation in thyroid cancer [0.03%]
年龄特异性的肿瘤相关巨噬细胞生物标志物构成了甲状腺癌转移和免疫失调的基础
Tianyao Chu,Shenglong Xu,Hongyan Chen et al.
Tianyao Chu et al.
Thyroid cancer (THCA) shows rising incidence and aggressiveness in young-onset cases. Through integrated single-cell, transcriptomic, and proteomic analyses, we identified age-specific tumor-associated macrophage (TAM) genes, including OLR1...
The dissipation theory of aging: a quantitative analysis using a cellular aging map [0.03%]
衰老的耗散理论——基于细胞衰老地图的定量分析
Farhan Khodaee,Rohola Zandie,Louis-Alexandre Leger et al.
Farhan Khodaee et al.
We propose a new theory for aging based on dynamical systems and provide a data-driven computational method to quantify the changes at the cellular level. We use ergodic theory to decompose the dynamics of changes during aging and show that...