FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis [0.03%]
FOSL2驱动的子宫内膜基质细胞SASP促进子宫内膜异位症炎症发生
Weiwei Shi,Xinyi Tang,Fei Yang et al.
Weiwei Shi et al.
Endometriosis (EMs) is characterized by chronic pelvic inflammation, but the etiology of this inflammation remains poorly understood. The senescence-associated secretory phenotype (SASP), whereby senescent cells secrete pro-inflammatory cyt...
Early-life sugar rationing, brain aging, and long-term neurodegenerative and psychiatric health outcomes: a population-based natural experiment study [0.03%]
基于人群的自然实验研究发现：生命早期糖食品配给、大脑衰老及长期神经退行性和精神健康结局之间的关系
Xingji Lian,Amei Chen,Xiaoyan Zhu et al.
Xingji Lian et al.
Early-life nutrition is linked to adult brain health, yet evidence from quasi-experimental studies remains scarce. Leveraging the UK's historical sugar rationing as a natural experiment, we examined whether early-life sugar restriction redu...
Geroprotective insights into the natural metabolite spermidine in aging and age-related diseases [0.03%]
天然代谢物亚精胺在衰老及相关疾病中的抗衰老作用机制初探
Zhirui Jiang,Sen Tong,James L Kirkland et al.
Zhirui Jiang et al.
Aging is associated with increased oxidative stress, which leads to pathological vulnerability. Spermidine is a ubiquitous natural polyamine found across all living organisms studied so far and present in multiple food sources. In humans, s...
How epigenetic clocks tick: unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging [0.03%]
表观遗传钟何以“滴答”走时不加龄：解析加速衰老的生物通路和转录组标志物
Thalida Em Arpawong,Steve Cole,Harshanna Badhesha et al.
Thalida Em Arpawong et al.
Epigenetic clocks derived from DNA methylation robustly predict biological aging, health, and mortality, yet differ substantially in their predictive profiles. The biological processes underlying these differences remain poorly understood. ...
Intermittent chloroquine treatment extends lifespan and prevents mammary hyperplasia in female rats while reducing serum ldl and igfbp3 levels [0.03%]
间断使用氯喹可延长雌性大鼠寿命，延缓乳腺增生，并降低血清LDL及IGFBP3水平
Marius Viorel Ionica,Cristin Coman,Anthony William Oliver et al.
Marius Viorel Ionica et al.
In a previous study, chloroquine (CLQ) administration extended lifespan in middle-aged male NMRI mice without systemic toxicity, challenging the view that blockage of autophagy is uniformly detrimental. Here, we evaluated a modified step-do...
Chen Zhou,Yunmeng Bai
Chen Zhou
Sepsis triggers profound organism-wide disturbances, yet the cellular logic underlying its systemic impact remains poorly defined. By integrating single-cell transcriptomes from six septic tissues, we uncovered a conserved cross-tissue prog...
Network-based discovery of regulatory drivers of cognitive decline in alzheimer's disease [0.03%]
基于网络的阿尔茨海默病认知衰退调节驱动因素的发现
Danish Anwer,Arina A,Agata Marchi et al.
Danish Anwer et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder marked by progressive cognitive decline, yet its transcriptional regulatory architecture remains poorly understood. Here, we model sample-specific gene regulatory netwo...
Jinghui Zhong,Deyan Kong,Genpei Luo et al.
Jinghui Zhong et al.
We examined the associations of reproductive behaviors and genetic susceptibility with aging indicators among female participants in the UK Biobank. Reproductive behaviors included the number of children ever born (NEB), age at first birth ...
Biological aging increases risk of postoperative morbidity and mortality: an international, multi-cohort study [0.03%]
生物学老化增加术后发病率和死亡率的风险：一项国际多队列研究
Joseph R Scarpa,M Cary Reid,Olivier Elemento et al.
Joseph R Scarpa et al.
Biological age often diverges from chronological age, yet its independent impact on surgical outcomes remains poorly defined. We evaluated PhenoAge, a validated biological age metric, in an international multi-cohort study comprising over 4...
Telomere integrity, epigenetic aging, and genetic burden shape biological aging trajectories in idiopathic pulmonary fibrosis [0.03%]
端粒完整性、表观遗传衰老和基因负担塑造特发性肺纤维化患者的生物衰老轨迹
Manuela Campisi,Luana Cannella,Filippo Liviero et al.
Manuela Campisi et al.
Idiopathic pulmonary fibrosis (IPF) is a paradigmatic aging-related lung disorder. In this retrospective cohort study, we evaluated 101 treatment-naïve patients at diagnosis (T0) and a subgroup (n = 31) after one year of antifibrotic thera...