Microglial lipid droplets as therapeutic targets in age-related neurodegenerative diseases [0.03%]
小胶质细胞脂滴在年龄相关神经退行性疾病治疗中的作用
Soyoung Sung,Hui-Ju Kim,Sun Joo Cha et al.
Soyoung Sung et al.
Monoclonal antibodies approved for Alzheimer's disease (AD), such as lecanemab and aducanumab, have been shown to enhance microglial phagocytic function, underscoring the therapeutic relevance of microglia in neurodegenerative diseases (NDD...
Cognitive stimulation exerts long-lasting protective effects on the hippocampal vasculature and memory function in a rat model of vascular cognitive impairment [0.03%]
认知刺激对血管性认知障碍大鼠模型海马血管和记忆功能的长期保护作用
Abbie C Chapman,Anduela Thaqi,Risa L Kalish et al.
Abbie C Chapman et al.
Hypertensive individuals with vascular cognitive impairment (VCI) often live alone and are less likely to adhere to prescribed medications, making the development of non-pharmacological interventions critical. How cognitive stimulation affe...
Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database [0.03%]
药物年龄数据库的报告质量、效应大小和偏差的干预措施：方法评价
Austin Parish,John P A Ioannidis,Kevin Zhang et al.
Austin Parish et al.
Though interest has grown significantly over the past decades in interventions that may slow the aging process, most evidence for these interventions still comes from experiments in non-human animals. These studies may suffer from design, q...
Perturbation of multiprotein complexes in skeletal muscle induces protective proteases in the CNS that degrade pathogenic proteins [0.03%]
骨骼肌中多蛋白复合物的扰动诱导中枢神经系统的保护性蛋白酶降解致病蛋白
Mamta Rai,Helen J E Baddeley,Chia-Lung Chuang et al.
Mamta Rai et al.
Many cellular functions rely on multiprotein complexes and their stoichiometric assembly. Reducing the levels of individual complex components can perturb this process and induce corrective stress responses. In addition to local outcomes, c...
Space radiation induces distinct senescent phenotypes: Implications for space travel [0.03%]
太空辐射可诱导不同的衰老表型：对载人航天的启示
Louise E Pitcher,Bipasha Mukherjee,Ashley M Saathoff et al.
Louise E Pitcher et al.
As Earth's magnetic field weakens, space radiation begins to pose a significant threat to the health of not only space travelers, but the world's population. Space radiation, comprising high-energy and high-charge ions, creates distinct clu...
Simple molecules make difference: short peptides play a novel role in slowing senescence [0.03%]
简单分子创造的差异：短肽在延缓衰老中扮演的新角色
Ya Li,Xiangzhan Zhu,Pengya Feng et al.
Ya Li et al.
Aging studies have entered a transformative era with the discovery and application of short peptides as regulators of senescence. These short peptides are encoded by small open reading frames in nuclear, mitochondrial, and viral genomes. Un...
Human fibroblasts from aged individuals exhibit chromosomal instability through replication stress caused by oxidative stress [0.03%]
氧化应激引起的复制应力导致人纤维细胞出现染色体不稳定现象
Kailin Zhu,Guan Chen,Yueyi Ren et al.
Kailin Zhu et al.
Aneuploid cells are known to increase with age. Previously, we demonstrated an increased number of aneuploid fibroblasts isolated from aged mice due to chromosomal instability (CIN), which is caused by oxidative stress. It is unclear whethe...
Stimulation at the frontal cortex influences the exercise activity and skeletal muscle status in senescence-accelerating mice [0.03%]
刺激前额皮质影响衰老加速小鼠的运动活动和骨骼肌状态
Nobuyuki Nagaoka,Akiko Eguchi,Ning Ma et al.
Nobuyuki Nagaoka et al.
Senescence-associated frailty and sarcopenia are global challenges. We here investigated neuronal activity and skeletal muscle biology in senescence-accelerated mouse prone 8 (SAMP8) mice with scalp acupuncture stimulation (SAPS). Excise ac...
Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine [0.03%]
克罗莫林-沉默素1通路调控心、肾和小肠干细胞衰老及细胞增殖功能的机制研究
Dao-Fu Dai,Nastaran Daneshgar,Kaihao Wang et al.
Dao-Fu Dai et al.
We investigate the effects of α-Klotho, an anti-aging hormone, on cell proliferation across three tissues with varying regenerative capacities in the context of aging. Using young and old wild-type mice, alongside old heterozygous Klotho-d...
Depression and social connectedness as mechanisms linking frailty to quality of life in older African migrants in Australia [0.03%]
抑郁症和社交联系在澳大利亚老年非洲移民中连接衰弱与生活质量的中介机制研究
Gideon Dzando,Paul R Ward,Lillian Mwanri et al.
Gideon Dzando et al.
Older Sub-Saharan African (SSA) migrants often face cumulative stressors that heighten vulnerability with age. Frailty acts as a chronic stressor that reduces quality of life, partly through its association with depression, while social net...