Development and validation of a simplified time-dependent interpretable machine learning-based survival model for older adults with multimorbidity [0.03%]
用于多病共存老年人的简化的时序可解释机器学习生存模型的开发和验证
Junmin Zhu,Huanglong Chen,Siyu Duan et al.
Junmin Zhu et al.
Multimorbidity elevates late-life mortality, yet existing tools remain complex. Using two nationally representative Chinese cohorts-the Chinese Longitudinal Healthy Longevity and Happiness Family Study (CLHLS-HF; n = 8675) and the China Hea...
Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila [0.03%]
西里尼：一种新型的抗衰老化合物，可延长秀丽隐杆线虫和果蝇的寿命和健康期
Abdelrahman AlOkda,Shweta Yadav,Alain Pacis et al.
Abdelrahman AlOkda et al.
As aging is the primary risk factor for many chronic diseases, geroscience aims to target aging to delay age-related decline. Here, we identify Cyrene (dihydrolevoglucosenone), a sustainable, biocompatible solvent, as a novel geroprotective...
EAT-Lancet and plant-based diets, plasma metabolomic signatures, and biological aging [0.03%]
基于《柳叶刀· EAT 委员会》的膳食指南和植物性饮食的血浆代谢组谱型与生物学年龄的关系
Jie Li,Jiang Li,Xiaoqin Xu et al.
Jie Li et al.
The EAT-Lancet diet has been recently recommended for its potential health and environmental benefits. Here, leveraging data from the UK Biobank, we performed a comparative analysis to examine the associations of adherence to the EAT-Lancet...
Epigenetic age predictors for non-invasive assessment of human skin [0.03%]
表观遗传年龄预测模型在人类皮肤非侵入性评估中的作用
Angel Menendez Vazquez,Dimitris Katsanos,Miruna Vasile et al.
Angel Menendez Vazquez et al.
Skin is both the most visible and most environmentally exposed organ, with apparent aging phenotypes. DNA methylation clocks faithfully capture the progression of aging, but so far have been limited to training on abundant in vitro material...
Dietary fatty acids and epigenetic aging in US adults: results from the National Health and Nutrition Examination Survey [0.03%]
美国成年人的膳食脂肪酸与表观遗传学衰老：来自全国健康和营养调查的结果
Anne K Bozack,Dennis Khodasevich,Jamaji C Nwanaji-Enwerem et al.
Anne K Bozack et al.
Fatty acids are involved in disease risk and aging processes. In the US National Health and Nutrition Examination Survey (1999-2002), we tested for associations of total, saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), and ...
Efficacy of auditory gamma stimulation for cognitive decline: a systematic review of individual and group differences across cognitively impaired and healthy populations [0.03%]
听觉γ刺激改善认知障碍的系统综述：不同个体和群体的认知损伤与健康人群的差异效应
Eve Bolland,Aoibhe De Burca,Sheng Hsuan Wang et al.
Eve Bolland et al.
Auditory gamma stimulation is a promising non-invasive neuromodulation technique for cognitive decline, with preclinical studies demonstrating therapeutic effects in Alzheimer's disease models. However, translating these findings into human...
27-Hydroxycholesterol triggers microglial senescence subsequent to iron over-loading contributes to brain aging, suppressed by Deferoxamine [0.03%]
27-羟基胆固醇触发铁过载小胶质细胞衰老导致大脑衰老，去铁敏胺可以抑制该过程
Chunyang Yu,Wencheng Wang,Lei Shi et al.
Chunyang Yu et al.
Brain aging is a major factor in cognitive decline and Alzheimer's disease (AD) progression. Aging-induced microglial senescence critically drives inflammaging and brain aging processes. Nevertheless, the underlying reasons and mechanisms t...
Peripheral B cell alteration in patients with premature ovarian insufficiency [0.03%]
卵巢早衰患者外周B细胞改变分析
Yueshuang Lu,Hanbing Zhu,Changjing Wang et al.
Yueshuang Lu et al.
Premature ovarian insufficiency (POI) is one of the most common diseases contributing to declining fertility globally. Autoimmune dysregulation has been implicated in POI, but the role of B cell and its subsets in immune dysregulation in PO...
The neural correlates of cognitive training-induced gains in aging: a meta-analysis of neuroimaging studies [0.03%]
基于神经影像学研究的老化认知训练增益的神经相关性meta分析
Geng Li,Yang Liu,Chengzhen Liu et al.
Geng Li et al.
Cognitive training is a promising non-pharmacological approach to mitigate age-related cognitive decline, yet the underlying neural mechanisms remain unclear. We conducted a meta-analysis of 24 neuroimaging studies comparing cognitive train...
Frailty and transitions across cardiometabolic disease states: evidence from multistate models in a 16-year Chinese cohort [0.03%]
脆弱性与心血管代谢疾病状态变化：来自中国16年随访队列多状态模型的证据
Rui Hang Zhang,Jiao Wang,Ying Wang et al.
Rui Hang Zhang et al.
Frailty is a prevalent geriatric syndrome, but its role in cardiometabolic disease (CMD) progression remains unclear. We examined whether frailty predicted CMD transitions. We included 22,754 participants aged 50+ from the Guangzhou Biobank...