Recommendations for biomarker data collection in clinical trials by longevity biotechnology companies [0.03%]
长寿生物技术公司在临床试验中收集生物标志数据的建议
Chiara M S Herzog,Jesse R Poganik,Nicola Boekstein et al.
Chiara M S Herzog et al.
Biomarkers of aging have the potential to transform geroscience clinical trials because of their broad applications in stratifying participants, prioritizing interventions, and monitoring responses to geroprotectors. As longevity biotechnol...
Dmitrii Kriukov,Evgeniy Efimov,Mikhail S Gelfand et al.
Dmitrii Kriukov et al.
Aging clocks use machine learning to estimate biological age as a proxy for general health state. Here, we critically examine their practical value, highlighting fundamental challenges: abstract definitions, inconsistent clinical validation...
Age-related nigral downregulation of the Parkinson's risk factor FAM49B primes human microglia for inflammaging [0.03%]
帕金森病风险因子FAM49B的年龄相关性下调使人类小胶质细胞易发生因衰老引起炎症反应
Jacqueline Martin,Guan-Ju Lai,Christopher Y Park et al.
Jacqueline Martin et al.
Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), which is associated with changes in microglia function. While age remains the biggest risk factor, the underlying mo...
Sociodemographic differences in discontinuation of high-risk medications: a retrospective cohort study [0.03%]
高风险药物停药的社会人口学差异回顾队列研究
Katharina Tabea Jungo,Niteesh K Choudhry,Julie C Lauffenburger
Katharina Tabea Jungo
Older adults frequently use medications deemed high-risk, despite clinical recommendations supporting their discontinuation. We conducted a retrospective cohort study using administrative claims data from a large national U.S. health insure...
Mikhail I Krivonosov,Tatiana A Khabarova,Elena V Kondakova et al.
Mikhail I Krivonosov et al.
Biological clocks aim to estimate the physiological state of an organism, or of specific organs or systems, from the perspective of aging. The inferred individual age acceleration is presumably linked to increased mortality and morbidity ri...
Biological aging, left ventricular dysfunction and mortality in patients with heart failure with preserved ejection fraction [0.03%]
生物衰老、左心室功能不全与保留射血分数的心力衰竭患者的死亡率关系
Xinghao Xu,Zihao Huang,Xingfeng Xu et al.
Xinghao Xu et al.
Accelerated biological aging (BA) is linked to adverse cardiovascular events, but its role in heart failure with preserved ejection fraction (HFpEF) remains unclear. We analyzed 1,727 HFpEF patients from RED-CARPET Study (ChiCTR2000039901),...
AI-aided identification of dual-purpose therapeutic targets PRPF19 and MAPK9 in hepatocellular carcinoma and cellular senescence [0.03%]
人工智能辅助鉴定肝细胞癌和细胞衰老的双重功能治疗靶点PRPF19和MAPK9
Christopher Ren,Geoffrey Ho Duen Leung,Qiuqiong Tang et al.
Christopher Ren et al.
Hepatocellular carcinoma (HCC) is one of the most prevalent and malignant forms of primary liver cancer, with limited therapeutic options and a poor prognosis. Cellular senescence contributes to the progression of chronic liver disease whil...
Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease [0.03%]
细胞衰老中的线粒体功能障碍：通向神经退行性疾病的桥梁
Adam J Hruby,Ryo Higuchi-Sanabria
Adam J Hruby
Senescent cells, characterized by a state of irreversible proliferative arrest and inflammatory profile, have emerged as drivers of age-related decline. Growing evidence suggests that alterations in mitochondrial function and morphology pla...
Joseph P Errico,Benneth Ben-Azu,Makenna Gargus et al.
Joseph P Errico et al.
The central nervous system, comprised of the brain, spinal cord, and nerves, includes the autonomic nervous system (ANS) that regulates involuntary functions. Within the ANS, the sympathetic and the parasympathetic nervous systems (SNS and ...
Milos Havelka,Atsushi Satomura,Hiroki Yamaguchi et al.
Milos Havelka et al.
We aimed to develop and validate a urinary miRNA aging clock, positioning urine as a scalable, non-invasive aging-biomarker source. Using machine learning on 6331 adults, our clock achieved MAE ≈ 4.4 years (R² ≈ 0.79) in independent vali...